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A simple osmometer
Remove the bottom from a small glass bottle about 2.5 cm in diameter. Fit a one-hole stopper tightly into the bottom and put a 50 cm length of glass tubing or a length of two soda straws by the hole.
Place a piece of cellophane or parchment paper over the other end of the bottle and fasten it securely by winding with various turns of string or strong thread. Fill the bottle with a very concentrated sugar solution and change the one-hole stopper being sure that no air bubbles remain inside the bottle. Clamp the osmometer in a glass of water and permit to stand a few hours.
Two parents who are each known to be carriers of an autosomal recessive allele have four children. None of the children has the recessive condition. What is the probability that
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