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Numerous receptors have intrinsic or tightly related enzyme activity. On the required of ligand to their extracellular face like receptors undergo a conformational change and activate an enzyme activity. In case of the insulin receptor that is a complex of two α- and two β-subunits held together through disulfide bonds the polypeptide hormone insulin the ligand binds to the extracellular face of the α-subunits. The receptor then undergoes a conformational modify leading to the autophosphorylation of the cytosolic domain of the β-subunit. By the specifically hydroxyl groups in the side chains of certain tyrosine residues are phosphorylated with ATP being the phosphate donor. Phosphorylated receptor is then identify by other proteins in the cytosol which in turn modulate various intracellular events permitting the cell to respond to the hormone appropriately. Additionally, β-subunit can straight phosphorylate other goal proteins within the cell.
figure: Signal transduction through an enzyme-linked receptor such as the insulin receptor.
Helobial Type - Endosperm This type of endosperm is intermediate between the nuclear and the cellular types. The division of the primary endosperm nucleus is followed by the f
FLUORIDE It is mostly available in drinking water. Fluoride is essential for the formation of enamel of the teeth. Deficiency of fluoride causes weakness of enamel.
What has caused evolution? 1) Different individuals have dissimilar characteristics 2) These differences result in altering abilities to reproduce under local circumstances
Importance of Dark Period For quite sometime the role of light period (photoperiod) was emphasised in flowering? However, based on certain experiments it was realised that it
Define the working of Cyclomixer? This is an electrical mixer used for mixing the contents of a test tube. The speed of the mixer can be adjusted to your requirement. This is a
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Post removal Technique -Roto-pro bur - Roto-pro bur is a taper bur having are six-sided, non-cutting flutes used a high-speed hand-piece around the circumference of the post t
In sulfur photosynthetic bacteria what is the molecule that donates hydrogen for photosynthesis? In sulfur photosynthetic bacteria the substance that donates hydrogen is hydrog
Briefly explain about the Sit-ups Test? To measure muscular endurance, bent knee sit-ups can be done. Sit-ups begin with the subject lying flat on their backs with their knees
Q. What are the cells produced in the first stage of the embryonic development called? The cells that result from the cleavage (the first stage of the embryonic development) ar
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