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The Expectation/Conditional Maximization Either algorithm which is the generalization of ECM algorithm attained by replacing some of the CM-steps of ECM which maximize the constrained expected complete-data log-likelihood, with steps that maximize correspondingly constrained real likelihood. The algorithm can have substantially faster convergence rate than either the EM algorithm or ECM measured using either the number of iterations or actual computer time. There are two reasons for this enhancement. First, in some of the ECME's maximization steps the actual likelihood is being conditionally maximized, rather than the current approximation to it as with EM and ECM. Second,
ECME permits faster converging numerical techniques to be used on only those constrained maximizations where they are most efficacious.
Compliance : The extent to which the participants in a clinical trial follow trial protocol, for instance, following both the intervention regimen and trial procedures (clinical vi
we are testing : Ho: µ=40 versus Ha: µ>40 (a= 0.01) Suppose that the test statistic is z0=2.75 based on a sample size of n=25. Assume that data are normal with mean mu and standa
Markers of disease progression : Quantities which form a general monotonic series throughout the course of the disease and assist with its modelling. In uasual such quantities are
A term commonly encountered in the analysis of the contingency tables. Such type of frequencies are the estimates of the values to be expected under hypothesis of interest. In a tw
cholscores Treatment income ($000) Patient ID low Income? 0.6 Old 21.3 2 Yes 0.17 Old 27.2 13 Yes 0.69 New 27.1 16 Yes 1.09 Old 94.8
The Null Hypothesis - H0: β0 = 0, H0: β 1 = 0, H0: β 2 = 0, Β i = 0 The Alternative Hypothesis - H1: β0 ≠ 0, H0: β 1 ≠ 0, H0: β 2 ≠ 0, Β i ≠ 0 i =0, 1, 2, 3
Information theory: This is the branch of applied probability theory applicable to various communication and signal processing problems in the field of engineering and biology. In
Persson Rootze ´n estimator is an estimator for the parameters in the normal distribution when the sample is truncated so that all the observations under some fixed value C are re
Probit analysis is the technique most commonly employed in the bioassay, specifically toxicological experiments where the group of animals is subjected to known levels of a toxin
Cauchy distribution : The probability distribution, f (x), can be given as follows where α is the position of the parameter (median) and the beta β a scale parameter. Moments
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