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This is extension of the EM algorithm which typically converges more slowly than EM in terms of the iterations but can be much faster in the whole computer time. The general idea of the algorithm is to replace M-step of each EM iteration with the sequence of S >1conditional or constrained maximization or the CM-steps, each of which maximizes the expected complete-data log-likelihood found in the previous E-step subject to constraints on parameter of interest, θ, where the collection of all the constraints is such that the maximization is over the full parameter space of θ. Because the CM maximizations are over the smaller dimensional spaces, many times they are simpler, faster and more reliable than corresponding full maximization known in the M-step of the EM algorithm.
Back-projection: A term most often applied to the procedure for reconstructing plausible HIV incidence curves from the AIDS incidence data. The method or technique assumes that th
Interval-censored observations are the observations which often occur in the context of studies of time elapsed to the particular event when subjects are not monitored regularl
Data which occur when failure period is recorded which are dependent. Such type of data can arise in number contexts, for instance, in epidemiological cohort studies in which th
It is the survey which is carried out in Great Britain on a continuous basis since 1971. About 100 000 households are included in this sample every year. The main goal of the surve
a. Explain the meaning of the word non-orthogonal. b. What condition(s) must exist for non-orthogonality to occur? Be specific.
Hurdle Model: The model for count data which postulates two processes, one generating the zeros in the data and one generating positive values. The binomial model decides the bina
In the experimental studies, the collection of individuals to which the experimental process of interest is not applied. In the observational studies, most often used for a collect
Protocol is the formal document outlining the proposed process for carrying out the clinical trial. The basic features of the document are to study the objectives, patient selecti
Cohort study : An investigation in which the group of individuals (or the cohort) is identi?ed and followed prospectively, possibly for many years, and their subsequent medical his
Multilevel models are the regression models for the multilevel or clustered data where units i are nested in the clusters j, for example a cross-sectional study where students are
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