Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Dose-response extrapolation
In order to be compared to human exposure levels, the animal data need to be extrapolated to doses much lower than those studied. This extrapolation procedure is uncertain both qualitatively and quantitatively. The nature of the hazard may change with dose or may disappear entirely. The selected dose-response model may be incorrect if the nature of the response in animals and humans is qualitatively the same. Not only is the equivalent dose estimate in animals and humans a problem in comparative pharmacokinetics, but also is the change in metabolism with dose. The metabolism of chemicals at high and low doses may differ. For example, high doses often overwhelm normal detoxification/metabolism pathways and produce adverse effects that would not occur at lower levels. High doses can induce higher rates of enzyme production, physiological changes and dose-related pathological changes. The toxicologist must consider the potential impact of these and other possible dose-related changes on the extrapolation of the adverse effect to lower doses.
Explain Positive Staining Technique? Here, a stain has a positively charged chromophore that gets attached to the negatively charged outer surface of the microbial cell and thu
Q. Which are the beings that constitute the kingdom Monera? The kingdom Monera is the kingdom of the prokaryotes, archaebacteria and composed of bacteria. Q. Which are the
What are the positions of actin and myosin molecules in the sarcomere before and during the muscle contraction? Schematically actin filaments attached perpendicularly to both s
what are the significance of zoological parks in conversation
CHARACTERISTICS OF FEMALE'S SKELETON - 1. Skull is lighter. 2. Shoulders are nanow. 3. Sacrum is shorter but wider. 4. Pelvis is wider. 5.
Glucometer mainly for the following purpose. (i) In acute and chronic care facilities at the patient's bedside, in clinics or hospitals. (ii) In physician's clinics. (iii
Yellow Fever Yellow fever vaccine, a single-dose attenuated live virus vaccine prepared in eggs, should be given at least 10 days before travel to endemic areas, which include
#FUCTIONS OF THE EPIDERMIS#
Q. What is the vena cava? Which type of blood circulates within the vena cava? The vena cava is either of two large veins that debouch into the right atrium the superior vena c
Determine SNP variation among the aligned DNAs for a genomic region. See below for how to count SNP variation. The output file (Your_name_snp.txt) should have two
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd