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An approach to investigations designed to recognize a particular medical condition in the large population, usually by means of a blood test, which might result in the considerable saving in the number of tests carried out. In its place of testing each person separately, blood samples from, k people are pooled and analysed jointly. If the test is negative, this test clears k people. If the test is positive in nature then each of the k individual blood samples should be tested separately, and in all k 1 tests are needed for these k people. If the probability of the positive test (p) is less, the scheme is likely to give the outcome in far fewer tests being essential. For instance, if p 0:01, it can be shown that the value of k minimizes the expected number of tests per person is 11, and that expected number of the tests is 0.2, resulting in 80%saving in the number of tests compared with the testing each and every individual separately.
Prevalence : The measure of the number of people in a population who have a certain disease at a given point in time. It c an be measured by two methods, as point prevalence and p
Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic
MAREG is the software package for the analysis of the marginal regression models. The package permits the application of generalized estimating equations and the maximum likelihoo
cholscores Treatment income ($000) Patient ID low Income? 0.6 Old 21.3 2 Yes 0.17 Old 27.2 13 Yes 0.69 New 27.1 16 Yes 1.09 Old 94.8
Perturbation theory : The theory useful in assessing how well a specific algorithm or the statistical model performs when the observations suffer less random changes. In very commo
K-means cluster analysis is the method of cluster analysis in which from an initial partition of observations into K clusters, each observation in turn is analysed and reassigned,
Higher criticism is a multiple-comparison test concept arising from the situation where there are number of independent tests of significance and interest lies in the rejecting jo
Outlier is an observation which seems to deviate markedly from the other members of the sample in which it happens. In the set of systolic blood pressures, {125, 128, 130, 131, 19
The Current status data arise in the survival analysis if the observations are limited to the indicators of whether or not the event of interest has happened at the time the sample
Chain-binomial models : Models arising in mathematical theory of the quite infectious diseases, which postulate that at any stage in the epidemic there are a certain number of the
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