Do enzymes act better under acid or basic pH?

Most enzymes act in pH among 6 and 8, a range that corresponds to the general acidic level of cells and blood. There are enzymes, though, that act only under very acid or very basic pH. So enzyme activity depends on pH interval.

In the stomach, for instance, the gastric juice has a very low pH, around 2, and there the enzyme pepsin acts to intensively digest proteins. In the duodenum, pancreatic secretions enhance the pH of the enteric juice for the action of other digestive enzymes, for example, trypsin.