Discuss the role of nadph in erythrocytes, Biology

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Discuss the role of NADPH in erythrocytes

The fragility of erythrocytes  is impaired in the absence of NADPH generation due to the deficiency of glucose-6-phosphate dehydrogenase  thereby causing  hemolytic anaemia when the red blood cells are subjected  to certain drugs such as  primaquine and sulphonamide.  An inverse correlation has been found between the activity of glucose-6-phosphate dehydrogenase and the fragility of  red cells  (i.e. susceptibility to hemolysis).

 


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