Explain the Difficulty of establishing and sustaining collaborations?

Working with another is both rewarding and challenging. Working across disciplines is even more so. Though, there is a need to overcome language/terminology barriers and to understand the scientific method from the perspective of another discipline, and there are few role models to follow. Collaboration needs effort, and even if this attempt is applied by researchers committed to a common problem, collaboration is often a slow process. At last, a critical mass of people interested in the same problem is frequently required to solve complex, quantitative problems in biology, and it needs continued attempts to sustain collaboration.