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Determine the Symptoms of Shigellosis
Symptoms: Pathogenicity involves the release of lipopolysaccharide endotoxin, which infects the intestinal mucosa. Shigellosis ranges from fairly mild to very severe and fatal. The onset is usually abrupt, requiring from 1-7 days of incubation, but sometimes requiring as many as 14 days. Symptoms are abdominal pain and cramps caused by inflammation of mucus surface of large intestine, nausea, diarrhoea, vomiting and elevated temperature. The mortality associated with S. dysenteriae infection is around 20% but it is much lower with other species. In severe instances, excessive diarrhoea leads to electrolytic imbalance in the bloodstream and ulceration in large intestine. There may be kidney failure, jaundice and persistent internal bleeding. The infection is localized and organs other than the large intestine are not invaded.
Myocardial contractility is mostly dependent on the level of sympathetic nerve activity and is also increased by circulating catecholamines and inotropic drugs like dopamine and do
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identify structural modifiactions of the stomach and small intestine walls that enhance the digestive processes in these regions
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