Determine the closed-loop negative feedback system, Biology

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Which of the following is a situation in which a closed-loop negative feedback system is converted to an open-loop system? A disease that destroys all the

A. V2 Receptors in all the epithelial cells of the kidney.

B. AQP2 channels in all the epithelial cells of the kidney.

C. G-proteins in all the epithelial cells of the kidney.

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