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Which of the following defines why the vast majority of segregation errors in human patients include the two sex chromosomes (XXY, XO, XYY) or chromosome 21 (triple 21)?
A. The centromeres of these three chromosomes lack attachment sites for spindle microtubules therefore leading to a higher than normal segregation error rate.
B. These three chromosomes have the highest probability to be mis-segregated while anaphase I and II of meiosis.
C. Cells are more likely to survive with abnormal numbers of these three chromosomes whereas segregation errors of the other 20 human chromosomes are totally lethal.
D. Chromosome 21 as well as both sex chromosomes lack sequences that are categorized by proteins of the spindle assembly checkpoint (SAC). Thus the cell proceeds to anaphase even if these three chromosomes have failed to reach the metaphase plate.
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How old is the universe? From the analysis of data collected by the Hubble telescope the age of the universe is estimated to be about 12 billion years.
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