Describe the regulation of pyruvate dehydrogenase, Biology

Assignment Help:

Describe the regulation of pyruvate dehydrogenase through covalent modification.

PDH exists in 2 forms :  Inactive, phosphorylated and Active, dephosphorylated. The active form of PDH is phosphorylated by a protein kinase with the help of ATP and Mg++ to  the inactive  form of PDH. Acetyl CoA  and NADH are activators for this action and CoA, NAD+,  and pyruvate are inhibitors. The inactive  form of PDH is dephosphorylated by phosphoprotein phosphatase to the active form in the presence of increased Ca++  ion concentration.

 


Related Discussions:- Describe the regulation of pyruvate dehydrogenase

Diagnosis and treatment of rheumatic fever, Diagnosis  History and ...

Diagnosis  History and Physical examination.   John's criteria.   Echocardiogram show valvular insufficiency.   Chest X-ray cardiomegaly if CHF present.   EC

Advances in neurodiagnostic techniques, Advances in neurodiagnostic techniq...

Advances in neurodiagnostic techniques Major scientific and technology advances have made it easier to correlate behaviours suspected as having a neurological basis with actual

Explain significant proportion of starch in the normal diet, Significant pr...

Significant proportion of starch in the normal diet A significant proportion of starch in the normal diet escapes degradation in the stomach and small intestine and is labeled

What is benedict's test and its principle, What is Benedict's Test and its ...

What is Benedict's Test and its Principle? This test is answered by all reducing sugars with a free aldehyde or ketone groups. Monosaccharides possess a free aldehyde or ketone

Fats , FATS ( = True Fats, Triglycerides, Neutral Fats) They are es...

FATS ( = True Fats, Triglycerides, Neutral Fats) They are esters of fatty acids and 3-carbon trihydric alcohol glycerol (= glycerine). T rue fat is also called trig

Define effect of nutrition on the immune system, Define Effect of Nutrition...

Define Effect of Nutrition on the Immune System? Nutrition has a strong influence on the immune system of the elderly. Ageing induces dysregulation of the immune system, mainly

What is megalobastic anemia, Question 1) What is megalobastic anemia? Disc...

Question 1) What is megalobastic anemia? Discuss briefly its lab diagnosis. How would you differentiate megaloblastic anemia from other anemias? Question 2) What is hem

How do you define normal pulmonary vasculature, Q. How do you define Normal...

Q. How do you define Normal Pulmonary Vasculature? Pulmonary vessels are seen in the medial 2/3 of the lung. Vessels are generally not identified in the lateral third. The rad

What do you mean by sex ratio, What do you mean by sex ratio? Sex Rati...

What do you mean by sex ratio? Sex Ratio is defined as "the number of females per 1000 males". Sex ratio is an important social indicator to measure the extent of prevailing e

Homo erectus, Homo erectus first arose about 1.6 million years ago and is b...

Homo erectus first arose about 1.6 million years ago and is believed to have lived for atleast 600,000 years at a time when the transition to Homo sapiens took place. The fosSil fi

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd