Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Shoot multiplication -clonal propagation, Shoot Multiplication -Clonal Prop...

Shoot Multiplication -Clonal Propagation This is the most important step with respect to the rate of propagation and genetic uniformity of the product. The most reliable and

Briefly explain about phase of the plasmodium life cycle, Q. To which phase...

Q. To which phase of the plasmodium life cycle do the typical chills and fever of malaria correspond? The typical fever and chills episodes of malaria correspond to the phase w

Where letters represent genetic markers and black dot, Two homologous human...

Two homologous human chromosomes have the following structure: where the letters represent genetic markers and the black dot represents the centromere. 1. Diagram the two chromosom

Describe the applications of vitamin B1, Describe the Applications of vitam...

Describe the Applications of vitamin b1 The steadily increasing consumption of white flours  (insufficiently ground and thus low in vitamin content) by large sections of the po

Explain trapezoidal full mucoperiosteal flaps, Explain Trapezoidal Full Muc...

Explain Trapezoidal Full Mucoperiosteal Flaps a) Similar to rectangular flap except: The 2 vertical incisions are at obtuse angle with the Horizontal incision, b) Mostly

Define beaker - nutritional biochemistry, Define Beaker - Nutritional Bioch...

Define Beaker - Nutritional Biochemistry? It is used for storing a liquid to be used in a reaction and for dissolving a substance in a solvent to make its solution. A beaker sh

Explain about osseointegration, Explain about Osseointegration Osseoint...

Explain about Osseointegration Osseointegration is regarded as the process of direct bone apposition on implant surfaces where the bone in contact with the implant later underg

Show the directly visible chemical characters, Q. Show the Directly Visible...

Q. Show the Directly Visible Chemical Characters? Very few chemical substances in plants can be observed directly, but the few substances such, starch grains which are pres

Properties of pyridoxine, Properties of pyridoxine a)  It forms white, ...

Properties of pyridoxine a)  It forms white, odourless  crystals. b)  The compound is readily soluble  in water. c)  When  a neutral or alkaline solution of pyridoxine is

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd