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Q. Describe the Basic Mechanisms in Plaque Formation?
In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.
Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.
Define observation or inference for picric acid test? 1. A mahogany red colour will be seen. The mahogany red colour indicates the presence of reducing sugar. All monosaccharid
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Fungal Infections Intravenous infusion of amphotericin B deoxycholate frequently causes fever and chills, and sometimes headache, nausea, vomiting, hypotension and tachypnea,
What is polymorphism
PLACEN T A - Placenta is the intimate connection between the foehls and the uterine wall of the mother to exchange the materials. Placenta is a tempormy endocrine gland
What is the system that permits movement and fixation to echinoderms? The system that allows movement and fixation to substrates in echinoderms is known as the ambulacral syste
All tissues have some capability for synthesis of the non-essential amino acid remodeling, amino acids and conversion of non-amino acid carbon skeletons into amino acids and other
What are the affinities of pteridophytes with gymnosperms?
Define Regents for Determination of Inorganic Phosphorus? 1. Trichloroacetic acid (10%) - Dissolve 100 g of high grade crystalline acid in distilled water and dilute to 1 Litre
Q. Pathophysiology of Cardiac tamponade? Progressive increase in pericardial fluid results in progressive increase in intrapericardial pressure, till a critical volume is reach
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