Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Define nutritional requirements for extreme environments, Define Nutritiona...

Define Nutritional Requirements for Extreme Environments? Human beings have been able to survive and work under extreme environments of almost all regions of the earth, from po

Regulation of ovarian activity, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Explain pound cake test - preformance evaluation, Pound cake test In so...

Pound cake test In some cases, oil or margarine creaming volume is most accuratelymeasured by preparing a regular pound cake, omitting the chemical leavener andmeasuring the vo

TISSUES, difference between axon and cyton

difference between axon and cyton

Zoology, give the discriptive account of nerilla which belongs to class a...

give the discriptive account of nerilla which belongs to class arciannelida in phylum annelida

Explain how a human eye is working for the body, Explain how a human eye is...

Explain how a human eye is working for the body. Every tissue in the body requires basic components which are either derived from the body itself or we acquire them from extern

Define the etiology for bulimia nervosa, Define the Etiology for Bulimia Ne...

Define the Etiology for Bulimia Nervosa? Bulimia nervosa is a multifaceted disorder with psycologic, physiologic, developmental and cultural components. There may be a genetic

Define about the chemotherapy, Define about the Chemotherapy - Cancer? ...

Define about the Chemotherapy - Cancer? Chemotherapy results in lot of side effects. This is because the drug effects are not specific to cancer cells alone. Even the host cell

Phylum, morphological characterstics of e histolytica

morphological characterstics of e histolytica

Explain catastrophism, Catastrophism Once-popular belief which events in t...

Catastrophism Once-popular belief which events in the history of earth had occurred in the past a sudden events and by processes different from those operating today. The periods

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd