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Q. Describe the Basic Mechanisms in Plaque Formation?
In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.
Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.
Presenting Features Anterior abdominal wall and anterior bladder wall is deficient and on the surface everted posterior wall of bladder with two ureteric orifices is seen.
The article entitled "Life on Earth" is trying to make the point that RNA likely included before DNA. Forthis article which of the following is false? A. Chains of RNA nucleoti
Determine the term - Test-retest reliabilities The test manual reports reliability data. Test-retest reliabilities for the 13 main scales range from .78 to .96. The problem of
TETRASACCHARIDES The oligosaccharides are formed by condensation of four monosaccharides. T rachyos e is a nonreducing tetrasaccharide found in plants as transport ca
DIFFERENCE S BETWEEN "A" AND "I" BANDS A-Ban d (Anisotropic band) I-Ban d (Isotropic band) 1. It
WHAT is zoonosis?
Pediculosis and scabies Phthirus pubis (pubic lice), which can be found on eyelashes, back, axillary and leg hairs as well as pubic areas, and Sarcoptes scabiei infestation (s
Surplus red blood cells, required to meet an emergency, are generally stored in what organ of the human body? Is it the: a) Liver b) Spleen c) pancreas d) Kidneys
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Q. Describe the phylogenetic system of classification? 1) Hutchinson believed in Monophyletic origin of Angiosperms from a hypothetical group, which he' named, as Proangiosperm
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