Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Define drug effects on lipid metabolism, Define Drug effects on Lipid Metab...

Define Drug effects on Lipid Metabolism? Drugs can affect the metabolism of various essential nutrients in the body. These impairments are highlighted herewith: Lipid metabo

Determine the functional food in europe, Determine the Functional Food in E...

Determine the Functional Food in Europe? Functional foods are: Conventional/everyday foods consumed as a part of the normal diet; Composed of naturally-occurring co

Phototheraphy and exchange transfusion, PHOTOTHERAPHY AND EXCHANGE TRANSFUS...

PHOTOTHERAPHY AND EXCHANGE TRANSFUSION: This section will enable you to acquire skills related to phototherapy and exchange transfusion. You will also review the indication

Replication of chromatin, Whenever a chromosome is replicated the replicati...

Whenever a chromosome is replicated the replication machinery passes by the nucleosomes without deleting the histones from the DNA. How this happens is since not fully understood.

Define precaution for estimation of vitamin c in lemon juice, Define precau...

Define precaution for estimation of vitamin c in lemon juice? 1. Rinse all glassware with 3% metaphosphoric acid before you begin your practical and subsequently each time you

Explain the communication process, Q. Explain the communication process? ...

Q. Explain the communication process? Communication is a process by which information is exchanged between individuals through a common system of symbols, signs, or behavior. C

Define some symptoms of epilepsy, Define some Symptoms of Epilepsy? The...

Define some Symptoms of Epilepsy? The general symptoms of epilepsy include weakness, fainting, uncoordinated muscle movement. Based on the drug, common side effects include nau

Define the magnesium requirements in body, Define the Magnesium Requirement...

Define the Magnesium Requirements in body? Let us learn about the magnesium requirements. Since plant foods are particularly high in magnesium, on a vegetarian diet with plenty

Determine food sources of ascorbic acid (vitamin c), Determine Food Sources...

Determine Food Sources of ascorbic acid (vitamin c)? Food sources of vitamin C include: Rich sources: Amla and guava. Good sources: Drumstick leaves, other leafy ve

Microbiology, 2. Vaccinations against various childhood diseases have contr...

2. Vaccinations against various childhood diseases have contributed to the entry of women, particularly mothers, into the fulltime workplace. a. Is this statement supported by data

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd