Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Define reflection - endodontic surgery, Define Reflection - Endodontic Surg...

Define Reflection - Endodontic Surgery -  Marginal gingival is very delicate and easily injured, therefore you should begin reflection of the vertical incision in the attached

Which of substance are microfilaments, Q. Which Of substance are microfilam...

Q. Which Of substance are microfilaments made and what are the properties of these elements that give motility to cells? Microfilaments are made of actin a protein. The contrac

Name the alloys which are commonly used, Name the alloys which are commonly...

Name the alloys which are commonly used The most commonly used alloys are Ti-6Al-4V and Ti-6Al-4V extra low interstitial (ELI). Commercially pure Titanium comes in different gr

Define amino acid requirements for human, Define Amino acid requirements fo...

Define Amino acid requirements for Human? Data regarding the essential amino acid requirements of infants, children and adults are given in terms of egg protein and cow's milk

What is the logic of the transfusional compatibility, What is the logic of ...

What is the logic of the transfusional compatibility concerning the ABO blood group system? The transfusional compatibility for the ABO system takes into account the antigens s

How is the body of gastropods divided, How is the body of gastropods divide...

How is the body of gastropods divided? The body of gastropods is separated into three main portions: a) Head, b) The visceral mass and c) Foot.

What is the average number of minutes a cell, You have 200 cells and find 1...

You have 200 cells and find 120 in interphase, 57 in prophase, 8 in prometaphase, and 5 in metaphase, 8 in anaphase and 2 in telophase. (None in G0 phase). it takes 18 hours to com

In what order should personal protection be removed, Q. In what order shoul...

Q. In what order should Personal Protection be removed? Personal protection is removed in following order: Gloves Mask Glasses Wash hands

Determine st-segment elevation, Q. Determine ST-Segment Elevation? Ans...

Q. Determine ST-Segment Elevation? Ans. Exercise induced ST-segment elevation is common in subjects with post MI stress tests in leads where Q-waves are present. It has be

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd