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Q. Describe the Basic Mechanisms in Plaque Formation?
In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.
Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.
Micro Debrider: long , it's tip as hand spreader, not smooth and resemble H file. - These instruments have a hedstrom cutting configuration with a standard 0.02 taper and
Photosynthetically Active Radiation This is usually in direct proportion with the incident solar radiation, you know that tropic$ are probably the best illuminated part of the
describe the effects of the failure of the pancreas to produce sufficient insulin
What is the main moral problem about the cloning of human individuals? As well biological perils, a very serious moral problem involves the nucleus transplantation technology c
Action potentials include changes in the membrane potential of an axon, as shown in the schematic below. During the refractory period, sodium channels are inactivated and
venn diagram
Q. Explain about Metabolic diseases? Metabolic diseases, as you already know, refer to those disorders in which the various reactions in the cells are effected (production of e
Water Relations in Terrestrial Environment Insects are the largest group of metazoans which have most successfully invaded the terrestrial environment. In addition, most arach
Q. What is constitutional unit of proteins? The constitutional units of proteins are the amino acids.
How does the plant cell wall react when it is placed under hypotonic medium? Ans) The plant cell wall (the covering of the cell outside to the cell membrane) is made of cellulos
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