Describe the basic mechanisms in plaque formation, Biology

Assignment Help:

Q. Describe the Basic Mechanisms in Plaque Formation?

In experimental models and human disease, the first morphologic phenomenon observed in plaque formation is adhesion of monocytes to an intact endothelial surface. This adhesion is followed by monocyte migration into the intima. In the intima, monocytes are activated, converted to macrophages, and may divide. Lipid uptake by macrophages then leads to the formation of the foam cell. Many factors act in concert to cause monocyte migration to allow the incoming monocytes to establish themselves in the intima. The endothelial surface is intact in the initial phase of coronary atherosclerosis. There is no exposure of the subendothelial connective tissue matrix and therefore no adhesion of platelets to the vessel wall. Much of the cholesterol and esters in a lipid core is released from the cytoplasm of dying foam cells. Active plaques contain numerous macrophages clustered at the edge of the core with the expression of a range of metalloproteinases that likely are engaged in the active destruction of the collagen matrix.

Smooth muscle cell migration and proliferation as well as collagen deposition are driven by growth factors produced by virtually every cell type, including smooth muscle cells themselves. The normal media is a vascular, but once intimal thickening occurs, new vessels grow in from the adventitia and reach the base of the plaque.


Related Discussions:- Describe the basic mechanisms in plaque formation

Compute how much of the absorbance of the bsa, For a sample containing both...

For a sample containing both protein and nucleic acid, the absorbance measured at a particular wavelength will be the sum of contributions from both types of molecule. Using the pr

Explain principle of fehling''s soxhlet method, Explain Principle of Fehlin...

Explain Principle of Fehling's Soxhlet method (Lane-Eynon method)? Reducing sugars are those which have free sugar groups and hence may be estimated directly by titrating the s

Factors affects oxygen dissociation curve -organic phosphate, Factors affec...

Factors affects Oxygen Dissociation Curve -Organic Phosphate The presence of organic phosphates in the red blood cells helps to explain many peculiarities of the oxygen dissoc

Marchantia , why vegetative reproduction use in marchantia

why vegetative reproduction use in marchantia

Purpose of supervision - management principles, Purpose of Supervision: ...

Purpose of Supervision: Purpose: To help the personnel to grow, to know themselves and what they need in order to render the most efficient service and to give them assistance

What is population growth rate, Q. What is population growth rate? The ...

Q. What is population growth rate? The Population growth rate (PGR) is the percent variation between the numbers of individuals in a population at two different times. Thus the

PROTOZOA, WHAT IS THE CLASSIFICATION OF PROTOZOA ..

WHAT IS THE CLASSIFICATION OF PROTOZOA ..

What is insect killing jar, Insect killing jar Secure a wide-mouth glas...

Insect killing jar Secure a wide-mouth glass jar with a screw top or single which closes very tightly. Place a wad of cotton in the bottom and cover it with a round piece of ca

Excretion in animal, Excretio n I n  Animal To give out nitrogenous...

Excretio n I n  Animal To give out nitrogenous waste products after oxidation of food is excretion. EXCRE T O R Y MATERIALS - 1 .      AMMONIA - Animals are

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd