Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Synthesis of sucrose, Many of the glyceraldehyde 3-phosphate produced by th...

Many of the glyceraldehyde 3-phosphate produced by the Calvin cycle in chloroplasts is exported to the cytosol and used to produce the disaccharide, sucrose. 1 st the   glyceralde

Syngamy - protozoan, Syngamy - Protozoan The two gametes may be morpho...

Syngamy - Protozoan The two gametes may be morphologically similar (isogametes) or dissimilar (anisogametes). The gametes also vary in form, they may be flagellated or amoeboi

Cells, describe the cell theory and its exception

describe the cell theory and its exception

Introduction to fertilization, INTRODUCTIO N - Fertilization is a c...

INTRODUCTIO N - Fertilization is a complex process which involves fusion of male & female gametes. The male gamete in animals is called as sperm & the female gamete as o

Counselling process of diabetic patient, Let us first learn about learn the...

Let us first learn about learn the points counsellor has to keep in mind for positive outcome of the counselling. The counsellor achieves the positive outcome of counselling, couns

What is cyanotic spells, What is Cyanotic Spells ? Hypercyanotic or Cy...

What is Cyanotic Spells ? Hypercyanotic or Cyanotic spell is a pediatric emergency, which requires prompt recognition, and intervention to prevent disabling cerebro-vascular i

What is the life cycle of the hookworms, What is the life cycle of the hook...

What is the life cycle of the hookworms? Adult hookworms within the human intestine release eggs that are eliminated with the human feces. Under adequate conditions of moisture

Illustrate the maturation of honey, Q. Illustrate the maturation of honey? ...

Q. Illustrate the maturation of honey? Honey is the oldest sweet food known to man. Although honey is a natural sweetener, it is considered a refined sugar because 96% of dr

What is probing depth, What is Probing depth Probing depths can be infl...

What is Probing depth Probing depths can be influenced by the tissue type- shallow depths are associated with a keratinized collar, whereas deeper depths are associated with mo

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd