Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Categorisation of major brain functions, Categorisation of Major Brain Func...

Categorisation of Major Brain Functions As a framework, the major brain functions typically divided into modalities and domains. The major modalities are motor function and th

Evolution and scope of dental implantology, The need to replace missing tee...

The need to replace missing teeth has haunted humans for time immemorial. Since antiquity man has attempted to solve the problems associated with failing dentition. The goal of mod

Rna molecule have two polynucleotide chains like the dna, Q Does RNA molecu...

Q Does RNA molecule have two polynucleotide chains like the DNA? Only DNA has two polynucleotide chains. The RNA is formed by just one polynucleotide chain.

Water soluble vitamins - b complex vitamins and vitamin c, Define Water sol...

Define Water soluble Vitamins - B complex Vitamins and Vitamin C? Vitamins are essential nutrients found in foods. The requirements are small but they perform specific and vit

Cnidarians: obelia, why is obelia considered to be of special interest in Z...

why is obelia considered to be of special interest in Zoology as an animal showing an intermediate grade of organisation

Genetically modified foods-tomatoes, Normal 0 false false f...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Genetics, What is pedigree analysis . How to solve the complicated question...

What is pedigree analysis . How to solve the complicated questions of pedigree . How to identify wheather it is dominant or reccessive its genotype

Differance between rescue-capacity-building strategy, QUESTIONS: Write ...

QUESTIONS: Write an analysis of the Chapter Twelve, the concluding chapter in ROLL AWAY THE STONE. It will be worth UP TO 50 points if you do it well. Submit it through the "Ex

Zoology, About phylum platy helmenthus

About phylum platy helmenthus

Explain the classification of hydrocolloids by function, Classification of ...

Classification of hydrocolloids by function It must be clear to you now that gum ghatti, gum karaya, gum tragacanth ( classified as exudate gums) locust bean  gum, guar g

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd