Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

What similarities do birds and reptiles share, What similarities do birds a...

What similarities do birds and reptiles share regarding external coverage, reproduction and excretion? Regarding external coverage, birds are same to reptiles as they present

Records and reports - nursing service administration, RECORDS AND REPORTS: ...

RECORDS AND REPORTS: The principles of administration are described as  'POSDCORB'.  The  'R' stands for recording and reporting. Recording and reporting is related to all oth

Recovery of by-products: coal, Recovery of tar: the coke oven gas coming o...

Recovery of tar: the coke oven gas coming out from ovens is passed through a tower where liquid ammonia is sprayed. The tar and dust are removed and then recovered. Recover of

Different from all the other cellular microbes, How are the bacteria and th...

How are the bacteria and the archaea different from all the other cellular microbes? -They have cell walls? -They can move? -They reproduce asexually? -They have no nucleus?

What are examples of the ecological and economic, What are examples of the ...

What are examples of the ecological and economic importance of molluscs? Molluscs are significant players in several food chains in ecosystems. Many marine molluscs are part of

Explain post-lyme disease syndrome, Explain Post-lyme disease syndrome  ...

Explain Post-lyme disease syndrome  Some treated patients whose objective manifestations of Lyme disease have resolved with antibiotic treatment report subjective symptoms suc

Why do organisms live in certain places, Why do organisms live in certain p...

Why do organisms live in certain places? Think of that, the temperature dissimilarity in the desert is huge. So in order to survive, the cactus plant decreases heat gain and he

Explain rectangular full mucoperiosteal flaps, Explain Rectangular Full Muc...

Explain Rectangular Full Mucoperiosteal Flaps - Endodontic Surgery      a. Releasing and relaxing "vertical" incisions, with the Horizontal incision, b. Causes re

Diagnostic procedures for acute glomerulonephritis, Diagnostic Procedures ...

Diagnostic Procedures     Taking Clinical history    Urine analysis    Blood sample  for  estimation  of blood urea nitrogen    Antistrepto lysine  (ASO) titer

Diffrence between fish epidermis and amphibian epidermis, Q. How different ...

Q. How different is the fish epidermis from the amphibian epidermis? The fish epidermis is very contains and thin mucus-secreting cells the fish skin doesn't present keratin, t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd