Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Cardiomyocytes and motor neurons, Describe the mechanisms and genetic regul...

Describe the mechanisms and genetic regulations that underpin how two cells such as cardiomyocyte and a motor neuron have identical gnomes, yet are functionally and structurally di

Explain the use of enzyme assay, Explain the use of Enzyme assay Enzym...

Explain the use of Enzyme assay Enzyme assay is also used for research into such processes as the browning of plant products which poses problems during value addition. The br

What would the volume for reaction, The component is DNA. The stock concent...

The component is DNA. The stock concentration is 10mg/ml and the final concentration/amount is 25ug. What is the volume for 1 reaction? For 5 reactions?

Discuss the following term in brief - adaptive radiation, Discuss the follo...

Discuss the following term in brief - Adaptive  radiation Evolution of a variety of different species from a single common ancestor. Each is adapted for a particular niche, and

Interdependance, Give an example of how two organisms are interdependent.

Give an example of how two organisms are interdependent.

Valve replacement, Valve Replacement Replacement of the diseased valve...

Valve Replacement Replacement of the diseased valve is done. This is done biologic tissue valves or mechanical valves. Three types of biologic tissue valves are used. Aut

Our healthi diet, in what form is most carbohydrates is taken in normal die...

in what form is most carbohydrates is taken in normal diet

How all the exercises are active exercises, How All these exercises are act...

How All these exercises are active exercises All these exercises are active exercises that is active exercises are those type of physical activities carried out by the individ

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd