Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Why is it necessary to maintain the ph level, Q Coming from the acid pH of ...

Q Coming from the acid pH of the stomach which pH level does the chyme find when it enters the duodenum? Why is it necessary to maintain that pH level in the small intestine? What

Explain the cultural practices of single crop, Explain the Cultural Practic...

Explain the Cultural Practices of single crop Continuous cultivation of a single crop over years on the same site causes accumulation of a particular group of microbes, which d

Why the peritoneal cavity differ from the normal state, How does the presen...

How does the presence of thick, cloudy, yellowish fluid in the peritoneal cavity differ from the normal state?

Explain biochemical tests bacterial testing, Explain Biochemical Tests Bact...

Explain Biochemical Tests Bacterial Testing? It deals with the various biochemical tests used to differentiate microorganisms. Identification of an unknown organism isolated fr

What is the molecular formula of the compound, A solid compound was found t...

A solid compound was found to contain 42.11% C, 51.46%O and 6.43% H by weight. The molecular weight of the compound was 341. What is the molecular formula of the compound?

Marking regulations of honey, Q. Marking regulations of honey? The mar...

Q. Marking regulations of honey? The marking regulations indicate that each container of honey shall be suitably marked so as to give suitable information as follows: a) N

Why is blood significant for larger animals, What is the alternative means ...

What is the alternative means for transport of substances in animals without a circulatory system? Why is blood significant for larger animals? In animals that do not present t

Differences between budding and fission, Differences between Budding and Fi...

Differences between Budding and Fission Both budding and fission are identical in at least one way in that the young ones produced by these procedures are the result of direct

A dihybrid cross yields 320 f2 offspring, A dihybrid cross yields 320 F2 of...

A dihybrid cross yields 320 F2 offspring. How many are expected to resemble the homozygous recessive parental?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd