Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Define proteins required for underweight - nutritional care, Define Protein...

Define Proteins required for underweight - Nutritional Care? Proteins are required for tissue building, as well as, to take care of the daily wear and tear. Under weight indivi

Inter specific incompatibility, Inter specific Incompatibility This t...

Inter specific Incompatibility This type of incompatibility is characterized by the prevention of fusion of gametes between members of different species. The incompatibility

What are the dietary principles, The dietary principles underlying the ente...

The dietary principles underlying the enteric diet  include: High calorie High protein High carbohydrate Moderate fat High  fluid Low fibre and soft diet

What is osteoblast, What is osteoblast The osteoblast is the key for th...

What is osteoblast The osteoblast is the key for the development of new bone. It is essential that a large number of osteoblasts accumulate on the implant surface(contact osteo

Explain the principle or theory of biuret method, Explain the Principle or ...

Explain the Principle or Theory of biuret method? If a strongly alkaline solution of Biuret is heated with very dilute copper sulphate, a violet colour is obtained. The substan

Harmons, which was the first harmone discovered#

which was the first harmone discovered#

Structural differences between roots and shoots, What are the structural di...

What are the structural differences between roots and shoots? What structures are unique to each?

What are some examples of interspecific competition, Q. What are some examp...

Q. What are some examples of interspecific competition? Instance of interspecific competition are the dispute among worms, vultures, flies and microorganisms for carrion and th

Explain what is probing depth, Q. Explain What is Probing Depth? This p...

Q. Explain What is Probing Depth? This parameter is applicable to one stage implants when they are evaluated prior to prosthetic phase and used to evaluate the health of the im

What is isotope switching, It is conversion of antibody class to another re...

It is conversion of antibody class to another resulting from genetic rearrangement of heavy chain same region genes in B cells. Isotope switching is also known as class switching.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd