Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Spoilage of fish, Q. Spoilage of Fish and other Sea Foods Fish and other...

Q. Spoilage of Fish and other Sea Foods Fish and other marine foods are second only to meat and poultry as a staple animal food around the world. India is one of the important f

Vibriosis/campylobacteriosis, Vibriosis/campylobacteriosis This is gen...

Vibriosis/campylobacteriosis This is genital disease of cattle and sheep. The causal organism Campylobacter fetus is a gram negative, curved or spiral shaped bacteria having s

#title.examples of classes of vertebrates, how to explain an example from e...

how to explain an example from each class of vertebrate

Acclimation and acclimatisation, Normal 0 false false false...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

In which lysosomic enzymes play a fundamental role, Q. What are the various...

Q. What are the various biological examples in which lysosomic enzymes play a fundamental role? The remodelation of the osseous tissue, the function of the elimination of the t

What is the results of congenital pulmonary stenosis, What is the Results o...

What is the Results of Congenital Pulmonary Stenosis? Early mortality for open pulmonary valvotomy in neonates varies between 6 and 10 per cent. For infants and children, surgi

Physiological & socio psychological factor- public nutrition, Define Physio...

Define Physiological and Socio Psychological Factors - public nutrition? Food related behaviour depends on a combination of biochemical factors, mainly, physiological aspects a

How chloroplasts multiply, Q. How chloroplasts multiply? Like mitochond...

Q. How chloroplasts multiply? Like mitochondria chloroplasts have their own the DNA, ribosomes and RNA and they self-replicate through binary division.

Excretion, living organisms and their excretory products

living organisms and their excretory products

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd