Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Explain the preliminary treatment of implant therapy, Preliminary treatment...

Preliminary treatment of implant therapy It is important to ensure a healthy oral environment before going ahead with implant procedure. The treatment needs to be initiated in

Explain the analysis of food samples, Explain the Analysis of Food Samples?...

Explain the Analysis of Food Samples? Now, in this practical, we shall deal with the endogenous and exogeneous microorganisms which are present on the food as contaminants. We

Types of stem cells-pulp tissue revascularization, Embryonic stem cells: c...

Embryonic stem cells: can differentiate into all cell types of the specialized embryonic tissues when given sufficient and necessary stimulation for a specific cell type, e.g. Plu

Define nutrition counseling - management of eating disorders, Define Nutrit...

Define Nutrition Counseling - Management of Eating Disorders? Nutrition counseling can be used to accomplish a variety of goals, such as reducing behaviours related to the eati

State the term - localisation scales, State the term - localisation scales ...

State the term - localisation scales The localisation scales are also empirically derived, being based on studies of patients with localised brain lesions. There are frontal,

What is the role of vitamin k in the blood coagulation, Q. What is the orga...

Q. What is the organ where most of the clotting factors are produced? What is the role of vitamin K in the blood coagulation? Most of the clotting factors are produced in the l

How water balance take place in human body, How Water Balance Take Place in...

How Water Balance Take Place in Human Body? The amount of fluid in the body is tightly controlled because imbalance can be devastating. In a normal individual, the maintenance

Evolution, write similaritie between the two species?

write similaritie between the two species?

Electron transport , 1) It is the series of coupled oxidation/reduction rea...

1) It is the series of coupled oxidation/reduction reactions where the electrons are passed like hot potatoes from one membrane-bound protein/enzyme to another before being finally

What is the typical vegetation of the grasslands, What is the typical veget...

What is the typical vegetation of the grasslands? The Grasslands are mainly formed of herbaceous (nonwoody) vegetation: grass, small trees and bushes.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd