Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Explain about extra low interstitial, Explain about Extra low Interstitial ...

Explain about Extra low Interstitial Extra low Interstitial (ELI) contains low levels of oxygen dissolved in interstitial sites in the metal. Lower amounts of oxygen and iron i

Define reagents required and methodology for mucic acid test, Define Reagen...

Define Reagents Required and Methodology for Mucic Acid Test? -   Sugar solution -   Conc. Nitric acid Methodology Take about 50 mg of sugar in a test tube. Add 1 ml

Can we use ethylene oxide as chemical sterilant, Q. Can we use Ethylene oxi...

Q. Can we use Ethylene oxide as chemical sterilant? Ethylene oxide: This is considered as the only chemical sterilant while the others are considered merely as disinfectan

Explain the postoperative nutritional care, Explain the Postoperative Nutri...

Explain the Postoperative Nutritional Care? The therapeutic goal for the post-operative patient is rapid recovery to normal function and well being, minimum complications and e

Left internal mammary artery and coronary artery, Left internal mammar...

Left internal mammary artery (LIMA): It is most often used for bypassing left anterior descending (LAD) coronary artery and its diagonal branch. The right internal mammary

How does the odor of flower petals help pollination, How does the odor of f...

How does the odor of flower petals help pollination? The purpose of the perfume is to attract a pollinator - insect, bat, bird or whatever. The reward for the pollinator is a m

How is the blood typing concerning the abo system, How is the blood typing ...

How is the blood typing concerning the ABO system and the Rh usually done? In the blood typing for the ABO system and the Rh system a blood sample is collected from the person

Explain about the micronutrient deficiencies, Explain about the Micronutrie...

Explain about the Micronutrient Deficiencies? Micronutrient deficiencies are more common during calamities. Can you guess, why? This is due to the lack of diversified food item

Explain food habits - diet presciption, Food Habits Food Habits: These ...

Food Habits Food Habits: These must be known  so that the diets  can  be  recommended keeping in mind the  food preferences  of  the patient. Whether a person is  a vegetarian

Criteria to complete evolutionary branch of vertebrates, What are the six c...

What are the six criteria used to build a complete evolutionary branch of vertebrates? Dichotomy in each of the six following criteria builds the vertebrate evolutionary branch

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd