Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

What factor below contributed to the current variations, According to the t...

According to the theory of natural selection, what factor below contributed to the current variations in beak sizes of finch species on the Galapagos islands? a. Finches dispersed

What do you mean by pericardial effusion, Q. What do you mean by Pericardia...

Q. What do you mean by Pericardial effusion? Collection of fluid in the pericardial sac is known as Pericardial effusion. All cases of pericarditis can lead to pericardial effu

What is transportation of sick newborn infants-heart disease, What is Trans...

What is Transportation of Sick Newborn Infants with Heart Disease Communication : The decision to transport a newborn to a tertiay referral centre with facilities for specia

Determine about the diseases sleep attacks, Determine about the diseases Sl...

Determine about the diseases Sleep attacks These are brief, often irresistible, episodes of sleep, probably slow wave, NREM, naplike sleep that last about 15 minutes and can oc

How would you perform abo blood grouping, Question 1 How would you perform...

Question 1 How would you perform ABO blood grouping? Add a note on advantages and disadvantages of each method. Also discuss the precautions you may take to avoid errors in variou

Explain benefits of protein, Explain benefits of Protein Protein: Once ...

Explain benefits of Protein Protein: Once the energy requirements have  been estimated, protein requirements can be addressed. The aim is to achieve nitrogen balance. There are

Eye - conjuctiva, CONJUNCTI V A - Ectodermal in origin. Formed by epi...

CONJUNCTI V A - Ectodermal in origin. Formed by epidermis. It is thin, transparent covers cornea. Made up of stratified epithelium. It has 2 parts - (i) Ocular conjunct

Give choice of catheters for ventriculography, Q. Give Choice of Catheters ...

Q. Give Choice of Catheters for Ventriculography? 1) Pigtail Catheter: This catheter developed by Judkins has end hole and side holes. The end hole permits insertion of the c

Why cerebellum more developed in mammals that fly or jump, Q. Why is the ce...

Q. Why is the cerebellum more developed in mammals that fly or jump? The cerebellum is the main brain structure that coordinates the movement and the equilibrium of the body. F

Photosynthesis, discovery of two light phase in photosynthesis

discovery of two light phase in photosynthesis

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd