Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Connecting implants to natural teeth, Connecting implants to natural teeth ...

Connecting implants to natural teeth and use as pier abutments The issue of connecting implants and teeth to support a fixed prosthesis is controversial and unresolved. The inh

The nurse''s role in relieving the child''s stress, The Nurse's Role  in ...

The Nurse's Role  in Relieving  the Child's Stres s Turning passive experiences into active ones that facilitate the child's healthy - Problems-I  adjustment to hospitalization

Is the embryonic development in birds indirect or direct, Q. Is the embryon...

Q. Is the embryonic development in birds indirect or direct? The embryonic development is direct there is no larval stage. Q. What are the predominating chemical compounds

Explain techniques for broken instrument removal, Explain Techniques for Br...

Explain Techniques for Broken Instrument Removal Described by Gary Carr Staging platform (cutting in flat surface) a) Create straight line access to separated file using mod

Procedure - separation of amino acid by paper chromatography, Explain Proce...

Explain Procedure for Separation of Amino Acids by Paper Chromatography? Now carry out the procedure following the steps given herewith: 1. Take a circular Whatman No 1 filt

Littoral and benthic zone, Littoral and Benthic Zone Littoral Zone ...

Littoral and Benthic Zone Littoral Zone This is the shallow water zone, near the shore, where light penetrates to the bottom. Rooted plants can grow only in this region.

Discuss the importance of septa in maxillary sinus, Discuss the importance ...

Discuss the importance of septa in maxillary sinus during a sinus lift or graft surgery. Septa, when present in the maxillary sinus will divide it into sections creating separa

Describe what are non degradable pollutants, Question : (a) Briefly de...

Question : (a) Briefly describe what are non degradable pollutants? (b) What do you meant by ichthyosarcotoxic fishes and give two examples of ichthyosarcotoxic fish poiso

Explain the process of repositioning - endodontic surgery, Explain the Proc...

Explain the Process of Repositioning - Endodontic Surgery 1. Reposition the flap gently, 2. Approximate incision lines closely as possible 3. Pressure application "surgic

What is the transcription of the gene downstream, A substitution mutation o...

A substitution mutation occurs in the GRE making it unrecongnizable to the glucocorticoid receptor. What impact would this have on the transcription of the gene downstream of this

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd