Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Describe genetic recombination , Describe Genetic Recombination ? Genet...

Describe Genetic Recombination ? Genetic recombination, which provides the variation necessary for evolution, can occur through a variety of processes during cell reproduction:

Define the metabolism and respiration of cornea, Define the metabolism and ...

Define the metabolism and respiration of cornea. Metabolism and Respiration of Cornea The cornea requires energy for the maintenance of its transparency. Energy in

Explain multidrug resistance, Multidrug Resistance  Treatment of MDRTB ...

Multidrug Resistance  Treatment of MDRTB is  based on limited data; patients should be referred, if possible, to clinicians who have experience in treating such cases. MDRTB (r

Problems with untreated/ammoniated crop residues, Problems with untreated/a...

Problems with untreated/ammoniated crop residues Besides the low energy and protein contents, crop residues generally contain low content of minerals such as Calcium, Phosphor

Explain spread plate method - pure culture techniques?, Explain Spread Plat...

Explain Spread Plate Method - Pure Culture Techniques? In this method, diluted microbial suspension containing about 30 to 300 colonies is spread uniformly on the agar surface

Why the av node of a mammalian heart is destroyed, The AV node of a mammali...

The AV node of a mammalian heart is destroyed. A. A depolarization in a cell in the left atrium will cause a depolarization of a cell in the left ventricle. B. The contracti

Vitamins and minerals requirement in diabetes, Q. Vitamins and minerals req...

Q. Vitamins and minerals requirement in diabetes? The recommendation of vitamins and minerals is the same as for general population. However, lower levels of magnesium are ass

Are there differences between the male and female skeletons, Q. Are there d...

Q. Are there differences between the male and female skeletons? Many general differences exist between female and male skeletons. Male skeleton is normally larger and heavier t

Jaber, What is genetic drift?

What is genetic drift?

What is the difference between lungs and gills, Q. What is the difference b...

Q. What is the difference between lungs and gills? Lungs and Gills are richly vascularized organs that serve for gas exchange between the environment and the circulatory system

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd