Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Explain about the ph - nutritional biochemistry, Explain about the PH - Nut...

Explain about the PH - Nutritional Biochemistry? You have already studied about pH in your undergraduate years and know what it means. Yes, mathematically we can define pH as e

What does an anther have on it, What does an anther have on it? The ant...

What does an anther have on it? The anther is the part of the flower that keeps the pollen. This and the filament both make up the stamen.

Explain marine oils, Marine oils These oils typically contain large amo...

Marine oils These oils typically contain large amounts of long - chain omega-3-polyunsaturated fatty acids, with up to six double bonds and they are usually rich in vitamins A

Population parameters and regulation, Population Parameters and Regulation ...

Population Parameters and Regulation Population can be defined as a group of organisms of same species occupying a specific area at a particular time, such as all the deer or

What is the meaning of term - plasticity, What is the meaning of term - Pla...

What is the meaning of term - Plasticity The notion of brain plasticity has been of interest to researchers and clinicians alike for decades. The outcome of injury is the resul

Define the future challenges of spatial processes, Define the Future challe...

Define the Future challenges of spatial processes? Understanding the dynamics of stochastic spatial systems, systems with a multitude of spatial scales, and systems along with

Explain the basal metabolic rate, Explain the Basal Metabolic Rate? The...

Explain the Basal Metabolic Rate? The Basal Metabolic Rate (BMR) gradually decreases after the attainment of maturity due to a decrease in muscle mass tissues and physical acti

Male reproductive disorders-congenital impotentia genarandi, Congenital imp...

Congenital impotentia genarandi Some bulls which are otherwise normal and healthy produce semen containing spermatozoa with specific morphological abnormalities together with

Explain barrier techniques - personal protective equipment, Q. Explain Barr...

Q. Explain Barrier Techniques - Personal Protective Equipment? The use of personal protective equipment (PPE) - clothing, masks, eyewear, and gloves - is part of routine dental

If the protein binds to any other proteins, You are studying a gene, and it...

You are studying a gene, and its effects on skin cells. You want to find out A) If the protein made encoded by this gene binds to DNA in a particular place B) if the protein binds

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd