Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Define criteria for assessment of pyridoxine status, Define Criteria for As...

Define Criteria for Assessment of Pyridoxine Status? Vitamin B 6 status is most appropriately evaluated by using a combination of indicators,  namely plasma PLP concentration,

Explain the phylum molluska - mollusks, Explain the Phylum Molluska - Mollu...

Explain the Phylum Molluska - Mollusks? You are probably very familiar with members of this phylum. The mollusks include the octopuses, squids, cuttlefish, scallops, oysters, c

Regents for estimation of vitamin c - colorimetric method, Define Regents f...

Define Regents for Estimation of Vitamin C - Colorimetric Method? 1. 2, 4 dinitrophenylhydrazine reagent - Dissolve 2 g of dinitrophenyl hydrazine in 100 ml of 9N sulphuric aci

Preparation of patient for fasting blood sugar analysis, Preparation of Pat...

Preparation of Patient for Fasting Blood Sugar Analysis 1. Blood for fasting blood sugar (plasma glucose) analysis should be drawn after the individual has fasted overnight (8-

Explain indifferences in ionic composition, Indifferences in ionic composit...

Indifferences in ionic composition Answer A. across membranes can be created through the action of ATP driven pumps as long as number of negative and positive ions on remain equal

Define surgery, Define Surgery? Surgery ! Does the word itself not crea...

Define Surgery? Surgery ! Does the word itself not create a feeling of anxiety and bring our thoughts towards a debilitating state of health which would be accompanied by pain,

Photosynthesis, test to prove that carbondioxide is needed for photosynthes...

test to prove that carbondioxide is needed for photosynthesis to take place

Define mechanism for provide protection against colon cancer, Define Mechan...

Define Mechanisms for Provide protection against colon cancer? Several plausable mechanisms have been formulated by which fibre may provide protection against colon cancer. The

Energy requirements to get ideal body weight, Q. Energy requirements to get...

Q. Energy requirements to get ideal body weight? Calories: The energy requirements of adult patients is governed by their present body weight and the need to maintain a desira

Describe the complex spatial patterns of biodiversity, Q. Describe the comp...

Q. Describe the complex spatial patterns of biodiversity? To describe the complex spatial patterns of biodiversity, ecologists and biogeographers have found it useful to expres

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd