Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Wet stigma - category of stigma, Wet Stigma - Category of Stigma Petun...

Wet Stigma - Category of Stigma Petunia shows several randomly distributed 2-celled papillae on its surface. In a developing stigma, the epidermis is covered by a continuous,

Sedentary or light activity lifestyles - physical activity, How Sedentary o...

How Sedentary or light activity lifestyles affects Physical Activity? These people have occupations that do not demand much physical effort, we not required to walk long distan

Classification, what is binomial nomenclature? What are the importance of i...

what is binomial nomenclature? What are the importance of it?

How much nacl can be made using 30g of nacl, How much of a 10% w/v of nacl ...

How much of a 10% w/v of nacl can be made using 30g of nacl? Please show all steps.

Why enzymes work to speed up a chemical reaction, Enzymes work to speed up ...

Enzymes work to speed up a chemical reaction by: a. attaching coenzymes to the substrate b. heating up the substrate c. lowering the activation energy of the reaction d. supplyi

Explain the concept of atoms are associated, What is the logical order in w...

What is the logical order in which the concepts of atoms, molecules, cells... up to biosphere are associated? Atoms form molecules that structure cells that form tissues that f

Explain puewabilitation programme in details, Explain puewabilitation progr...

Explain puewabilitation programme in details ? Education, counselling, and behavioural interventions are important elements of cardiac rehabilitation. In this guideline, "educ

What is protocooperation, Q. What is protocooperation? The Protocoopera...

Q. What is protocooperation? The Protocooperation is the ecological interaction in which both participants benefit but which is not obligatory for their survival. The Protocoop

What is bigunnides, Q. What is Bigunnides? Bigunnides: They are atni d...

Q. What is Bigunnides? Bigunnides: They are atni diabetic drugs which do not affect the output of insulin. These are preferred to sulphony lureas because they do not cause we

Osmoregulation in terrestrial environment, Osmoregulation in Terrestrial En...

Osmoregulation in Terrestrial Environment  Earlier you have learnt about osmoregulation in aquatic environment. In this section, we shall study how the terrestrial animals cop

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd