Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Explain the effect of deficiency of vitamin e, Explain the Effect of Defici...

Explain the Effect of Deficiency of Vitamin E? Fortunately, vitamin E deficiency in human is extremely rare. This may probably be due to its wide occurrence. in natural foods a

Respiration, abnormal lung volumes and capacities

abnormal lung volumes and capacities

Urea, notes on urea

notes on urea

Theory of embryology - theory of pangenesis, THEO R Y OF PANGENESIS - ...

THEO R Y OF PANGENESIS - Proposed by Charles Darwin. According this miniature present in the every body cell i.e. called gemmule

Diversity, WHAT IS PANDA BAO BAOLOGY.?

WHAT IS PANDA BAO BAOLOGY.?

What is hypertrichosis of the ear, In humans, attached earlobes are a domin...

In humans, attached earlobes are a dominant feature over free earlobes while hypertrichosis of the ear is a holandric (Y-linked) feature. A person with attached earlobes and extens

List the goals of management of type 1 diabetes mellitus, Q. List the goals...

Q. List the goals of management of Type 1 Diabetes Mellitus? Goals of management of Type 1 Diabetes Mellitus: a) to keep blood sugar level as close to normal as possible.

Measurement and evaluation of food texture, Q. Measurement and Evaluation o...

Q. Measurement and Evaluation of Food Texture? Kinesthetic characteristics deal with the sense of feel, just like the characteristics of appearance deal with the sense of sight

Define causes of iron deficiency anaemia, Define Causes of iron Deficiency ...

Define Causes of iron Deficiency Anaemia? Anaemia is a condition in which the blood cannot carry enough oxygen. This may be because there are fewer red blood cells than normal,

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd