Describe lipoprotein, Biology

Assignment Help:

Q. Describe Lipoprotein?

Ans.

There is considerable current interest in this lipoprotein, which consists of LDL with an additional apoprotein-apoprotein (a) attached to it via a disulphide bond. Apoprotein (a) has striking structural homology with plasminogen, a zymogen of the coagulation and fibrinolytic system.

Lipoprotein (a) concentrations vary widely within and between populations. In Europeans most individuals have low levels but there is a pronounced positive skew to the distribution with very high levels in some people. The variation appears to be largely determined by the apoprotein (a) gene locus. Plasma concentrations correlate inversely with the molecular mass of apoprotein (a), which exists in many different size polymorphisms.

The physiology of lipoprotein (a) remains poorly understood but its rate of production appears to be a major determinant of its plasma concentration. It is likely that apoprotein (a) is directly secreted by the liver and then associates with LDL.

The importance of lipoprotein (a) relates to its association with CHD risk and, form its structural homology with plasminogen. It is tempting to speculate that this lipoprotein may be an important link with the coagulation system. Many case control studies have demonstrated that high lipoprotein (a) concentrations relate to CHD risk but the association appears to be influenced by the prevailing LDL concentration - the higher the LDL, the stronger the relationship between lipoprotein (a) and CHD.


Related Discussions:- Describe lipoprotein

Explain the potassium conductance, In a neuron at rest, the membrane A....

In a neuron at rest, the membrane A. voltage will be less than zero. B. sodium conductance is greater than the membrane potassium conductance. C. voltage is less than the

Spinal cord sectioned at the cervical level, Q. How is it explained that a ...

Q. How is it explained that a person with the spinal cord sectioned at the cervical level is still able to perform the patellar reflex? The arch reflex depends only on the inte

What is ciguatera fish poisoning, Question : (i) What is Ciguatera Fis...

Question : (i) What is Ciguatera Fish Poisoning provide some examples of fishes implicated in Ciguatera Fish Poisoning in Mauritius? (ii) Provide a general account of its d

Ketosis, K e to s i s It is also known as acetonemia in bovines or...

K e to s i s It is also known as acetonemia in bovines or pregnancy toxaemia in sheep and is associated with ketonemia, ketonuria and low blood glucose. E t iol

Name the phases into which hiv infection is often divided, What are the thr...

What are the three phases into which the HIV infection is often divided? The HIV infection is often separated into three phases: the acute phase, from the infection to 1 until

Embryo-sac, Embryo-sac : Embryo-sac is formed from megaspore mother cel...

Embryo-sac : Embryo-sac is formed from megaspore mother cell. In embro-sac, there are 7 cells arranged in 3 groups. The 7 cells are one egg (female gamete), 2 synergids,

Pisces, weberian oscles found in

weberian oscles found in

Horse diseases-equine infectious anaemia, Equine infectious anaemia Eq...

Equine infectious anaemia Equine infectious anemia (EIA), an acute or chronic viral disease of the equines, shows intermittent fever, loss of weight, depression, progressive w

Silver point extended below canal orifice-endodontics, Silver point extende...

Silver point extended below canal orifice: - This discrepancy between the round silver wire and an irregularly shaped canal provides the clinician with an opportunity to use so

Xerarch - kinds of succession, Xerarch - Kinds of Succession When the ...

Xerarch - Kinds of Succession When the succession takes place in drier area, i.e., the succession progresses from xeric to mesic conditions. It is further subdivided as:

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd