Describe lifetime risk estimation, Biology

Assignment Help:

Describe Lifetime Risk Estimation ?

Traditional statistical and epidemiological methods of estimating long-term risks do not accurately reflect population burden of disease. The long-term risk estimation is also problematic because they do not account for competing ride that become increasingly relevant over longer term follow-up. Methods of estimating lifetime risk overcome those difficulties and can provide more accurate risk prediction. Lifetime risk estimation is useful for assessing population burden of a disease, predicting the future burden of the disease and directly comparing absolute lifetime risks between the diseases.

A number of studies have used lifetime risk calculation to examine influence of risk [actors on the lifetime risk of CAD and CVD. Even taking a single risk factor like total cholesterol level, a Framingham study was able to show disparity between the short-team and lifetime results for CAD. Men at age 50 with total cholesterol 2401ngldl or higher had a 10 year risk of 15 per cent whereas the lifetime risk was 63 per cent. For women the corresponding figure was 8 per cent and 53 per cent. Using the ATP-111 online risk calculator, a 45 year old obese, lion-smoking nondiabeticanali with total cholesterol of 200mg/d1, HDL cholesterol of 40 mg/dl and untreated systolic BP of 135 mmHg has an estimated hard coronary risk of only 3 per cent. However his predicted lifetime risk for CVD is 50 per cent and predicted median survival is about I0 years shorter than an man of the same age with optimal risk factors. For a women with same level of risk factors at age 45, the estimated 10-years coronary risk is less than 1 per cent, compared with a lifetime risk of nearly 40 per cent. The median survival is also 5 years shorter than of a woman with optimal risk factors.

The influence of risk factors on the lifetime risk has been further elaborated in a more recent study. In that study all Framingham participants who were free of atherosclerotic CVD at age 50 were included.

 


Related Discussions:- Describe lifetime risk estimation

Illustrate the horizons in detail, Illustrate the Horizons in detail 'O...

Illustrate the Horizons in detail 'O'  is the  organic horizon  formed from t he organic litter derived from plants and animals and fresh or partially decomposed organic materi

How boron affect the the synthesis of proteins, How boron affect the the sy...

How boron affect the the synthesis of proteins ? Inadequate availability of boron tends to increase the loss of phosphorus from plant roots and also affects the synthesis of pro

What are the intermediate hosts of plasmodium, What are the intermediate an...

What are the intermediate and the definitive hosts of the plasmodium? In the life cycle of the plasmodium humans are the middle hosts (where asexual reproduction takes place) a

After purchasing - nursing software, After Purchasing The following po...

After Purchasing The following points should be considered for after purchase facilities. Avail of any training the software engineer or vendor may provide, even if it

Control of radio-pollution , (i)        Area uses or perm...

(i)        Area uses or permit exposure to radiation should be Marked' Restricted Area 'or Radiation zone etc. (ii)        Avoid x-rays of chest and lower back in routine physic

What is mineral absorption, Define Mineral Absorption? NDOs affect main...

Define Mineral Absorption? NDOs affect mainly calcium/magnesium absorption and balance. Acidification of colonic contents increases the concentration of ionized minerals, parti

Clathrin-coated pits and vesicles, Clathrin-coated pits and vesicles are in...

Clathrin-coated pits and vesicles are included in both the endocytosis   of material   at the plasma membrane and the exocytosis of proteins from the Golgi   apparatus.  Electron

What is the likely function of the snf gene, In yeast, a new mutation calle...

In yeast, a new mutation called suc was recently discovered.  The suc mutant cannot use sucrose as a source of carbon, and will not grow if the culture medium contains only sucrose

Which of structures is the nuclear membrane composed, Q. which of structure...

Q. which of structures is the nuclear membrane composed? Eukaryotic cells have nucleus delimited with two juxtaposed membranes that continue with the membrane of the endoplasmi

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd