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A protein that is normally a single-pass transmembrane protein is absent from the cell surface of the mutant cell line YTM-15. When labeled so that the protein can be localized, you find that this protein is now secreted by the cell. Analysis of the amino acid sequence of the transmembrane protein in question reveals sequence changes that could lead to the observed phenotype. The amino acid substitutions lead to alterations in the ER signal sequence and the stop-transfer sequence. In addition, YTM-15 cells exhibit a point mutation in the gene encoding signal peptidase. Only one mutation is consistent with the observed phenotype. What is the underlying cause of the mutant trait? Explain your reasoning.
Q. What is the hematopoiesis? Hematopoiesis is the formation of blood cells with other constituent elements of the blood. Q. Where does hematopoiesis occur? Hematopoies
What is a vesicle? A vesicle is a relatively minute intracellular, membrane-enclosed sac that keeps or transports substances
Define the Disorders due to the iodine deficiency? Mild goitre, i.e., a larger thyroid gland than normal. The mildest form of goitre ranges from those only detectable by to
What is the function of the citric acid cycle? The hnction ofthe citric acid cycle can be discussed as follows. The intermediates of citric acid cycle are used as precursor
Explain Carbohydrates - Nutritions? Liberal amounts of carbohydrates should be given i.e. around 60% to 65% of the total energy. However, care must be taken regarding the maxim
Q. Which is the brain region that receives conscious sensory information? Which is the brain region that triggers the voluntary motor activity? In the brain conscious sensory i
Study of Plsmodium
Vasoactive substances such as Endothelium Derived Relaxing Factors (EDRF). Prostacyclin and Endothelin can be formed in the vascular endothelium. Endothelial dysfunction can lead t
Briefly explain how amniocentesis and chorionic villi sampling are used in genetic screening. A small sample is removed from the amniotic fluid surrounding the fetus or from t
Define Tissue Distribution and Regulation of Calcium Concentration? As already discussed, development and preservation of bone mass is quantitatively an important function of c
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