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A protein that is normally a single-pass transmembrane protein is absent from the cell surface of the mutant cell line YTM-15. When labeled so that the protein can be localized, you find that this protein is now secreted by the cell. Analysis of the amino acid sequence of the transmembrane protein in question reveals sequence changes that could lead to the observed phenotype. The amino acid substitutions lead to alterations in the ER signal sequence and the stop-transfer sequence. In addition, YTM-15 cells exhibit a point mutation in the gene encoding signal peptidase. Only one mutation is consistent with the observed phenotype. What is the underlying cause of the mutant trait? Explain your reasoning.
Cholesterol is the precursor of the five major classes of steroid hormones.The synthesis of steroid hormones is initiated by the removal of a six-carbon unit from carbon 20 of
Why is meiosis important for the maintenance of the normal quantity of chromosomes of a species with sexual reproduction? A reduction to a half of the maximum normal quantity o
Q. What are the male pronucleus and the female pronucleus? The female pronucleus is the proper haploid nucleus of the egg cell and Male pronucleus is the haploid nucleus of the
Explain Micafungin sodium Micafungin sodium (Mycamine - Astellas), the second echinocandin antifungal1 to become available in the US, has been approved by the FDA for intraveno
Determine sequence weights for the sequences ACTA, ACTT, CGTT, and AGAT by using Thompson, Higgins, and Gibson method
Explain Monascus species Most of the reports of food colourants from microbial sources involve Monascus species, particularly Monascus purpureus, followed by Rhodotorula speci
Spring overturn - Overturn In spring and early summer season the increased solar radiation melts the ice cover, which, as it attains a temperature of 4° Celsius, becomes dense
Trypsin Trypsin is secreted in the inactive form trypsinor - which is converted into the active form trypsin by the enzyme enterokinase secrated by the duodenal mucosa.
Q. Which is the cell organelle that is specializing in aerobic respiration? The mitochondria are cell organelles that are specialized in aerobic respiration. Q. Of which ma
Synthetic Conduits Dacron, Polytetra fluro ethylene (PTFE) and polyglycolic acid grafts have extremely poor results and are not used any more.
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