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A protein that is normally a single-pass transmembrane protein is absent from the cell surface of the mutant cell line YTM-15. When labeled so that the protein can be localized, you find that this protein is now secreted by the cell. Analysis of the amino acid sequence of the transmembrane protein in question reveals sequence changes that could lead to the observed phenotype. The amino acid substitutions lead to alterations in the ER signal sequence and the stop-transfer sequence. In addition, YTM-15 cells exhibit a point mutation in the gene encoding signal peptidase. Only one mutation is consistent with the observed phenotype. What is the underlying cause of the mutant trait? Explain your reasoning.
Explain about Diabetes mellitus Diabetes mellitus (DM) has relation with all the systems of our body. With some systems it has direct relationship, while with others it has in
Mention causes of implant failure due to improper implant selection. Implant selection errors : a) Improper implant type in improper bone type. b) Improper length, width
What are stomata? How do these structures participate in the plant transpiration? Stomata (singular, stoma) are small specialized passages for water and gases there in the epid
Infraorbital nerve and vessels The infraorbital nerve exits through the infraorbital foramen. This foramen and the neurovascular contents are within 5 to10mm of extremely resor
what is relationship between numbers CPH in photon and frequency of photon? Answer; the photon contains n CPH and its energy is E=hν, when photons energy increases that the num
What is Venous Hum in heart dieases? Characteristic: Continues sound with diastolic component often a higher pitched and louder than the systolic, best heard just above the c
why does each muscle need an antagonistic partner
An egg osmometer Place some dilute hydrochloric acid or strong vinegar in a shallow dish, likeas a saucer, to a depth of about one centimetre. Hold the large end an egg in the
Explain Fetal Development? The medical profession divides pregnancy into three-month stages called trimesters. At the end of the first trimester, the fetus is only about 5 cm l
CLASSIFICATION OF HABITUATING DRUGS - There are a large number of drugs on which people become dependent. These are classified into 2 main categories - (i) Psychotropic d
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