Demonstrate the cause of the mutant trait, Biology

Assignment Help:

A protein that is normally a single-pass transmembrane protein is absent from the cell surface of the mutant cell line YTM-15. When labeled so that the protein can be localized, you find that this protein is now secreted by the cell. Analysis of the amino acid sequence of the transmembrane protein in question reveals sequence changes that could lead to the observed phenotype. The amino acid substitutions lead to alterations in the ER signal sequence and the stop-transfer sequence. In addition, YTM-15 cells exhibit a point mutation in the gene encoding signal peptidase. Only one mutation is consistent with the observed phenotype. What is the underlying cause of the mutant trait? Explain your reasoning.


Related Discussions:- Demonstrate the cause of the mutant trait

What is the hematopoiesis, Q. What is the hematopoiesis? Hematopoiesis ...

Q. What is the hematopoiesis? Hematopoiesis is the formation of blood cells with other constituent elements of the blood. Q. Where does hematopoiesis occur? Hematopoies

What is a vesicle, What is a vesicle? A vesicle is a relatively minute ...

What is a vesicle? A vesicle is a relatively minute intracellular, membrane-enclosed sac that keeps or transports substances

Define the disorders due to the iodine deficiency, Define the Disorders due...

Define the Disorders due to the iodine deficiency? Mild goitre, i.e., a larger thyroid gland than normal. The mildest form of goitre ranges from those only detectable by to

What is the function of the citric acid cycle, What is the function of the ...

What is the function of the citric acid cycle? The hnction ofthe  citric acid cycle can be discussed as  follows. The  intermediates of citric acid cycle are used as  precursor

Explain carbohydrates - nutritions, Explain Carbohydrates - Nutritions? ...

Explain Carbohydrates - Nutritions? Liberal amounts of carbohydrates should be given i.e. around 60% to 65% of the total energy. However, care must be taken regarding the maxim

Brain region that receives conscious sensory information, Q. Which is the b...

Q. Which is the brain region that receives conscious sensory information? Which is the brain region that triggers the voluntary motor activity? In the brain conscious sensory i

Endothelium derived relaxing factors, Vasoactive substances such as Endothe...

Vasoactive substances such as Endothelium Derived Relaxing Factors (EDRF). Prostacyclin and Endothelin can be formed in the vascular endothelium. Endothelial dysfunction can lead t

Briefly explain how amniocentesis used in genetic screening, Briefly explai...

Briefly explain how amniocentesis and chorionic villi sampling are used in genetic screening. A small sample is removed from the amniotic fluid surrounding the fetus or from t

Tissue distribution and regulation of calcium concentration, Define Tissue ...

Define Tissue Distribution and Regulation of Calcium Concentration? As already discussed, development and preservation of bone mass is quantitatively an important function of c

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd