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A protein that is normally a single-pass transmembrane protein is absent from the cell surface of the mutant cell line YTM-15. When labeled so that the protein can be localized, you find that this protein is now secreted by the cell. Analysis of the amino acid sequence of the transmembrane protein in question reveals sequence changes that could lead to the observed phenotype. The amino acid substitutions lead to alterations in the ER signal sequence and the stop-transfer sequence. In addition, YTM-15 cells exhibit a point mutation in the gene encoding signal peptidase. Only one mutation is consistent with the observed phenotype. What is the underlying cause of the mutant trait? Explain your reasoning.
Head - Structure of the Sperm It exhibits a diversity of shapes in different animal groups, e.g., spherical (teleost fishes), rod or lance shaped (amphibians), spirally twist
Why Pregnancy and lactation are critical stages in lifecycle? You must be aware that the situation of women is far from optimal and it is necessary to give attention to their n
MN blood group in humans is under the control of two co-dominant alleles M and N. Blood typing results of a population having of 1349 individuals showed that: - 363 persons h
Three charges are arranged as shown in the figure below. Find the magnitude and direction of the electrostatic force on the charge q = 4.78 nC at the origin. (Let r12 = 0.260 m.)
Distinct types of proteins Two distinct types of proteins are known: fibrous and globular proteins. Fibrous proteins are insoluble in water and are physically tough, which
What are the main events of the final mitotic period? The final mitotic phase is telophase. In telophase the following events happens: decondensation of chromosomes, every set
Define Strategies for to overcome from alzheimer's disease? Some of these, based on the stage of the disease and individual needs are: a. supervising meal times with minimal
Explain Nutrient Requirement and Dietary Management? You must have understood by the discussion above that by the end of the flow phase, the patient usually is well hydrated an
Lipolysis What do we mean by lipolysis? Hydrolysis of ester bonds in lipids is called lipolysis. This may occur by enzyme action or by heat and moisture, resulting in the liber
Define Systematic Botany - Taxonomy? We will now learn something mare about systematic botany. The early recognition of harmful and useful plants was the beginning of systemati
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