Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Golgi apparatus, GOLGI  APPARATUS It is a complex cyctoplasmic stru...

GOLGI  APPARATUS It is a complex cyctoplasmic structure made up of smooth membrane saccules or cisternae, a network of tubules with vessicles and vacuoles, which take part i

Eye ball, WALL OF EYE BALL - Outer to inner 3 layers present. 1. Scl...

WALL OF EYE BALL - Outer to inner 3 layers present. 1. Sclerotic or fibrous Tunic 2. Choroid or uvea or vescular Tunic. 3. Retina or neuro sensory tunic. Sclerotic

Differential reinforcement of low response rate, Differential reinforcement...

Differential reinforcement of low response rate (DRL) This is used to encourage low rates of responding. Example: "If you ask me for a potato chip no more than once every 10 mi

Neural impulse is transmitted from one cell to another, What is the structu...

What is the structure through which the neural impulse is transmitted from one cell to another? What are its parts? The structure by which the neural impulse passes from one c

Characteristic features of phylum arthropoda, Characteristic Features of Ph...

Characteristic Features of Phylum Arthropoda Well-developed muscular system along with striated muscles attached to the exoskeleton, and visceral organs having smoot

Relationship of different systems in diabetes mellitus, Describe the relati...

Describe the relationship of different systems in diabetes mellitus Diabetes Mellitus has direct relationship with endocrine system, especially with endocrine part of the panc

Describe the tailored to the individual patient, Describe the tailored to t...

Describe the tailored to the individual patient? Patent ductus arteriosus (PDA) interruption (surgical or transcatheter intervention): It is a curative procedure. Atrial

What is the action mechanism of the antibiotic penicillin, Penicillin, disc...

Penicillin, discovered by the Scottish doctor Alexander Fleming, in 1928, is a drug that inhibits enzymes essential for the synthesis of peptidoglycans, a constituent of the bacter

Can you define striated cardiac muscle tissue, Q. Of which kind of tissue i...

Q. Of which kind of tissue is the heart made? How is this tissue oxygenated and nutrified? The heart is made of striated cardiac muscle tissue and the heart muscle is called th

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd