Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

History - assessment of patents with cardiovascular probems, History P...

History Past and present history of cardiovascular problems of patient & family. History of chest pain, shortness of breath, fatigue, abnormal skin colour, dizziness, vertigo

Percussion - criteria for endosteal implants, Percussion - criteria for end...

Percussion - criteria for endosteal implants? It is neither an indicator of clinical health nor of rigid fixation. Ringing sound that occurs on percussion corresponds to the pr

Procedures for diagnosis - restriction enzyme analysis, R e striction...

R e striction enzyme analysis: The restriction endonuclease analysis of viral DNA fragments or DNA fingerprinting discovered in 1970s has revolutionized the study o

Importance of counselling for diabetic patient, Q. Importance of counsellin...

Q. Importance of counselling for diabetic patient? Diabetes is a life-long illness. Life style modification and precautions taken by the patient can prevent complications and i

Explain the pipettes - food microbiology, Explain the Pipettes - Food Micro...

Explain the Pipettes - Food Microbiology? Sterile glass pipettes or disposable pipettes can be used for transferring the known volume of liquid or culture aseptically. Steriliz

Explain about chlorophylls - natural pigments, Explain about Chlorophylls ...

Explain about Chlorophylls Chlorophylls are used as colourants in a range of foodstuffs and both natural chlorophyll (containing magnesium as the central metal ion) and 'coppe

Psyiology, I need help with p-p, q-q and r-r intervals and heart rates

I need help with p-p, q-q and r-r intervals and heart rates

Mitochondrial membrane, Fatty acid breakdown happens in the cytosol of prok...

Fatty acid breakdown happens in the cytosol of prokaryotes in plants in peroxisomes and in the mitochondrial matrix of all other eukaryotes.  By entering the mitochondrial matrix,

Uptake of iron by enterocytes - non-haem iron absorption, Define Uptake of ...

Define Uptake of iron by enterocytes - Non Haem Iron Absorption? Ferrous iron traverses the brush border of the intestine better than the ferric iron. The mechanism of absorpti

Explain glycogen storage diseases, Glycogen Storage Diseases Glycogen  ...

Glycogen Storage Diseases Glycogen  storage diseases are caused by  genetic defects that result  in  deficiencies in  certain enzymes of  glycogen metabolism. These deficiencie

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd