Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Porifera, how to write character of porifera

how to write character of porifera

Brain, why left brain controls right side of the body and right brain contr...

why left brain controls right side of the body and right brain controls left side of the body....?????

Explain what is inversion, Explain what is Inversion ? Inversion is ano...

Explain what is Inversion ? Inversion is another way in which genetic recombination can occur, as seen below. In this case, the change occurs within a chromosome, rather than b

Explain observation or inference required for osazone test, Explain Observa...

Explain Observation or Inference required for osazone test? 1. Crystals of different shapes will be seen. Glucose and fructose give needle shaped crystals and galactose gives f

Explain consultant dietitians, Explain Consultant dietitians Consultant...

Explain Consultant dietitians Consultant dietitians work under contract with healthcare facilities  or  in  their own private practice. They perform nutrition screenings  for

What is the goal of biological classification, The goals of biological clas...

The goals of biological classification The world of animal diversity is quite complex and it requires an ability to recognise similarities and differences among organisms. Class

Main factors that affect the growth of a population, Q. What are the main f...

Q. What are the main factors that affect the growth of a population? The major factors that make populations grow are births and immigration. The major factors that make popula

What do you mean by pollen, Q. What do you mean by pollen? Pollen grain...

Q. What do you mean by pollen? Pollen grains are the male gametophytes of the phanerogamic (flowering) plants So within the pollen grains the male gametes of these plants are f

Determine pull-ups test for check the body strength, Determine Pull-ups tes...

Determine Pull-ups test for check the body strength? This test is also done to measure upper body strength or endurance by maximum number of pull-ups completed. Subject hangs f

Reviews - assurance engagements, Reviews - Assurance engagements The o...

Reviews - Assurance engagements The objective of financial statements of a review is to enable an auditor to state where, on the essential of procedures that do not give all t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd