Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Physiological characteristics of molds, Q. Physiological Characteristics of...

Q. Physiological Characteristics of molds? The physiological characteristics of molds will be reviewed only briefly here and will be discussed in more detail subsequently. Mois

Why are additives used in foods?, Normal 0 false false fal...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Define brain stem, Define Brain Stem Brain stem consists of three parts...

Define Brain Stem Brain stem consists of three parts i.e. midbrain, pons and medulla oblongata. The functions of the Brain Stem are: Brain stem contains points of cranial

What do you mean by cold deserts, What do you mean by Cold Deserts? Col...

What do you mean by Cold Deserts? Cold deserts cover a vast area north of the Himalayan ranges forming an ecosystem with exceptionally low temperatures which may reach - 75°C a

#title, WHAT IS THE FUNCTION OF CELL COAT

WHAT IS THE FUNCTION OF CELL COAT

Explain in brief about leukotrienes and prostaglandins, Leukotrienes and pr...

Leukotrienes and prostaglandins are produced only when the mast cell undergo degranulation and enzymatic break down of phospholipids in the plasma membrane. The effects formed b

Define ferricyanide-cyanide reagent or drabkin''s solution, Define Ferricya...

Define Ferricyanide-cyanide reagent or Drabkin's solution? Dissolve 0.2 g potassium ferricyanide, 0.05 g potassium cyanide and 1.0 g sodium bicarbonate in about 100-1 50 ml dis

How are parasites classified, Concerning the number of hosts how are parasi...

Concerning the number of hosts how are parasites classified? Parasites that need only one host are known as monoxenous parasites. Parasites that need more than one host for th

How the visual images are projected, Since the visual images are projected ...

Since the visual images are projected in an inverted manner on the retina why don't we see things upside down? As the crystalline lens is a convex spherical lens it forms inver

Experiments do not support the hypothesis, If experiments do not support th...

If experiments do not support the hypothesis, the hypothesis is always rejected or wrong. True or False?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd