Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Phylum annelida, what so special for phylum annelida

what so special for phylum annelida

Tiny fraction of this water which is retained by the plant, Most of the wat...

Most of the water taken up by a plant passes through it and is evaporated to the atmosphere. What use is made of the tiny fraction of this water which is retained by the plant?

Propose an experiment to test, Can enhancers work in Trans? That is, can an...

Can enhancers work in Trans? That is, can an enhancer on one piece of DNA activate a promoter on another piece of DNA? Propose an experiment to test this. Be sure to discuss any ap

Explain the term tracheostomy, Explain the term Tracheostomy ? If the d...

Explain the term Tracheostomy ? If the duration of mechanical ventilation is likely to be prolonged, it is wise to do an early tracheostomy. Otherwise, a tracheostomy is usuall

Agro industrial-animal wastes, Animal wastes Large quantities of anima...

Animal wastes Large quantities of animal wastes are available in the country but generally they are low in nutrient content with poor feeding value to the animals. However, po

Explain ventricular septal defect in details, Explain Ventricular Septal De...

Explain Ventricular Septal Defect in details ? Indications of surgery :  Some VSDs close spontaneously or become smaller in size. This has to be taken into consideratio

Needle and sharp instrument safety, Needlestick/sharp instrument injuries a...

Needlestick/sharp instrument injuries are of major concern to health care workers. All of the significant exposures reported in the academic year 2003/04 in our Faculty, were injur

Simple lipids, SIMPLE  LIPIDS They are lipids formed of fatty acids an...

SIMPLE  LIPIDS They are lipids formed of fatty acids and alcohol without any additional group. e.g. fats or true fats,wax,cutin, suberin. Simple lipids are mainly of 2 types

What do you understand by serial homology, What do you understand by Serial...

What do you understand by Serial homology? Metamerization results in a linear series of segments which share a common embryonic origin. Ancestrally, all metameres were identica

Respective constituents of cell walls in bacteria , What are the major resp...

What are the major respective constituents of cell walls in bacteria, protists, fungi and plants? Ans) In bacteria cell wall is made of peptidoglycans; between protists algae ha

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd