Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

What is antimicrobial resistance, Question 1 What is antimicrobial resista...

Question 1 What is antimicrobial resistance? List the reasons for antimicrobial resistance. Explain why antimicrobial resistance is a global concern. Add a note on various mechani

Explain cognitive - behavioural approaches, Cognitive - Behavioural Approac...

Cognitive - Behavioural Approaches They includepsychoeducatiorzal and rational-emotive  therapy. The goal is to identify problem behaviour and irrational beliefs and then to de

Explain how a cell produces and releases proteins, Explain how a cell produ...

Explain how a cell produces and releases proteins. Proteins are made on ribosomes and packaged into vesicles by the Golgi apparatus. The vesicles move to the cell membrane and

Determine the number of cell clusters, A cellular system has a total of 500...

A cellular system has a total of 500 duplex voice channels. The service area is divided into 150 cells. Suggest a three different cluster size (N) values. In each case, determine

Community gradients and boundaries, Community Gradients and Boundaries ...

Community Gradients and Boundaries It is often difficult or impossible to determine where one community ends and the next begins. Many communities, in fact, grade continuousl

Define mechanism for copper absorption, Define Mechanism for Copper Absorpt...

Define Mechanism for Copper Absorption? As in the case of other minerals, copper absorption appears to occur by two mechanisms: i) Saturable active mechanism, which operates

Cryptosporidiosis, Cryptosporidiosis Cryptosporidiosis, a protozoan diseas...

Cryptosporidiosis Cryptosporidiosis, a protozoan disease of the intestinal tract, is caused by Cryptosporidium parvum and Cryptosporidium muris. It infects man, dog, cat, calves,

What is the choice of a prophylactic agent, Choice of a prophylactic agent ...

Choice of a prophylactic agent An effective prophylactic regimen should be directed against the most likely infecting organisms, but need not eradicate every potential pathogen

Which are the beings that form the kingdom animalia, Which are the beings t...

Which are the beings that form the kingdom Animalia? What are the two big groups into which this kingdom is divided? The kingdom Animalia is the animal kingdom. Commonly the ki

Digestive system - liver, LIVE R (HEPAR) - Largest gland of body. W...

LIVE R (HEPAR) - Largest gland of body. Weighing 1.6 kg. Form 1/40 of the body weight. Bio-chemical laboratory. Bussiest part in whole river of life. Dark reddish brown

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd