Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Explain phenotypical traits, Why is not Mendel's second law always valid fo...

Why is not Mendel's second law always valid for two or more phenotypical traits of an individual? Mendel's second law, or the law of the independent assortment, is valid for g

Zoology, differences regarding Tiger Planaria and the Iridescent Phyllodoce...

differences regarding Tiger Planaria and the Iridescent Phyllodoce

Determine the atp-sensitive potassium channel, ATP-sensitive potassium chan...

ATP-sensitive potassium channel A. The channel is a spanning protein with a receptor site for ATP located on an intracellular region of the protein. B. When blood plasma lev

#title.humans and environment., what are the two main pollutants that contr...

what are the two main pollutants that contribute to aci rain

Procedure for estimation of vitamin c - colorimetric method, Define Procedu...

Define Procedure for estimation of vitamin c - colorimetric method? Carry out the experiment following the instructions given herewith: 1. Prepare a series of tubes for blan

Experiment turn out differently then you expected, If the results of an exp...

If the results of an experiment turn out differently then you expected, what does that mean? A. The experiment was a failure B. You did not follow scientific method C. You should e

Define etiology - anorexia nervosa, Define Etiology - Anorexia Nervosa? ...

Define Etiology - Anorexia Nervosa? The exact cause of eating disorders is not known. It is multi factorial in origin in which the personality of the patient, family relationsh

Describe pharmacologic agents in amyl nitrite, Describe Pharmacologic Agent...

Describe Pharmacologic Agents in amyl nitrite ? Amyl Nitrite : It produces vasodilatation which initially results in marked fall in BP and in the next 30-60 seconds there is

Platyhelminthes, tell me the general characters of monopisthocotylea

tell me the general characters of monopisthocotylea

Explain about lyophilic, Explain about lyophilic If the affinity betwee...

Explain about lyophilic If the affinity between the dispersed phase and the medium is high, the dispersed phase is said to be lyophilic (solvent loving) or hydrophilic, in the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd