Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

What is subphylum vertebrata explain, What is Subphylum Vertebrata explain?...

What is Subphylum Vertebrata explain? This large group of animals takes its name from its distinguishing feature: the vertebral column, or the backbone. The backbone made of se

Define central nervous system, Q. Define Central nervous system? The ne...

Q. Define Central nervous system? The nervous system begins as a simple tube during embryonic development (then anterior part expands and also ventricles are formed).  Foreb

Differences between single-unit and multi-unit muscles, DIFFERENCE S BETWE...

DIFFERENCE S BETWEEN SINGLE-UNIT AND MULTI-UNIT SMOOTH MUSCLES     Single-unit Smooth Muscles   Multi-uni t Smooth Muscles

Explain venous thromboembolism, Venous Thromboembolism Prolonged immob...

Venous Thromboembolism Prolonged immobilization (>8 hours) increases the risk of lower extremity deep vein thrombosis (DVT), particularly in travelers with risk factors for th

Heterotrophs, Collect images of heterotrophs and make a Powerpoint Presenta...

Collect images of heterotrophs and make a Powerpoint Presentation on them

Reproduction, briefly deccribe the eggs snd follicles

briefly deccribe the eggs snd follicles

Why his muscles so sore and feeling weak, Yesterday, when Eric returned hom...

Yesterday, when Eric returned home from jogging, he was breathing heavily, sweating profusely, and complained that his legs ached and felt weak. He took a drink of Gatorade and too

Dietary management of oesophagitis, Q. Dietary Management fo oesophagitis? ...

Q. Dietary Management fo oesophagitis? Providing adequate nutrition support may require emphasis of different aspects during acute and chronic oesophagitis. In acute phase,

What would happen to the neuron, If neurons are exposed to a chemical agent...

If neurons are exposed to a chemical agent that prevents the NA+ channels from opening, what would happen to the neuron? What would happen if the K+ channels were inhibited? What d

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd