Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Technique of assessment of growth and development, TECHNIQUE OF ASSESSMENT ...

TECHNIQUE OF ASSESSMENT OF GROWTH AND DEVELOPMENT Measurement of physical growth in children is a key element in evaluation of the health status of children. Physical grow

What is the mendel observations and conclusions, How would Mendel's observa...

How would Mendel's observations and conclusions have been dissimilar if many of the characteristics he studied, such as seed color and seed texture, had been controlled by genes lo

Importance of reproduction, Importance of reproduction Reproduction ...

Importance of reproduction Reproduction is an important life process in animals and plants. Reproduction is the ability of an organism to produce new generation of indivi

Define foaming properties of proteins, Define Foaming Properties, Binding o...

Define Foaming Properties, Binding of Flavour and Other Substances? To understand the foaming properties of proteins, we need to know some basic aspects of foam foods. Foam foo

Why is water conservation in c3 c4 and cam plants important, Why is water c...

Why is water conservation in c3 c4 and cam plants important? Cam stands for Crassulacean acid metabolism. C3 and C4 conserve less water than Cam plants. Actually, C4 plan

Explain pyruvate kinase, Pyruvate kinase catalyzes the third irreversible m...

Pyruvate kinase catalyzes the third irreversible move in glycolysis.  It is activated by fructose 1, 6-bisphosphate.  The ATP and amino acid alanine allosterically inhibit the enzy

Explain some side effects of carbohydrate loading, Explain some side effect...

Explain some side effects of carbohydrate loading? Some potential side effects of carbohydrate loading are: Muscle , stiffness Diarrhoea Chest Pain Depres

Treatment and management of chronic bronchitis, Treatment and Management ...

Treatment and Management Diagnosis History, physical examination  Radiological examination chest X-ray  Sputum studies, CIS, smear,  ABG analysis-restin

Proteins of plant origin - vegetable proteins, Proteins of Plant Origin ...

Proteins of Plant Origin Vegetable Proteins: Fresh vegetables are not considered to be a very good source of proteins. On fresh weight basis, the average protein content of s

The chance of fertilisation in humans, Explain why the chance of fertilisat...

Explain why the chance of fertilisation in humans is restricted to only a few days each month. Sperms can fertilise an ovum for up to about three days after entering the female

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd