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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
URETERS From hilum of each kidney emerges out a tube. Wall is thick. Lumen is star shaped. 28 cm. long. Transitional epithelium present in wall. Open in to urinary bla
explain five kingdoms?
What is Working of Mouth in human body? Food enters the digestive system through the mouth, where it is processed by the teeth and mixed with saliva, prior to being swallowed.
Darwin put fort the notion of the survival of the fittest. How do we define 'fittest'? The answer usually given is those who survive. So you can readily see that this is a circular
Q. What is an etiological agent of disease? The etiological agent of disease is the agent that causes the disease. It may perhaps a living being, substance or environmental fac
To "express" a gene is to make it to function properly. A gene which encodes a protein will, when expressed, be transcribed or translated to produce that particular protein. A gene
Explain the requirements of Special Stains? Special stains are required to make spores clearly visible. Different techniques like negative staining, dorner staining method, sch
When a fatty acid reacts with glycerol, the result is- Select one: a. Formation of an amide b. Formation of an ester c. Formation of hydrocarbon d. Formation of a th
Q. Define characteristic of Doppler Echocardiographic? Ans. Doppler findings of cardiac tarnponade are based on the following characteristic respiratory variations in intr
main external morphological feature that differentiates platyhelminthes from nematodes
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