Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Valuation of biodiversity, Q. Show the Valuation of Biodiversity? Serio...

Q. Show the Valuation of Biodiversity? Serious research in this field has only been recently initiated and the methodologies for valuation are still evolving. Important valuat

Levels of prevention, Family Centred Activities to Ensure Harmonious Relati...

Family Centred Activities to Ensure Harmonious Relationship: Between various members of  the family attitudes of mutual trust, love and respect for one another need  to be  fo

The middle course - classification of the river, The middle course - Classi...

The middle course - Classification of the river The middle course of the river occurs over the foothill belt where the velocity or water is comparatively less which moves a li

Explain how will you perform ward radiography?, Question 1 Explain how ...

Question 1 Explain how will you perform ward radiography? Question 2 Discuss the radiographic projections recommended for imaging the first to third cervical vertebr

Problems of osmoregulation, Problems of Osmoregulation The water, some...

Problems of Osmoregulation The water, some inorganic salts, nutrient molecules are some of the important components of the body fluids. It is essential for the animals to main

Arthropods - regeneration in invertebrates, Arthropods - Regeneration in In...

Arthropods - Regeneration in Invertebrates Among arthropods like insects, crustaceans, centipedes, scorpions and spiders, the capability of regeneration is low or not present.

Systmetic, Relation between taxonomy and ecology

Relation between taxonomy and ecology

Explain the chemical methods for control of microorganisms, Explain the Che...

Explain the Chemical Methods for Control of Microorganisms? Different chemicals can be used which can act as disinfectant, antiseptics or even chemical sterilants. These are:

Define general protection in the laboratory, Define General protection in t...

Define General protection in the Laboratory? You are required to wear a laboratory coat at all times in the laboratory. It is sensible to buy one of good quality and to launder

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd