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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
Define the Indications for Root-End Resection Apicoectomy a) Persistent..... "Exactly the SAME of Curettage except the biopsy. b) When the apical portion of the root canal s
in what part of the human body aschelminthes found?
Fire Protection - Factors Affecting Occupational Health Fire protection and extinguishing devices require to be installed at proper places in the work place and proper notices
Define Blank titration for Determination of the Iodine Number of Lipids? Using an autopipette, measure 25 ml of Hanus iodine reagent accurately and transfer into a 250 ml iodin
who proposed trinomial system of classification? in ALLEN modules ans is Huxley & Stricklandt but in AAKASH its given Lamarck so what is correct?
Explain the taxonomy of Lamarck? Lamarck's taxonomy was mainly static in nature and his classification does not show its true value to the development of modern taxonomy. His m
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What is osseointegration The smaller the devital zone that forms around the implant subsequent to the surgical trauma, the more likely rigid fixation will occur. The aim is to
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Activated carbon has a much higher adsorption capacity than other materials. Carbon adsorbs objectionable odours, flavours, organic compounds and many hazardous chemicals. There
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