Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Obelia, Economic importance of obelia

Economic importance of obelia

How is striped pattern of the striated muscle cells formed, How is the stri...

How is the striped pattern of the striated muscle cells formed? The functional units of the muscle fibers are the sarcomeres. Within the sarcomeres blocks of myosin and actin

Chromosome jumping, Chromosome jumping is the technique whereby one begins...

Chromosome jumping is the technique whereby one begins with a piece of DNA from one area of a chromosome, and obtains clones from nearby areas without cloning everything in betwee

What kinds of mutation in disease-causing bacteria, What kinds of mutation ...

What kinds of mutation in disease-causing bacteria might make them more dangerous Pathogenic bacteria will become more dangerous to us if mutations make them more virulent or r

Mineral availability of organic mineral complexes, Mineral availability of ...

Mineral availability of organic mineral complexes A number of mineral chelates and complexes are available from a variety of manufacturers. A chelate is described as a metal c

Digitalis toxicity, Symptoms of digitalis toxicity include anorexia, nausea...

Symptoms of digitalis toxicity include anorexia, nausea, headache, blurring or yellowing of vision, and disorientation. Cardiac toxicity may take the form of atrioventricular condu

Explain what is genetic engineering, Explain brifly what is Genetic Enginee...

Explain brifly what is Genetic Engineering ? Genetic Engineering : Engineering techniques have been used in agriculture and horticulture for centuries. Certain plants or ani

Phylum protozoa, what arr the economic importance of phylum protozoa

what arr the economic importance of phylum protozoa

World conservation strategy proposes various steps , WORL D CONSERVATION S...

WORL D CONSERVATION STRATEGY PROPOSES THE FOLLOWING STEPS - 1.       Preservation of critical habitats. 2.       Protection of wild life in situ (in natural habitats) as we

State the disorders of sleep, State the Disorders of sleep The need for...

State the Disorders of sleep The need for sleep varies considerably from one person to another, as well as in the same person at different stages of life. We have all been told

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd