Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Define interaction of folate with vitamin b12, Define interaction of folate...

Define interaction of folate with vitamin B 12 ? Vitamin B 12 : For the conversion of folic acid to folinic acid, vitamin B 12 is required. Vitamin BIZ deficiency caus

What is gastrulation, What is gastrulation? How during gastrulation are the...

What is gastrulation? How during gastrulation are the first two germ layers formed? What are these germ layers? Gastrulation is the process by which a portion of the blastula w

Ideal characteristics of blood pump-cardio pulmonary bypass, Blood Pump :  ...

Blood Pump :  Ideal Characteristics 1) I should be able to pump up to seven litres of blood per minute. 2) It should not damage cellular and cellular components of blo

Biosynthesis of amino acids, Microorganisms and Plants can synthesize all o...

Microorganisms and Plants can synthesize all of the 20 standard amino acids. Mammals, furthermore, cannot synthesize all 20 and must obtain some of them in their diet.  Those  amin

Osteogenesis - production of bone on soft tissue, Osteogenesis: Production ...

Osteogenesis: Production of Bone on Soft Tissue Now that we know the players in bone adaptation, we will look at the ways in which bone may be created and modified. There are t

Explain glucocorticoids, Explain Glucocorticoids The adrenal cortex se...

Explain Glucocorticoids The adrenal cortex secretes the glucocorticoids which  increase gluconeogenesis by increasing hepatic intake of amino acids accompanied by increased ac

Photosynthesis, How does the placement of veins help to carry out their fun...

How does the placement of veins help to carry out their function of transporting materials to and from the leaf ?

Temperature - seed dormancy, Temperature - Seed Dormancy Low temperatu...

Temperature - Seed Dormancy Low temperature treatment is an essential prelude to germination in many seeds, and high temperature may be inhibitory at the time of germination.

Chordata, Structure of plasmodium

Structure of plasmodium

Determine the categories of drug and nutrient relationship, Determine the C...

Determine the Categories of Drug and nutrient relationship? Drug and nutrient relationship can be categorized into two aspects: 1. Effect of nutrition on drugs: the influenc

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd