Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Consistently overwatering a potted tomato plant, Consistently overwatering ...

Consistently overwatering a potted tomato plant will eventually kill it. Using the map, suggest why waterlogged soil results in plant death. O2 cannot reach respiring root cells. T

Explain about the qualitative tests for carbohydrates, Explain about the Qu...

Explain about the Qualitative Tests for Carbohydrates? This section will familiarize you with simple techniques and tests to identify carbohydrates in a laboratory. The objecti

Explain about conjugated proteins, Conjugated Proteins Conjugated prote...

Conjugated Proteins Conjugated proteins are composed of easy proteins combined with a non- proteinous substance.  The non-proteinous substance is known as prosthetic group o

Explain about the blanching - food processing, Explain about the Blanching ...

Explain about the Blanching - Food Processing? Blanching is used for variety of purposes. It is defined as a mild heat treatment applied to tissue (usually plant) prior to free

Define some precautions for estimation of amount of bacteria, Define some P...

Define some Precautions for Estimation of the Amount of Bacteria? 1. Dilution should be made carefully. 2. Use fresh sterile pipette for making each dilution. 3. Aseptic

Describe respiratory system , Describe Respiratory System? The respirat...

Describe Respiratory System? The respiratory system is responsible for the transport of oxygen and carbon dioxide from outside the body to and from the blood. This process is c

Compute the amount of nacl need, A saline drip is to be prepared for a lab ...

A saline drip is to be prepared for a lab experiment that is looking at hydration in lab rats. Calculate the amount of NaCl need to make 4 liters of a 0.9% solution.

Which disorders is most likely to underlie, A healthy, primiparous (first-t...

A healthy, primiparous (first-time) mother delivered a healthy infant several hours ago, but the mother has experienced postpartum hemorrhage. Which of the following disorders is m

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd