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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
Why Water and Electrolytes are important for exercise? Water and electrolytes are important for exercise performance as they maintain blood volume and osmolality, thermoregulat
Define the Cooper's Run (12 minute run) Method? To undertake this test, a 400 metre running track is required-marked every 100 m and a stop watch. The test comprises of noticin
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Intra Oral Periapical Radiographs These can either be taken conventionally or by the help of RVG (RADIO VISUO GRAPHY). RVG offers certain benefits over conventional X-Rays suc
ALCOHOLISM - Continual heavy consuming of alcohol is called alcoholism or drinking . Word alcohol is refered to C 2 H 5 OH or ethyl alcohol or ethanol or grain alcohol.
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