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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
Hounsfield Units: It is an arbitrary scale of gray values for CT. It is an indicator of bone density: - Trabecular bone has a range of 200 - Cortical bone has a range
Q. Prevention strategy for diverticular disease? The prevention strategy for the disease involves the following: • Eat a high-fiber diet (more than 15 g/day of crude fiber)
(1) From the above gateway reaction (entry clone and destination vector); (i) which plasmid will be selected for when transformed into E.coli (A or B) and why? (ii) which an
Describe about the stomach
wHAT IS 10um?
explain protozoa taxonomy
Flowering and Endogenous Rhythms The last four decades of studies in animals and plant physiology have clearly established the existence of a biological clock mechanism to me
Prostaglandins Prostaglandins belong to a subclass of lipids known as the eicosanoids because of their structural similarities to the C-20 polyunsaturated fatty acids, t
How are ecological interactions classified? Ecological interactions are divided as intraspecific or interspecific interactions and as harmonious or inharmonious interactions.
Metazoan Branches The Kingdom Animalia comprises all the multicellular animals (metazoans). These are divided into three branches: Mesozoa Parazoa Eumetazoa
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