Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Matter of gene control and imprinting, Differentiation is largely a matter ...

Differentiation is largely a matter of gene control and imprinting (CH3) plays a role, but ___ may also play a role.

Chronic aortic regurgitation-indications for surgery, Chronic Aortic Regurg...

Chronic Aortic Regurgitation :  Several factors have to be taken into account before recommending surgery. These include severity of symptoms and LV function. With evidence o

What are the pentoses, Q. What are the pentoses? To what organic group do t...

Q. What are the pentoses? To what organic group do the pentoses belong? Are nucleotides formed of only one kind of pentose? Carbohydrates are Pentoses made of five carbons. Deo

What is bioremediation, What is bioremediation? Bioremediation is the u...

What is bioremediation? Bioremediation is the use of microorganisms, as bacteria, protists and fungi, to degrade noxious substances turning them into non toxic or less toxic su

Define biogeographic realm, Q. Define biogeographic realm? Biogeographi...

Q. Define biogeographic realm? Biogeographic regions are large areas that contain characteristic assemblages of animals and plants, d elineated on account of natural barriers s

Difference between spermatogenesis and oogenesis, DIFFERENC E BETWEEN SPER...

DIFFERENC E BETWEEN SPERMATOGENESIS AND OOGENESIS - S.NO . SPERM A T OGENESIS OOGENESIS 1.   2.   3.

What is the diameter of this nucleus, By bombarding atoms in a thin metal s...

By bombarding atoms in a thin metal sheet with energetic particles, Rutherford found that most of the mass of an atom is concentrated inside a very small volume. What is the diamet

Define about the nutritional deficiencies, Define about the nutritional def...

Define about the nutritional deficiencies? The nutritional deficiencies which have been identified in the group of elderly are of total calories, protein, vitamin A, vitamin C,

Explain what is patent ductus arteriosus in details, Explain what is Patent...

Explain what is Patent Ductus Arteriosus in details? Figure : Anatomical location of PDA Patent Ductus Arteriosus (PDA) may be an isolated defect or may co-exist with

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd