Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Endocrine glands - prostaglandins, PROS T AGLANDIN S (PGS) - Beca...

PROS T AGLANDIN S (PGS) - Because they were first found in semen (which is produced partly by the prostate gland), they were named prostaglandins. Prostaglandins are d

Drawbacks of lamellar model, Drawbacks of Lamellar model This model ...

Drawbacks of Lamellar model This model does not explain the elasticity of PM. Although this model says that PM is elastic but it also states that head of lipid molecules is

Explain working of dietitians and nutritionists, Dietitians and nutritionis...

Dietitians and nutritionists Dietitians and nutritionists, who are associated with hospitals and clinics generally have regular work hours. At times, they may be required to wo

What is secretary diarrhoea, Q. What is Secretary diarrhoea? Secretary ...

Q. What is Secretary diarrhoea? Secretary diarrhoea: It is a result of active secretion OF electrolytes and water by the intestinal epithelium caused by bacterial and viral inf

Explain root amputation, Explain the Root amputation, Hemisectioning and Bi...

Explain the Root amputation, Hemisectioning and Bicuspidization Root amputation: removal of one or more roots of a multirooted tooth "upper teeth". Hemisectioning: surgic

Illustrate oil-bearing materials, Illustrate oil-bearing materials Oil...

Illustrate oil-bearing materials Oil contents for vegetable oil-bearing materials vary between 18% and 68% of the total weight of the seed, nut, kernel or fruit as indicated i

Explain the following terms in detail - homology, Explain the following ter...

Explain the following terms in detail - Homology, Homologous ? Structures that have a similar evolutionary origin however different functions. The wing of a bat and a whale's fl

Temperate deciduous forests, Going south of taiga you would reach the tempe...

Going south of taiga you would reach the temperate regions of the planet. These regions experience moderate temperatures on average that change during four distinct seasons. They h

Categories of drugs, CATEGORIES OF DRUGS - 1 . ...

CATEGORIES OF DRUGS - 1 . Anaesthetic - Produces anaesthesia 2. Analgesic - Reliev

Energy demand for sedentary or light activity lifestyles, Explain Energy de...

Explain Energy demand for Sedentary or Light Activity Lifestyles? These people have occupations that do not demand much physical effort, are not required to walk long distances

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd