Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Economic biology, Economic Biology: This is the study of useful plants and...

Economic Biology: This is the study of useful plants and animals or their products. Economic biology is referred to as economics and human biology. Economics or Human Biology can

Cavity development, A complete gut is sometimes called tube within a tube. ...

A complete gut is sometimes called tube within a tube. Why?

How to produce organic material from inorganic substances, What are the pro...

What are the processes that autotrophic beings use to produce organic material from inorganic substances? Autotrophic beings make organic material by photosynthesis or by chemo

Phospholipids - conjugated lipids, PHOSPHOLIPIDS Most abundant lipid...

PHOSPHOLIPIDS Most abundant lipid present in cell membrane, also called membrane lipid. It is made up of lipid & phosphoric acid. The basic phospholipid is phosphat

Agro industrial-processing of roughage, Processing of roughage Roughag...

Processing of roughage Roughages constitute the bulk of the ration of farm animals and these include green fodder (leguminous and non-leguminous), grasses, and various crop re

Seliwanoff test or resorcinol hydrochloric acid reaction, Define seliwano...

Define seliwanoff's Test or Resorcinol Hydrochloric Acid Reaction? seliwanoff's test is specific test for ketonic groups and therefore is positive for ketose sugars like fruc

After purchasing - nursing software, After Purchasing The following po...

After Purchasing The following points should be considered for after purchase facilities. Avail of any training the software engineer or vendor may provide, even if it

What are cerebrovascular accidents, Q. What are cerebrovascular accidents? ...

Q. What are cerebrovascular accidents? The Cerebrovascular accident (CVA), as well known as stroke, is the generic name given to infarction (tissue and cellular death by hypoxi

Simple squamous epithelium - stratified squamous epithelium, Q. How differe...

Q. How different is the simple squamous epithelium from the stratified squamous epithelium? Where can these epithelia are found in the human body? The simple squamous epitheliu

Main means by which autotrophic beings obtain energy, What is the main mean...

What is the main means by which autotrophic beings obtain energy? The major means by which autotrophs obtain energy is photosynthesis (There are also chemosynthetic autotrophs)

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd