Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

What is hemoglobin f, What is hemoglobin F? Why does the fetus need a diffe...

What is hemoglobin F? Why does the fetus need a different hemoglobin? Hemoglobin F is the hemoglobin found in the mammalian fetus and hemoglobin A is the normal hemoglobin. Hem

Function of noradrenaline in consciousness, Q. Function of Noradrenaline in...

Q. Function of Noradrenaline in consciousness? Increased level of noradrenalin is implicated in wakefulness. Locus coeruleus noradrenergic neurons decrease their rate of firing

Illustrate hypertrophic cardiomyopathy?, Q. Illustrate Hypertrophic cardiom...

Q. Illustrate Hypertrophic cardiomyopathy? It is a genetic disorder due to mutations in the gene that encodes for β-Cardiac myosin heavy chain (Localised to chromosome 14). It

Types of asexual reproduction, TYPES OF ASEXUAL REPRODUCTION ...

TYPES OF ASEXUAL REPRODUCTION 1 . Binar y fission - Amoeba 2. Multipl e fission -

Methods to overcome incompatibility, Methods to Overcome Incompatibility ...

Methods to Overcome Incompatibility It has been possible to facilitate the germination of incompatible pollen by extracting pollen wall proteins from compatible pollen and su

What are zymogens, Zymogens, or proenzymes, are enzymes secreted in inactiv...

Zymogens, or proenzymes, are enzymes secreted in inactive form. Under certain conditions, a zymogen shifts to the active form of the enzyme. Zymogen secretions in general occur due

Gas exchange, what arethe organs of respirationin the lower form of animals...

what arethe organs of respirationin the lower form of animals?

Chicken infectious anemia (cia), C h ic k e n infectious anemia (CIA) ...

C h ic k e n infectious anemia (CIA) Chicken infectious anemia virus (CIAV), a member of genus Gyrovirus of the family Circoviridae, is the causative agent of chicken infe

Which is the type of nitrogen waste birds produce, Which is the type of nit...

Which is the type of nitrogen waste birds produce? Why does this feature, besides being an adaptation to the terrestrial environment, also mean an adaptation to flight? Birds a

What is phylum nematoda - roundworms, What is Phylum Nematoda - Roundworms?...

What is Phylum Nematoda - Roundworms? Nematodes are commonly known as the roundworms. They have a pseudocoelom type of body cavity, and they have a digestive tract that opens t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd