Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Explain three basic sexual life cycles studied in biology, What are the thr...

What are the three basic sexual life cycles studied in Biology? Which of them corresponds to metagenesis? Which of them is the human life cycle? Sexual reproduction may take pl

Pressure gradient, Pressure Gradient You know that air pressure is the ...

Pressure Gradient You know that air pressure is the weight of the atmosphere over a unit area of the earth's surface. The average air pressure at sea level is approximately 1 k

How can germs can be transmitted, How can germs can be transmitted Germ...

How can germs can be transmitted Germs can be transmitted many ways, including: Touching dirty hands; Changing dirty or contaminated cloths; Through contaminated water and f

Devonian, Devonian  is the period of geologic time from 410 - 360 million y...

Devonian  is the period of geologic time from 410 - 360 million years before the present. Life on land diversified, with amphibians appearing late in this period of time. Plants we

Are there living beings without cells, Q Are there living beings without ce...

Q Are there living beings without cells? Viruses are considered the only living beings that do not have cells. Viruses are constituted by genetic material RNA or DNA enwrapped

Myocardial energetics, The oxidation of substrates like free fatty acids (F...

The oxidation of substrates like free fatty acids (FFA), glucose, lactate and ketone bodies results in the energy of Adenosine triphosphate (ATP) and Creatine phosphate (CP). The s

Divisions and representing species of the gymnosperms, Q. What are the majo...

Q. What are the major divisions and representing species of the gymnosperms? This group of plants can be separated into conifers (pine, sequoia, cypress), that have flowers cal

What are mycotoxins and how are they harmful, Q. What are mycotoxins and Ho...

Q. What are mycotoxins and How are they harmful? • Mycotoxins are toxins (secondary metabolites) produced by filamentous fungi on food and feed that cause illness when ingested

Why is this area more vulnerable to damage than others, A small family was ...

A small family was traveling in the car when a minor accident happened. The children in the back seats were wearing lap belts, but still sustained numerous bruises about the abdome

Electrophoresis gel to load 60, Assume your tilapia fish muscle homogenate ...

Assume your tilapia fish muscle homogenate has a protein concentration of 5769 ?g/ml. You take 32.5 ?l of this fish homogenate, mix it with 12.5 ?l sample buffer and 5 ?l reducing

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd