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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
#question.give the classes of protozoa phylum in detail with examples .
Osler's nodes are small, tender subcutaneous nodules that develop in the pulp of the digits or occasionally more proximally in the fingers and persist for hours to several days. Th
notochotr is absent in the group ...........
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How many different proteins, each composed of 8 amino acids, can be constructed using the 20 different amino acids found in proteins?
Q. How are gases exchanged in sponges? The gas exchange in sponges happens by diffusion from the exterior to the cells that absorb molecular oxygen and liberate carbon dioxide.
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What are biotic factors? The Biotic factors are living beings (plants, microorganisms and animals) that are part of a given environment.
a) How do viruses enter plant body and spread to long distances within it? b) Mention any two ways by which viruses spread from single plant to another.
Class of Crustacea - Malacostraca Malacostraca involves most of the larger forms such as crabs, lobsters, shrimps etc. and constitute the majority of crustacean species. The c
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