Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Hearing equilibrium, EQUILIBRIU M - Cristae and maculae are concerned ...

EQUILIBRIU M - Cristae and maculae are concerned with equilibrium. 1 .       DYNAMIC EQUILIBRIUM - Cristare detect turning or rotational movement of head ( angular ac

What is the function of glucose-6-phosphatase, What is the function of gluc...

What is the function of glucose-6-phosphatase? a) catalyze removal of one phosphate group from glucose b) catalyze removal of six phosphate groups from glucose c) catalyze the remo

Poultry and duck diseases-marek''s disease, Marek's disease Marek's dis...

Marek's disease Marek's disease is a lymphoproliferative disease of chicken, quails, bantams and other free-flying birds. It is caused by the Gallid Herpesvirus 2 of subfamily

Prevalence of coronaru heart diseases, Q. Prevalence of coronaru heart dise...

Q. Prevalence of coronaru heart diseases? Incidence of obesity, diabetes and CHD is increasing in India in almost all age groups. At present, obesity, which is a major risk fa

What is firing rate of carotid artery baroreceptors, What is firing rate of...

What is firing rate of carotid artery baroreceptors At 1:00 AM, person X's blood pressure is equal to the blood pressure set point.  At 1:01 AM, there is a decrease in the firi

Define water - important nutrient, Define Water - Important Nutrient? M...

Define Water - Important Nutrient? Macronutrients, you know, are those nutrients which are required in large amounts by our body namely, carbohydrates, fats and proteins. We st

What do you mean by overgloves, Q. What do you mean by Overgloves? The ...

Q. What do you mean by Overgloves? The purpose of these gloves is to use time more efficiently and to protect the skin on the hands through minimizing the number of times that

Can you explain abdominal aortography, Q. Can you explain Abdominal Aortogr...

Q. Can you explain Abdominal Aortography? The abdominal aorta starts at the level of diaphragm (T12). Here too, prior to performing an abdominal aortogram, a sound knowledge of

Explain spray-drying method, Spray-drying method Spray-drying is the co...

Spray-drying method Spray-drying is the common drying method in the production of ISP. The primary physical form of ISP in commerce, is that of fine powders. Structured form

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd