Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Steps involved in using bacteria to produce human insulin, Outline the step...

Outline the steps involved in using bacteria to produce human insulin. The gene for insulin is 'cut' from the appropriate strand of DNA using restriction enzymes. Plasmids are

What are mycotoxins, Q. What are mycotoxins? How are these produced and w...

Q. What are mycotoxins? How are these produced and where are these found? Are these naturally-occurring or produced? What is their significance? First what are mycotoxins?

Into which classes are mollusc divided, Into which classes are mollusc divi...

Into which classes are mollusc divided? What are some representing beings of each class? The phylum Mollusca is separated into five major classes: pelecypods, or bivalves (Pele

Composition - culture medium, Composition - Culture Medium A standard ...

Composition - Culture Medium A standard plant tissue culture medium (Basal medium) contains all the essential macro elements (Carbon, hydrogen, oxygen nitrogen, phosphorus, su

Methods by which diseases are transmitted, There are several methods by whi...

There are several methods by which a disease-causing organism can be transferred from the reservoir to the host organism. Direct contact : Disease - causing organism may be tr

Hormones in metamorphosis of amphibia, Hormones in Metamorphosis of Amphibi...

Hormones in Metamorphosis of Amphibia In amphibians, the changes that take place during metamorphosis are brought about by hormonal secretions of the thyroid gland. The first

Determine the uses of iron - soil, Determine the uses of Iron - Soil Ir...

Determine the uses of Iron - Soil Iron is a constituent of cytochromes, haem and non-haem enzymes. It is also essential for chlorophyll formation though is not a part of it. It

Temperate rain forests - ecosystem, Temperate rain forests - Ecosystem ...

Temperate rain forests - Ecosystem The temperate rain Forests are colder than any other rain forest and exhibit a marked seasonality with regard to temperature and rainfall. R

Where is the gall bladder located, Where is the gall bladder located? T...

Where is the gall bladder located? The gall bladder is located in the Upper Right Quadrant (URQ) of the abdomen just below the liver. It keeps bile secreted by the liver. The d

Explain about the importance of vitamin e in human body, Explain about the ...

Explain about the Importance of Vitamin E in Human Body? Vitamin E is the generic term for tocopherols and tocopherols that have a Phenolic functional group on a chromane ring

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd