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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
Difference between unconditioned and conditioned reflex action- S.NO . 1. UNCONDITIONED It is inborn CONDITIONED
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Etiology Fevers can be caused due to 1. Internal (endogenous) factors: This could be caused within the body. Examples are antigen-antibody reactions, malignant cancer, graf
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In biology, a species is smallest and basic unit of classification. Each species is placed within a single genus. For example biological name of human being is homosapiens. Here ho
How do you prevent food borne infection? Prevention of Food borne infections: Avoid consumption of contaminated foods and water Eat properly cooked foods Wash
why is it necessary to grind food before the testng?
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