Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

What is difficult breathing, What is difficult breathing? Difficult Bre...

What is difficult breathing? Difficult Breathing: Tachypnea (respiratory rates consistently more than 451 min), is a characteristic manifestation of heart failure in newborns (

What is sanitation in food service establishments, Q. What is Sanitation in...

Q. What is Sanitation in food service establishments? We start our study of this topic by first defining what is sanitation? A three-word definition of food sanitation

Head stream of highland brook zone, Head stream of Highland brook zone ...

Head stream of Highland brook zone This is formed by a number of small streams, which originate from a marsh, a spring or a glacier. This is a small shallow zone with an irreg

Whta is restrictions enzymes, A restriction enzyme or restriction endonucle...

A restriction enzyme or restriction endonuclease is an enzyme which cuts DNA at particular recognition nucleotide sequences with Type II restriction enzymes cutting double-stranded

What will happen to resting membrane potential, What will happen to resting...

What will happen to resting membrane potential if potassium succinate were injected into the intracellular environment (cytoplasm) of a neuron?

Vitamins requirements for ulcerative colitis, Q. Vitamins requirements for ...

Q. Vitamins requirements for ulcerative colitis? Vitamins: Commercial multivitamin preparation should be administered orally especially the ones needed for the healing process

What is subphylum crustacea and subphylum uniramia, What is Subphylum Crust...

What is Subphylum Crustacea and Subphylum Uniramia? The Arthropoda are usually grouped into four subgroupings called subphyla (singular-subphylum). One of these four subphyla -

Explain the photosensitive detectors, Explain the Photosensitive Detectors?...

Explain the Photosensitive Detectors? A wide range of detectors varying in senstivity and cost are available. They contain a light sensitive surface that releases electrons in

Does the trend of the change in shape of the graph, Does the trend of the c...

Does the trend of the change in shape of the graph as temperature increases differ when a different gas is examined?

Gas transportation systems in animals, Q. Oxygen comes from the environment...

Q. Oxygen comes from the environment and carbon dioxide in the end returns to the environment. How do small animals solve the problem of taking away and bringing these molecules fr

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd