Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

Photosynthesis, how do i prove in a diagram that water is needed for photos...

how do i prove in a diagram that water is needed for photosynthesis

Evolution, Who is the founder of theory survival of the fittest ?

Who is the founder of theory survival of the fittest ?

Describe the process of crassulacean acid metabolism, Describe the process ...

Describe the process of Crassulacean acid metabolism. a) How is it advantageous to plants? b) Describe the major steps in Krebs cycle. Why is this cycle also called citric a

Vascular cambium, Vascular Cambium The vascular cambium usually, if no...

Vascular Cambium The vascular cambium usually, if not always, has a dual origin within the primary tissues; from provascular strands, and from the "ground" meristem tissues be

Spoilage of poultry and poultry products, Q. Explain Spoilage of Poultry an...

Q. Explain Spoilage of Poultry and Poultry Products? Poultry meat is the muscle tissue of chicken, ducks, turkey etc. The reference to poultry meat generally is the 'dressed ch

Explain soybean protein, Explain soybean protein The need for the devel...

Explain soybean protein The need for the development of soybean protein concentrates stemmed primarily from two considerations: to enhance protein concentration and to improve

Hyaluronic acid, H Y ALURONI C ACID It is formed by alternating u...

H Y ALURONI C ACID It is formed by alternating unit of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid acts as animal cement between adjacent animal cells

Show major arthropod classes, Q. How are the three major arthropod classes ...

Q. How are the three major arthropod classes characterized according to the presence of antennae? Crustaceans have two pairs of antennae insects have one pair arachnids don't h

Of what subunits are ribosomes are made, Q. Of what subunits are ribosomes ...

Q. Of what subunits are ribosomes are made? Ribosomes are made of two subunits the small subunit and the large subunit. These subunits are made of proteins and ribosomic RNA (r

What are proteins and why they are important for us, What are Proteins and ...

What are Proteins and Why they are important for us? We just read that proteins are essential for maintaining and sustaining life. What are proteins or what constitutes protein

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd