Define voriconazole, Biology

Assignment Help:

Define Voriconazole

It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus  (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune)  and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.

 


Related Discussions:- Define voriconazole

What is the primary structure of a protein, What is the primary structure o...

What is the primary structure of a protein? What is the importance of the primary structure? Ans) The primary protein structure is the linear sequence of amino acids that produc

Draw decanol, Draw decanol, plamitic acid (C16:0 fatty acid) and the result...

Draw decanol, plamitic acid (C16:0 fatty acid) and the resulting wax ester generated by a dehydration reaction between both molecules.

What is ventilation, What is ventilation   A.  An increase in the hydro...

What is ventilation   A.  An increase in the hydrogen ion concentration in the interstitial spaces of the  brain stem leads to an increase in the duration of the respiratory cy

Define some features of penicillium, Define some features of Penicillium? ...

Define some features of Penicillium? The identifying features of Penicillium are: 1. Mycelium consists of colourless, septate and branched hyphae, some of which grow inside

How many cellular nuclei does the pollen tube of angiosperms, Q. How many c...

Q. How many cellular nuclei does the pollen tube of angiosperms have? What is ploidy of each of these nuclei? The pollen tube explicitly the mature male gametophyte of angiospe

Explain briefly pinocytosis , Unlike the phagocytosis, that is a regul...

Unlike the phagocytosis, that is a regulated form of endocytosis carried out by a small number of cell category, pinocytosis is a constitutive process which happens continuously in

Explain virus envelope, Virus envelope is known as: 1.  Capsid 2.  Vi...

Virus envelope is known as: 1.  Capsid 2.  Virion 3.  Nucleoprotein 4.  Core Capsid

Endosperm with lateral haustoria, Endosperm with Lateral Haustoria In...

Endosperm with Lateral Haustoria In Monochoria, in which the endosperm development is of helobial type, the haustorium is neither chalazal nor micropylar but lateral. The cha

Can a chemical reaction the free energy change to mol, In a chemical reacti...

In a chemical reaction the free energy change (/\Go') is -40 jk/mol and the entropy factor T/\S is 15 kj/mol. the enthalpy change /\H for the reaction is a. 25 kj/mol b.-25 k

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd