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Define Voriconazole
It is metabolized in the liver by CYP2C19, CYP2C9 and CYP3A4. CYP2C19 is genetically variant (about 3% to 5% of Caucasians and African-Americans and about 15% of Asians do not express it) and patients deficient in this enzyme may be exposed to higher concentrations of the drug. Voriconazole is contraindicated in patients taking rifampin, rifabutin, ergot alkaloids, long-acting barbitu- rates, carbamazepine, pimozide, quinidine, efavirenz (Sustiva), ritonavir (400 mg q12h) or sirolimus (Rapamune). Clinical monitoring or dose adjustment is required in patients taking warfarin (Coumadin, and others), sulfonylureas, statins, benzodiazepines, vinca alkaloids, nevirapine(Viramune) and HIV protease inhibitors other than indinavir. Omeprazole (Prilosec, and others), cyclosporine and tacrolimus require dose reductions when given with voriconazole. Patients taking phenytoin require enhanced doses of voriconazole and more frequent monitoring for phenytoin toxicity.
How are glycosidic bonds formed? The anomeric hydroxyl group and a hydroxyl group of another sugar or some other compound can join together, splitting out water to form a glyco
Q. What and how many are the pulmonary veins? The pulmonary veins are part of the pulmonary circulation they are vessels that carry oxygen-rich (arterial) blood from the lungs
Define the Importance of Zinc in Humans? Zinc deficiency in humans was reported by A.S. Prasad among people consuming mostly breads and very little animal protein in Middle Eas
Describe the terms diffusion, osmosis and filtration. Explain why each process is important for the human body.
Single chromosome of a pair is known as homologue.In Homologous pair two identical chromosomes are there. Each one chromosome in a Homologous pair is known as Homologue.
Bud grafting A 'T' shaped incision is made on the bark of the stock. A bark is removed on either side of vertical cut. A single bud scion with a little wood is placed
What are the cell types that form the phloem? What are the main features of those cells? The major cells that form the phloem are the sieve elements and the companion cells. Th
THYROID GLAND - It develops from the endoderm of the embryo. Th e thyroid gland is the largest endocrine gland located anterior to the thyroid cartilage of the larynx
Explain Some Functions of Riboflavin? Protective role: Riboflavin protects the octodermal tissues and prevents lesions of the skin, eye and nervous system. Riboflavin amelior
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