Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Why the enzymatic action is highly specific, Why can it be said that the en...

Why can it be said that the enzymatic action is highly specific? The enzymatic action is highly specific because only exact substrates of one enzyme bind to the activation cent

What is the salivary digestive enzyme, Q. What is the salivary digestive en...

Q. What is the salivary digestive enzyme? Which type of food does it digest and into which smaller molecules does it transform the food? The salivary hydrolase is known as sali

Define the carbohydrate and fat required for elderly, Define the Carbohydra...

Define the Carbohydrate and Fat required for elderly? Carbohydrate: It is usually recommended that approximately 55en% (percent of  energy) be provided from carbohydrate food

Fibre requirements for ulcerative colitis, Q. Fibre requirements for ulcera...

Q. Fibre requirements for ulcerative colitis? Fibre: Eliminating roughage seems to have a better effect on preventing relapses of the disease. A low residue diet may be given d

Nutritional requirements of fats and oils during pregnancy, Define Nutritio...

Define Nutritional Requirements of Fats and Oils during Pregnancy and Lactation? ICMR (1990) recommends that linoleic acid requirements should be raised to 4.5 en% during pregn

Give the introduction to evaluation of patient clinical, Give the introduct...

Give the introduction to evaluation of patient clinical examination ? A careful physical examinations is a very important for assessing the cardiovascular system and after prov

What is the usual biological function of connective tissues, Q. What is the...

Q. What is the usual biological function of the connective tissues? How is this function associated to the main features of its cells? The usual function of the connective tiss

Explain about spring model, Q. Explain about Spring Model ? The spring ...

Q. Explain about Spring Model ? The spring model depicts elasticity. A force is applied in terms of load onto the spring as illustrated in the figure 8.6. When the force is app

What progeny are expected in the f1, Cut wings (ct) is an X chromosome (sex...

Cut wings (ct) is an X chromosome (sex linked) recessive mutant of D melanogaster. Antennaless (al) is an autosomal recessive mutant. A cut, antennaless (homozygous) female is mate

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd