Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Define surgery, Define Surgery? Surgery ! Does the word itself not crea...

Define Surgery? Surgery ! Does the word itself not create a feeling of anxiety and bring our thoughts towards a debilitating state of health which would be accompanied by pain,

Define regents for determination of inorganic phosphorus, Define Regents fo...

Define Regents for Determination of Inorganic Phosphorus? 1. Trichloroacetic acid (10%) - Dissolve 100 g of high grade crystalline acid in distilled water and dilute to 1 Litre

Is phenoxyethanol harmful?, Phenoxyethanol is dangerous and can be absorbed...

Phenoxyethanol is dangerous and can be absorbed through the skin - official sites for toxicity data, though, show little toxicity in man and some toxicity (irritation) with high do

Wellness & fittness, what is the population for percentage of people being ...

what is the population for percentage of people being overweight

Which type of genetic disease can be identified, Which type of genetic dise...

Which type of genetic disease can be identified from the visual analysis of the number of chromosomes present in a karyotype? The counting and identification of chromosomes in

What are the luria''s methods and theories, What are the Luria's methods an...

What are the Luria's methods and theories Adhering to our theory that the Luria Nebraska bears little resemblance to Luria's methods and theories, there seems little point in i

Precautions for detection of number of bacteria in milk, Explain the Precau...

Explain the Precautions for Detection of Number of Bacteria in Milk? 1. Make a thin film of milk on the slide. 2. Do not over stain with methylene blue.  If over staining ha

Explain the four initial stages of the embryonic development, What are the ...

What are the four initial stages of the embryonic development? The four initial parts of the embryonic development are the morula stage, the blastula stage, the gastrula stage

Which type of ecological interaction is competition, Q. What is competition...

Q. What is competition? Which type of ecological interaction is competition? The Competition is the ecological interaction in which the individuals explore the similar ecologic

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd