Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

What are cd4 lymphocytes, What are CD4 lymphocytes? What is the relationshi...

What are CD4 lymphocytes? What is the relationship between these cells and HIV? How does HIV replicate? CD4 lymphocytes are T helper lymphocytes that there in their plasma memb

How do dioxins enter the human diet, Normal 0 false false f...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Explain the requirements of special stains, Explain the requirements of Spe...

Explain the requirements of Special Stains? Special stains are required to make spores clearly visible. Different techniques like negative staining, dorner staining method, sch

Define mineral trioxide aggregate - root end filling, Define Mineral Trioxi...

Define Mineral Trioxide Aggregate - Materials for Root End Filling Widely used Favorable biocompatibility Superior sealing qualities when compared to S-EBA and am

Lipoproteins, LIPOPROTEINS They are complex biomolecules formed of -...

LIPOPROTEINS They are complex biomolecules formed of - T riglycerides, Phospholipids, Cholesterol and Proteins. Lipoproteins are of four types - Chylomicrons

What is the difference between dna and rna, Q. Concerning their biological ...

Q. Concerning their biological function what is the difference between DNA and RNA? DNA is the source of information for RNA production (transcription) and thus for protein syn

Explain the surgical management for obesity, Explain the Surgical Managemen...

Explain the Surgical Management for Obesity? Surgical procedures are generally restricted for the morbidly obese persons. If an individual has a BMI of 40 or higher, or a BMI o

Name the important inorganic molecular for living being, What are the most ...

What are the most significant inorganic molecular substances for living beings? The most significant inorganic substances for living beings are mineral salts, water, carbon dio

Health promotion for the general population, Q. Health Promotion for the Ge...

Q. Health Promotion for the General Population? Targeted to have a healthy, risk free population and involves development of an effective communication strategy to modify indiv

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd