Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Define the dietary requirements of phosphorus, Define the Dietary Requireme...

Define the Dietary Requirements of phosphorus? We read in the previous section that the requirements of phosphorus are closely linked with those of calcium. The phosphorus req

Characteristics of river systems, Characteristics of River Systems Th...

Characteristics of River Systems The basic function of the rivers is to convey surplus rain water from land to sea. Annually the rivers carry fresh water, equivalent to 25 cm

Respiratory gases -respiration, Respiratory Gases -Respiration Physio...

Respiratory Gases -Respiration Physiologically the most important gases are oxygen, carbon dioxide and nitrogen. Molecular oxygen comprises 21% of the atmosphere; carbon diox

What is implant success, Implant success 1) An individual, unattached i...

Implant success 1) An individual, unattached implant is immobile when tested clinically. 2) A radiograph that does not demonstrate any evidence of perimplant radiolucency.

Population, Population You must be familiar with the term 'population'. I...

Population You must be familiar with the term 'population'. It is one of the most talked about issues of this century. It is feared that the rapid growth of the world population

Measurement of light intensity, Measurement of Light Intensity How do w...

Measurement of Light Intensity How do we measure the intensity of a source of light falling on a surface? You know that light spreads out uniformly in all directions from a sou

How many are the known amino acids, How many are the known amino acids that...

How many are the known amino acids that form proteins in living beings? There are twenty dissimilar known amino acids that form proteins related to the genetic code of the livi

Nitrate uptake, Nitrate Uptake Nitrate must enter the cells before und...

Nitrate Uptake Nitrate must enter the cells before undergoing assimilatory reduction by the joint action of nitrate reductase and nitrite reductase. Cells accumulate NO - 3

How is the concentration of drugs in human plasma defined, Some drugs bind ...

Some drugs bind extensively to plasma proteins (Warfarin binds 99%) while others have virtually no binding. Extraction depends on the type of drug - there are dissimilar standar

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd