Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

What is the meaning of prohaptor, What is the meaning of Prohaptor? The...

What is the meaning of Prohaptor? The specialized attachment sucker which surrounds the mouth in monogenean flukes. It comrpise adhesive structures which help attach the animal

Define sterol regulatory element binding proteins (srebps), Define Sterol R...

Define Sterol Regulatory Element Binding Proteins (SREBPS)? These belong to a general family of transcription factors. They are synthesized as membrane embedded proteins in res

Ethylene - plant growth substances, Ethylene - Plant Growth Substances ...

Ethylene - Plant Growth Substances This hydrocarbon C 2 H 2 is a gas and is unbelievably a small and simple molecule to be accepted as a hormone. Ethylene is not produced by

Explain the reproductive system, Explain the Reproductive System? The h...

Explain the Reproductive System? The human reproductive system produces not only reproductive organs and gametes, but also sex hormones, which have far-reaching effects on huma

Define prevention of vitamin a deficiency, Define Prevention of vitamin A d...

Define Prevention of vitamin A deficiency? Since dietary inadequacy is the major cause for micronutrient deficiencies, the most rational approach to prevent these deficiencies

Enzyme, Starch is a large molecule consisting of between 300 to 500 glucose...

Starch is a large molecule consisting of between 300 to 500 glucose molecules joined together.  A glucose molecule is only very small, consisting of 24 atoms.  Cellophane is simila

Illustrate the interphase, Q. Is the cell division happening during the ent...

Q. Is the cell division happening during the entire cell cycle? What is the interphase? Cell division properly occurs throughout the mitotic phase of the cell cycle. During int

Differences of transposable elements in e. coli, Discuss the similarities a...

Discuss the similarities and differences of transposable elements in E. coli, yeast, plants, and Drosophila.

Explain the physiologic mechanism of osseointegration, Q. Explain the Physi...

Q. Explain the Physiologic mechanism of osseointegration It has been suggested that the physiologic mechanism for maintaining osseous integration is a sustained evolution in re

In how many form glycogen synthase exists, Glycogen  synthase exists  in t...

Glycogen  synthase exists  in two forms:   the phosphorylated form designated  as  'D' form is the  inactive one and  the dephoshorylated form designated as  'I'  form is the activ

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd