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Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.
Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.
In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.
Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.
Explain Sterilization The physical process of killing microorganisms, including pathogenic and the bacteria, vegetative forms and other spores on or in an inanimate object o
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If I take a drug that induced the synthesis of CYP 2E1 in my system, would that raise or lower my blood alcohol level after I drink a beer or wine (compared to if I hadn''t taken t
Concerning the number of hosts how are parasites classified? Parasites that need only one host are known as monoxenous parasites. Parasites that need more than one host for th
Circulation of nutrients in the coastal zone Circulation of nutrients from the sea bottom to the upper surface, occurs in the coastal regions by two processes Upwelling
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Cardiac Prophylactic antibiotics can decrease the incidence of infection after cardiac surgery, and intraoperative redosing has been associated with adecreased risk of postoper
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Microevolution is: the change in allele frequency in a population. Cannot occur if genetic equilibrium is reached. Results in the formation of a new species. Is influenced by mutat
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