Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Parathyroid gland, PARATHYRIOD GLANDS - They develop from the endode...

PARATHYRIOD GLANDS - They develop from the endoderm of the embryo. The parathyroid glands consist of four separate glands located on the posterior surface of the lobes of

Deficiency diseases-predisposing factors, Predisposing factors The inc...

Predisposing factors The incidence of metabolic diseases in cows and buffaloes increases as the milk production increases and the herd size becomes larger. The highest inciden

Show takhtajans system of classification, Q. Show Takhtajans System of Clas...

Q. Show Takhtajans System of Classification? Another important phytogenetic system was proposed by Takhtajan, the famous Russian Palaeobotanist working at Komarov Botanical Ins

What is pre-requisites of counselling, Q. What is Pre-requisites of counsel...

Q. What is Pre-requisites of counselling? Pre-requisites of counselling are: 1. Facilities for counselling to be available for the patient near home or working place. 2.

Types of earthquake, Earthquakes Can Be classified into different categorie...

Earthquakes Can Be classified into different categories on the basis of region where it  occurs and the geological make-up of that region as : (i)     Tectonic earthquake: most

Of what importance are lactic acid fermentation to the cell, Of what import...

Of what importance are lactic acid fermentation and alcoholic fermentation to the cells that use these pathways? These pathways regenerate NAD, which the cells can use to keep

Type of disease identified chromosomes present in karyotype, Which type of ...

Which type of genetic disease can be identified from the visual analysis of the number of chromosomes present in a karyotype? The counting and the identification of chromosomes

Fission - asexual reproduction, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Respiration, different types of animals and their respiratory organ

different types of animals and their respiratory organ

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd