Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Explain the functionality of central nervous system, Explain the functional...

Explain the functionality of Central Nervous System ? The central nervous system is the center of the nervous system, receiving impulses from, and sending impulses to, the per

Role of wound epidermis and apical epidermal cap, Role of Wound Epidermis a...

Role of Wound Epidermis and Apical Epidermal Cap Earlier described that amputation, the stump epidermal cells at the wound edge migrate over and quickly cover the wound to fro

Ecosystem degradation and wildlife, Ecosystem Degradation and Wildlife ...

Ecosystem Degradation and Wildlife Man is an animal with ecological requirements just like any other animal. It constantly needs a source of energy and.minera1 nutrients for i

Explain flucytosine, Explain Flucytosine Flucytosine (Ancobon) - Potent...

Explain Flucytosine Flucytosine (Ancobon) - Potentially lethal, dose-related bone mar- row toxicity, colitis and rapid development of resistance when used alone limit the use o

Chronic exposure of cadmium, Q. Chronic exposure of Cadmium? An increa...

Q. Chronic exposure of Cadmium? An increase in the soil cadmium content due to soil pollution by industrial wastes, burning of coal, fossil fuels, sewage sludge, medical and

Enzyme synthesis, Enzyme Synthesis Nitrate assimilating system in gene...

Enzyme Synthesis Nitrate assimilating system in general is known to show increase in nitrate uptake system and nitrate reductase system in the presence of nitrate. In other wo

How are fruits formed, How are fruits formed? The fecundation in angios...

How are fruits formed? The fecundation in angiosperms triggers the release of hormones that act upon the ovaries. The ovary wall then makes into a fruit that having the seeds.

What is triacylglycerols, A triglyceride TG, TAG, triacylglycerol or triacy...

A triglyceride TG, TAG, triacylglycerol or triacylglyceride is an ester derivative from glycerol and three fatty acids. There are various triglycerides: depending on the oil source

Invertebrate, classification of invertebrate

classification of invertebrate

Define criteria for assessment of pyridoxine status, Define Criteria for As...

Define Criteria for Assessment of Pyridoxine Status? Vitamin B 6 status is most appropriately evaluated by using a combination of indicators,  namely plasma PLP concentration,

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd