Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

How natural colourants produced, Natural Colors Used In Foods Natural c...

Natural Colors Used In Foods Natural colourants produced for use in an analogous way to the coal-tar dyes are crude extracts of pigments, which are basically unstable. The appa

Differ from our current use of retroviruses, In what way may we be able to ...

In what way may we be able to take advantage of retrotransposons in human gene therapy? How would this differ from our current use of retroviruses?

Breathing and exchanges of gases , What happens to respiratory system in a ...

What happens to respiratory system in a man going up a hill?

Crayfish, the appendages of arthropods; a. may serve as walking legs, b. ma...

the appendages of arthropods; a. may serve as walking legs, b. may be modified into atennae, c. may be modified into large pincers, or d. all of the above

Procedures for diagnosis - electron microscopy, Direct demonstration of the...

Direct demonstration of the causative agent by electron microscopy (EM): Where facilities for electron microscopy are available and a viral disease is suspected, presence o

How do viruses enter plant body, a) How do viruses enter plant body and spr...

a) How do viruses enter plant body and spread to long distances within it? b) Mention any two ways by which viruses spread from single plant to another.

What is the difference between phenotype and genotype, What is genotype? Wh...

What is genotype? What is the difference between phenotype and genotype? The Genotype is the genes, DNA nucleotide sequences contained in the chromosomes of an individual, whic

Explain methodology required for osazone test, Explain Methodology Required...

Explain Methodology Required for Osazone Test? Take about 250-300 mg of phenylhydrazine mixture in the 3 clean labelled 15 ml dry test tubes. Add 5 ml of the glucose, fructose

Define types of root canal perforations according to size, Define Types of ...

Define Types of Root Canal Perforations According to size According to size: Small perforation: ( smaller than #20 endodontic instrument ) mechanical damage to tissue is

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd