Define the Insulin resistance - Obesity?

Insulin resistance is a condition in which your body cells cannot utilize insulin efficiently although sufficient amounts are secreted by the pancreas. Obesity is a contributing factor towards insulin resistance. Because sufficient insulin is being produced but the body cells are not able to use it, the blood insulin levels become high (hyperinsulinemia). This affects the utilization of glucose leading to high fasting blood sugar levels and abnormal glucose tolerance. In addition, levels of plasma glucagon (a hormone produced by pancreas having an effect opposite to that of insulin), free fatty acids and uric acid also are found to be elevated in obese individuals. All these altered biochemical parameters get back to normal as weight loss is affected.