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Define Streptomycin
Streptomycin causes ototoxicity (usually vestibular disturbance) and, less frequently, renal toxicity. Amikacin and kanamycin commonly cause tinnitus and high frequency hearing loss. These drugs and capreomycin can also cause nephro- and vestibular toxicity. Cycloserine can cause psychiatric symptoms and seizures. Ethionamide has been associated with gastrointestinal, hepatic and thyroid toxicity. A delayed-release granular formulation of aminosalicylic acid (PAS, Paser) is better tolerated than older formulations. Fluoroquinolones are usually well-tolerated, but can cause gastrointestinal and CNS disturbances.
Achondroplasia is an autosomal dominant disorder associated with a gene on chromosome 4. Sickle cell anemia is due to a gene on chromosome 11. A man and a woman with achondroplasia
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