Define role of lipids in controlling gene expression, Biology

Assignment Help:

Define role of Lipids in Controlling Gene Expression?

In the lipogenic pathway, the genes that encode the enzymes of the fatty acid synthase complex are co-ordinately expressed. Whether increased or decreased, all enzymes are synthesized to the same extent so that the pathway can function efficiently.Studies of the transcription and translation of all of the constituent components of this multifunctional complex have revealed that the fatty acid synthase is represented by a single gene that encodes seven gene products, the seven enzyme components of the fatty acid synthase complex. This enzyme complex is regulated by nutrients at the levels of both transcription and translation. Arachidonic acid, a fatly acid with 20 carbons and four double bonds, suppresses gene transcription. It is likely that the mechanism is one that involves a fatty acid binding protein that in turn binds to DNA as trans-acting element.

S14, a protein that seems to be important in the regulation of mRNA transcription of not only fatty acid synthase but also a number of carbohydrate metabolic enzymes, also, is suppressed by long-chain polyunsaturated fatty acids. The S14 gene has a Carbohydrate- responsive element as well. When diets rich in sugar are consumed, S14 mRNA increases, as do the mRNAs for glucokinase, glucose-6-phosphate dehydrogenase; 6-phosphogluconate dehydrogenase, and malice enzyme. In each of these instances, nutrients (glucose, fatty acids) are actively involved as parts of transcription regulatory elements. 


Related Discussions:- Define role of lipids in controlling gene expression

Evolution, related words for reproductive isolation.

related words for reproductive isolation.

Sastry, he heartbeat begins with the depolarization of the

he heartbeat begins with the depolarization of the

Cytology of endosperm, Cytology of Endosperm Normally the young endos...

Cytology of Endosperm Normally the young endosperm is triploid as it is formed by the fusion of three haploid nuclei (male gamete + upper polar nucleus + lower polar nucleus)

Heart, What is the immediate effects of exercise on the functions of the he...

What is the immediate effects of exercise on the functions of the heart?

Zoonotic diseases-viral haemorrhagic fevers (vhf), Viral haemorrhagic fever...

Viral haemorrhagic fevers (VHF) Viral haemorrhagic fevers (VHF) are caused by a diverse group of viruses belong to the families Arenaviridae, Bunyaviridae, Filoviridae and Fla

Explain physical properties of an oil, Explain Physical properties of an oi...

Explain Physical properties of an oil Physical properties of an oil or fat are of critical importance in determining its functional characteristics or use in food products. One

Explain the recommended dietary allowances - nutrition, Explain the Recomme...

Explain the Recommended Dietary Allowances - Nutrition? RDA: The RDA is the average daily dietary intake that is sufficient to meet the nutrient requirement of nearly all healt

Defence mechanisms of the host, Defence mechanisms of the host The hea...

Defence mechanisms of the host The healthy animal is protected from pathogenic organisms present in the environment by virtue of the effective immune mechanism present from bi

Substances that facilitate to compose the plasma membrane, Q. What are the ...

Q. What are the chemical substances that facilitate to compose the plasma membrane? The major constituents of the plasma membrane are phospholipids, proteins and carbohydrates.

Explain the process of metastasis, Explain the process of metastasis. Defin...

Explain the process of metastasis. Define anti-angiogenic drugs and relate the role of medical imaging, if any, in anti-angiogenic drug therapy. State how you envision your particu

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd