Define role in growth and cellular differentiation, Biology

Assignment Help:

Define Role in growth and cellular Differentiation?

The growth and differentiation of epithelial cells throughout the body are especially affected by vitamin A deficiency.  In addition, goblet cell numbers we reduced in epithelial tissues and as a consequence, mucous secretions diminish. Cells lining protective tissue surfaces fail to regenerate and differentiate; hence they flatten and accumulate keratin.  Classical symptoms of xerosis (drying or non-wet ability) and desquamation of  dead surface cells as seen in ocular tissue (i.e. xerophthalmia) are the external  evidence of the changes also occurring to various degrees in internal epithelial  tissues. Current understanding of the mechanism of vitamin A action within cells outside the visual cycle is that cellular functions are mediated through specific nuclear receptors. Binding with specific isomers of retinoic acid (i.e.all Tran- and 9-cis-retinoic acid) activates these receptors. Activated receptors bind to DNA response elements located upstream of specific genes to regulate the level of expression of those genes. These retinoid-activated genes regulate the synthesis of a large number of proteins vital to maintaining normal physiologic functions. There may, however be other mechanisms of action that are as yet undiscovered.

 


Related Discussions:- Define role in growth and cellular differentiation

What are pericardium - pleura and peritoneum, Q. What are pericardium, pleu...

Q. What are pericardium, pleura and peritoneum? Pleura are the membrane that covers the inner wall and the lungs of the chest pericardium are the membrane that covers the heart

The exine layer, The Exine Layer It consists of two layers, inner (nex...

The Exine Layer It consists of two layers, inner (nexine) which is continuous and an outer (sexine) the sculptured one. The outer layer has ornamentations comprising rod-like

What is the possible dna sequence, Insulin was the first protein to be sequ...

Insulin was the first protein to be sequenced biochemically. Assuming that there were no introns involved in the process, what are the possible DNA sequences that produced the last

What do you mean by bleeding index, Q. What do you mean by Bleeding Index? ...

Q. What do you mean by Bleeding Index? This factor is applicable at this stage to evaluate the health of one stage implants in which the transmucosal component allows the forma

What is subxiphoid short axis sweep, Q. What is Subxiphoid Short Axis Sweep...

Q. What is Subxiphoid Short Axis Sweep? To obtain the subxiphoid short axis view transducer should be rotated by 90 degree clockwise, fi-om the previous position so that p

Rapport - building, Rapport-Building Here the Counsellor tries to esta...

Rapport-Building Here the Counsellor tries to establish a rapport and gain the client's trust. Let us see how we make friend? When we meet someone we take time to react, we ob

What happens when the cell membrane ruptures, Explain what happens when the...

Explain what happens when the cell membrane or plasma membrane ruptures or breaks down? Ans) When cell membrane ruptures Ions leek out and unless repaired in time the cell will

Krebs cycle, Krebs Cycle The acetyl  group  of acetyl   co A  is now co...

Krebs Cycle The acetyl  group  of acetyl   co A  is now completey  degraded  stepwise  into  carbon  and hydrogen atoms  in the mitochondria  by a cyclic  sequence of  eight ma

Digestive system of animals, Q. Why is the digestive system of these animal...

Q. Why is the digestive system of these animals called incomplete? Incomplete digestive system is in that which the digestive cavity has only one opening.

EMBRYOLOGY.., WHAT IS RECAPITULATION THEORY OF EMBRYOLOGY?AND WHAT IS EMBRY...

WHAT IS RECAPITULATION THEORY OF EMBRYOLOGY?AND WHAT IS EMBRYOLOGY

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd