Define mobilization of bone calcium and phosphorous, Biology

Assignment Help:

Define Mobilization of bone calcium and phosphorous?

It is now firmly established that vitamin D3 is metabloized first in the liver to 25-hydroxyvitamin D (25 OH- D) (calcicliol) and subsequently in the kidneys to I. 25 dihydroxycholecalciferol  or 1.25 (OH)2 D (calcitriol to produce a biological active hormone. The functions of vitamin D are mediated by this vital vitamin D hormone by a homeostatic mechanism which involves the hormone acting on the intestines kidney and bone to increase serum calcium and phosphorus levels. 1.25 (OH)2D stimulates intestinal absorption of calcium and  phosphate and mobilized calcium and phosphate by stimulating bone resorption. The functions serve the common purpose of rstnring blood levels of calcium and phosphate to normal when concentrations of the two ions are low. This helps to achieve a normal blood calcium concentration and maintenance of calcium homeostasis.

2241_Mobilization of bone calcium and phosphorous.png

In calcium homeostasis, 1, 25-(OH) D works in conjunction with pa athyroid hormone (PTH) to produce its beneficial effects on the plasma levels of ionized calcium and phosphate. The physiologic loop starts with the calcium receptor of the parathyroid gland. When the level of ionized calcium in plasma falls, PTH is secreted by the parathyroid gland and stimulates the tightly regulated renal enzyme 25-OH-D-I-α-hydroxylnse to make more 1, 25-(OI-I)2D from the' large circulating  ,pool of 25-OH-D. The resulting increase in 1, 25-(OH)2D (with the rise in PTH)  causes an increase in calcium transport within the intestine, bone and kidney. All these events raise plasma calcium levels back to normal, which in turn is sensed by the calcium receptor of the parathyroid gland. The further secretion of PTH is turned off not only by the feedback action of calcium, but also by a short feedback loop involving 1, 25-(OH)2D directly suppressing PTH synthesis in the parathyroid  gland.


Related Discussions:- Define mobilization of bone calcium and phosphorous

What do you understand by pericardium, Q. What do you understand by Pericar...

Q. What do you understand by Pericardium? Pericardium is the covering sac of the heart. The pericardium prevents acute cardiac chamber dilatation. Acute pericarditis, pericardi

Explain about the autodispensor, Explain about the Autodispensor? This ...

Explain about the Autodispensor? This is used to transfer accurate quantities of liquids that are difficult to pipette like concentrated acids, alkalis, etc. You will also use

Dietary management of children with diarrhoea, Q. Dietary Management of Chi...

Q. Dietary Management of Children with Diarrhoea? Diarrhoeas are more common in children and malnutrition often leads to the elicitation of this symptom as undernourished are m

Unicellular organisms, How was it proved in the case of Amoeba that the key...

How was it proved in the case of Amoeba that the key to the life of a cell is Nucleus?

Blastomycosis, Blastomycosis Blastomyces dermatidis is a dimorphic fung...

Blastomycosis Blastomyces dermatidis is a dimorphic fungus existing as a mold in the soil (saprophytic stage) and as a yeast in tissues (parasitic stage). It causes systemic fu

A brief history of heart surgery, A brief history of heart surgery : The d...

A brief history of heart surgery : The dawn of Paediatric cardiac surgery was on August 26, 1938 when Robert, Gross, at the boston Children's Hospital, ligated ductus arteriosus

Define maxillofacial prosthodontics, Q. Define Maxillofacial Prosthodontics...

Q. Define Maxillofacial Prosthodontics? Dental implants are now been increasingly used for Maxillofacial Prosthodontics. Maxillofacial Prosthodontics involves the prosthetic re

Surface water sources and charactersitics, Most of the surface water origin...

Most of the surface water originates directly from precipitation in the form of rainfall or snow. Ground water from springs also contributes to the flow of most of the streams. The

Why immune response involves the activities of proteins, The immune respons...

The immune response involves the activities of proteins, cells, and the lymphatic system.

Raw material for industry - impacts on biodiversity, Raw Material for Indus...

Raw Material for Industry - impacts on biodiversity The industry, producing goods and services, relies and impacts on biodiversity directly. Much of the raw material that goes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd