Define mobilization of bone calcium and phosphorous, Biology

Assignment Help:

Define Mobilization of bone calcium and phosphorous?

It is now firmly established that vitamin D3 is metabloized first in the liver to 25-hydroxyvitamin D (25 OH- D) (calcicliol) and subsequently in the kidneys to I. 25 dihydroxycholecalciferol  or 1.25 (OH)2 D (calcitriol to produce a biological active hormone. The functions of vitamin D are mediated by this vital vitamin D hormone by a homeostatic mechanism which involves the hormone acting on the intestines kidney and bone to increase serum calcium and phosphorus levels. 1.25 (OH)2D stimulates intestinal absorption of calcium and  phosphate and mobilized calcium and phosphate by stimulating bone resorption. The functions serve the common purpose of rstnring blood levels of calcium and phosphate to normal when concentrations of the two ions are low. This helps to achieve a normal blood calcium concentration and maintenance of calcium homeostasis.

2241_Mobilization of bone calcium and phosphorous.png

In calcium homeostasis, 1, 25-(OH) D works in conjunction with pa athyroid hormone (PTH) to produce its beneficial effects on the plasma levels of ionized calcium and phosphate. The physiologic loop starts with the calcium receptor of the parathyroid gland. When the level of ionized calcium in plasma falls, PTH is secreted by the parathyroid gland and stimulates the tightly regulated renal enzyme 25-OH-D-I-α-hydroxylnse to make more 1, 25-(OI-I)2D from the' large circulating  ,pool of 25-OH-D. The resulting increase in 1, 25-(OH)2D (with the rise in PTH)  causes an increase in calcium transport within the intestine, bone and kidney. All these events raise plasma calcium levels back to normal, which in turn is sensed by the calcium receptor of the parathyroid gland. The further secretion of PTH is turned off not only by the feedback action of calcium, but also by a short feedback loop involving 1, 25-(OH)2D directly suppressing PTH synthesis in the parathyroid  gland.


Related Discussions:- Define mobilization of bone calcium and phosphorous

Is fecundation in mammals internal or external, Is fecundation in mammals i...

Is fecundation in mammals internal or external? Fecundation in mammals is internal, with copulation. In the contemporary world human technology is able to endorse artificial e

Define role of nutrients in controlling gene expression, Define Role of Nut...

Define Role of Nutrients in Controlling Gene Expression? The role of several nutrients in controlling gene expression, as mentioned earlier, is in infancy, but with advancing b

Bacteria, wine turns sour beause of the action of which bacteria? aerobic o...

wine turns sour beause of the action of which bacteria? aerobic or anerobic?

Explain the working of skeletal muscle, Explain the working of Skeletal Mus...

Explain the working of Skeletal Muscle? Skeletal muscle is under voluntary control and is responsible for voluntary movements of body parts. Skeletal muscle is also called stri

State the term - molybdenum, State the term - Molybdenum   Molybdenum i...

State the term - Molybdenum   Molybdenum is intimately related to nitrogen metabolism of plants. It is part of the nitrate reductase system which helps to utilise nitrate for n

How drugs increase food intake, How Drugs Increase Food Intake? You mus...

How Drugs Increase Food Intake? You must understand that drugs may also increase food intake. This is because they can: Stimulate appetite : This is a common side effect

Insulation by fur and feathers, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

What is the mitotic apparatus, Normal 0 false false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

The osmolarity of the rbcs and plasma after equilibration, Ed Rivers, a 3rd...

Ed Rivers, a 3rd year medical student, was alone in the hospital ER one night. It was unusually quiet that night, and the resident was getting some much needed sleep. A patient, Mr

Determine the functions of organ during pregnancy, Determine the Functions ...

Determine the Functions of Organ during pregnancy? Dramatic changes occur in renal functions to eliminate the nitrogenous and other waste products of maternal and foetal metabo

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd