Define mechanism for provide protection against colon cancer, Biology

Assignment Help:

Define Mechanisms for Provide protection against colon cancer?

Several plausable mechanisms have been formulated by which fibre may provide protection against colon cancer. These include:

1. Fibre that increases stool bulk results in the dilution of carcinogens. Fibre also decreases transit time thereby reducing the interactions of carcinogens with colonic mucosal cells.

2. Fibre binds potential carcinogens.

3. High bile acid concentrations are associated with increased risk of colon cancer. Fibres adsorb bile acids, thereby reducing the risk.

4. Fibre by providing fermentable substrate to colonic microflora alters species and number of microorganisms which may inhibit proliferation of tumor cells or conversion of procarcinogen to carcinogens.

5. Fermentation to SCFAs, reduces the pH, which in turn reduces synthesis of secondary bile acids. These bile acids have been shown to promote tumors.

6. Butyrate has been shown to have an effect on chromatin structure and thus could slow the proliferation and differentiation of cancer cells. Butyrate induces apoptosis (disintegration of cells).

7. Lignin may act as a free radical scavenger, thus reducing the risk of cancer.


Related Discussions:- Define mechanism for provide protection against colon cancer

How did darwin reach the principle of natural selection, How did Darwin rea...

How did Darwin reach the principle of natural selection from the observation of differences among individuals of the same species? The Darwin recognized that in a same species

Plant breeding, #questitypes of plant breeding on..

#questitypes of plant breeding on..

Blood plasma - circulation, Blood Plasma - Circulation Centrifugation...

Blood Plasma - Circulation Centrifugation of blood results in its separation into two portions - a packed mass of cells which constitute around 45 per cent of the volume of t

Haustorial behavior of embryo sac, Haustorial Behavior of Embryo Sac ...

Haustorial Behavior of Embryo Sac There are instances in which the entire embryo sac may grow beyond the ovular tissue. The central cell may also form multicellular projectio

Determine the term clade, Determine the term Clade? In cladistic taxono...

Determine the term Clade? In cladistic taxonomy, how groups of animals are related to each other. It includes the ancestral group and all of the other groups, or lineages, of a

What is bigunnides, Q. What is Bigunnides? Bigunnides: They are atni d...

Q. What is Bigunnides? Bigunnides: They are atni diabetic drugs which do not affect the output of insulin. These are preferred to sulphony lureas because they do not cause we

Morphological differences between monocot and dicot plants, Q. What are the...

Q. What are the major morphological differences between monocot plants and dicot plants? The main separation criteria between monocots and dicots are: number of cotyledons (see

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd