Define ligases, Science

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Ligases (synthetases)

These enzymes (code EC 6) catalyze the linkage of two molecules coupled with the hydrolytic breakdown of a pyrophosphate bond  in ATP or an analogous compound. The  bonds  formed  are  often  high  energy bonds.  The  second  figure  in  the  code number  indicates the bond  formed, e.g. C-O  (6.1), C-S  (6.2) etc. Examples include peptide synthase, aminoacyl-tRNA synthetase, DNA  ligase and RNA  ligase.

 


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