Define Historical example for Dynamical Network?

John Tyson constructed a nonlinear differential equation model representing the majority of the network of biochemical pathways occurring within yeast cells (Tyson et al. 2001). Every node in the network represents a particular enzyme or reagent; the concentration-dependent rates of reactions that generate and break down products are the links. Experimental data ascertains the structure of the network--the connection pattern and strengths of the links. The model suitably assumes the response of the system to novel perturbations such as removing a link-biologically, making a knockout mutant for a specific biochemical pathway. The model highlights critical reactions (network connections) that were not previously thought to be important. Such a theoretical approach is the only practical way to understand the emergent properties of such a network that cannot be tested empirically without an exhaustive series of experiments that grow exponentially with the size of the network.