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Define endocytosis of GLUT4 Transporters
Person X is a healthy human who has volunteered to take experimental drug Y. Person X has a normal dinner at 6 PM on April 1 and then does not eat or drink for 12 hours. There is no glucose in X's urine at 9 PM on April 1. At 5 PM on April 2, X takes a dose of Y. The action of drug Y occurs within 10 minutes and lasts for 12 hours. Person X has a normal dinner at 6 PM on April 2 and then does not eat or drink for 12 hours.
Which of the following is true?
A. If drug Y blocks all the transport of sodium and glucose via sodium-glucose co-transporters located in the luminal membranes of proximal tubule epithelial cells, then at 9 PM on April 2 there will be glucose in X's urine.
B. If drug Y blocks endocytosis of GLUT4 Transporters in all fat and muscle cells, then at 9 PM on April 2 there will be glucose in X's urine.
C. If drug Y causes the closing of all the ATP-sensitive potassium channels in the beta-islet cells of the pancreas, then at 9 PM on April 2 there will be glucose in X's urine.
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