Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Define Biosynthesis and Secretion of Thyroid Hormones?
Histologically, the functional cells of the thyroid gland are arranged in follicles, which surround a central lumen containing a colloid in which the hormones are stored in the form of thyroglobulin. Thyroglobulin is a glycoprotein and is synthesized in the follicular cell as prothyroglobulin and the tyrosine units are iodinated in the intact protein. As you may have noticed in Figure, the iodide actively transported into the cells from extracellular fluid (ECF) is released from the thyroid cells into the colloid follicle where it is oxidized by thyroperoxiduse in the presence of hydrogen peroxide.
The oxidized iodine is then combined with the amino acid tyrosine in thyroglobulin to form mono and di-iodotyrosines (MITIDIT), which are again catalyzed by thyroperoxidase. These are then coupled to form triiodo to thyronine and tetraiodo- thyroxine. The iodinated thyroglobulin is absorbed back into the cells by a process known as pinocytosis. The iodinated thyroglobulin is hydrolyzed within the cells by the cellular proteolytic enzymes to release T4 and T3 into the blood circulation. Unutilized mono- and di-iodotyrosines are not released into the blood but axe conserved within the gland for further incorporation into thyroglobulin. In blood, these hormones bind to transport proteins mainly thyroxine-binding-protein and are distributed to the target cells in the peripheral tissues. All phases of biosynthesis and secretion of thyroid hormones are stimulated by thyroid-secretary hormone (TSH), which is secreted by anterior pituitary gland in response to low levels of thyroid hormones.
I recently rented Physiology, An Integrated Approach and I was looking online because I have to also get the A&P access code and realize I could have rented it too with my book. Is
DIFFERENCE S BETWEEN "A" AND "I" BANDS A-Ban d (Anisotropic band) I-Ban d (Isotropic band) 1. It
define cytoplasm
Protein structure is determined solely by a protein amino acid sequence. Should a genetically engineered protein in which the order of all amino acids is reversed therefore have th
What is the Definition of Polyphenols? Polyphenols are the compounds that contain an-ON group attached to the benzene ring. The main classes are: flavonoids, phenolic acids and
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
Q. Enumerate the advantages of implant supported prosthesis over a removable one Removable soft tissue-borne partial dentures have one of the lowest patient acceptance rates in
Risk Characterization Risk Characterization : Integration of hazard identification, hazard characterization and exposure assessment into an estimation of the adverse e
Explain Leaf Primordia ? In contrast to the root, which produces branches from meristematic tissue called the pericycle, shoots have areas of meristematic tissues called nodes
Why did it take 150 years for the cell theory to be developed after microscopes were invented? Information about cells could not be understood and organized into a central theo
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +1-415-670-9521
Phone: +1-415-670-9521
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd