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Adverse Effects
The most common adverse effects of itraconazole are dose-related nausea and abdominal discomfort. Rash and serious hepatic toxicity can happen. The drug can cause hypokalemia, edema and hyper-tension. Congestive heart failure has been reported with itraconazole and the drug should not be used in patients with ventricular dysfunction.
Thrombocytopenia and leukopenia have also been reported. The intra-venous formulation have cyclodextrin, which can accumulate in azotemic patients; its use is not recommended in patients with creatinine clearance <30 mL/min.
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