Define about the glutathione peroxidases - selenium, Biology

Assignment Help:

Define about the Glutathione peroxidases - Selenium?

The role of selenium in the cytosolic enzyme, glutathione peroxidase (GSHPx), was first illustrated in 1973. Four selenium dependent glutathione peroxidases have been identified and named as Glutathione peroxidases 1-4 (GSHPxs 1-4). During stress, infection, or tissue injury, selenoenzymes may protect against the damaging effects of hydrogen peroxide or oxygen-rich free radicals. This family of enzymes catalyzes the destruction of hydrogen peroxide or lipid hydroperoxides according to the following general reactions:

H2O2 + 2GSH → 2H2O + GSSG

ROOH + 2GSH → ROH + H2O + GSSG

Where, GSH is glutathione and GSSG is its oxidized form.

Thus, from the reaction above, it is evident that the main role of glutathione peroxidases is to reduce hydrogen .peroxide and free hydroperoxides in different cells and tissues by using glutathione (GSH) as the hydrogen donor. Thus, the reactive species of hydroperoxide free radicals are converted into innocuous molecules of water. GSHPx-l is present in virtually all cells, GSHPx-2 is localized in the gastrointestinal tract, and GSHPx-3 is present in plasma while GSHPx-4 is most abundant in testis but present in other tissues also. GSrn4plays a major role in protecting against lipid peroxidation as it is the only intracellular enzyme that can reduce fatty acid hydro peroxide, GSHPx-3 in plasma can also perform this role.


Related Discussions:- Define about the glutathione peroxidases - selenium

State about charles elton, What evidence did Charles Elton collect that sug...

What evidence did Charles Elton collect that suggested that fluctuations in hare and lynx populations were related? What other evidence shows that these fluctuations ma

How to indicate an av block, During the course of a physiology laboratory, ...

During the course of a physiology laboratory, a student finds that her PR interval is 0.24 second. Concerned, she takes her own ECG again an hour later and sees an area of the ECG

What is asymmetric carbon atom, Asymmetric carbon atom   : a carbon atom at...

Asymmetric carbon atom   : a carbon atom attached with four different groups or atoms.

Ascus, what is ascus ?

what is ascus ?

Describe the working of immune system, Q. What is the function of the immun...

Q. What is the function of the immune system? The immune system performs specific defense against agents the antigens that are harmful to the body or foreign. Exogenous anti

State the aim of neuropsychological assessment, State the aim of Neuropsych...

State the aim of Neuropsychological assessment Neuropsychological assessments aim at specifying in as much detail as possible the functional deficits that exists in a manner th

Tapeworm, life cycle of tapeworm in detail

life cycle of tapeworm in detail

What are the cell kinds that form the phloem, What are the cell kinds that ...

What are the cell kinds that form the phloem? What are the major features of those cells? The major cells that form the phloem are the sieve elements and the companion cells an

Plants of dry environment open their stomata only at night, Why do few plan...

Why do few plants adapted to a dry environment open their stomata only at night? Throughout the day in dry habitats the guard cells become the stomata close and flaccid; concur

Determine the axon of a nerve cell, In the axon of a nerve cell, A. the...

In the axon of a nerve cell, A. the voltage-dependent conductance of the voltage-gated potassium channel has a faster time course than the voltage-dependent conductance of the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd