Based on your reading of the article "The Inner Life of the Genome" which of the following is a wrong statement regarding the organization of chromosomes within the nucleus?

A. Within a given cell type individual chromosomes tend to remain within distinct regions of the nucleus and are not randomly positioned. 

B. The position of chromosomes and genes can vary during distinct developmental stages and  among healthy and disease ridden cells.

C. Lamin proteins interact physically with actively transcribed regions of chromosomes and participate  in the localization of these genes to the center of the nucleus. 

D. The location of a gene within the nucleus impacts the regulatory status of the gene itself - genes  near the periphery are inactive whereas those in the center are actively transcribed.