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The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.
In the time series plot and scatter graphs there were many outliers that were clearly visible. These have been removed to identify if they were influential or had high leverage and
Multi-hit model is the model for a toxic response which results from the random occurrence of one or the more fundamental biological events. A response is supposed to be induced o
A two-step distillation and mixing process is shown in the figure. The system operates at steady-state conditions and there are no chemical reactions. The known flow rates and comp
Quittingill effect is a problem which occurs most frequently in studies of the smoker cessation where smokers frequently quit smoking following the onset of the disease symptoms
The problem that the studies are not uniformly probable to be published in the scientific journals. There is evidence that the statistical significance is a main determining factor
Chain-binomial models : Models arising in mathematical theory of the quite infectious diseases, which postulate that at any stage in the epidemic there are a certain number of the
An approach to investigations designed to recognize a particular medical condition in the large population, usually by means of a blood test, which might result in the considerable
methods of measuring trend
A standard IQ test has a mean of 98 and a standard deviation of 16. We want to be 99% certain that we are within 8 IQ points of the true mean. Determine the sample size
Technically the multivariate analogue of the quasi-likelihood with the same feature that it leads to consistent inferences about the mean responses without needing specific supposi
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