Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Define kappa coefficient, Kappa coefficient : The chance corrected index of...

Kappa coefficient : The chance corrected index of the agreement between, for instance, judgements and diagnoses made by the two raters. Calculated as the ratio of the noticed exces

Probability., 5. Packages from a machine a normally distributed with a mean...

5. Packages from a machine a normally distributed with a mean 200g and its standard deviation 2grams. Find the probability that a package from the machine weighs a) Less than

Coplot, This is the powerful visualization tool for studying how the respon...

This is the powerful visualization tool for studying how the response relies on an explanatory variable given the values of other explanatory variables. The plot comprises of a num

Gllamm, Gllamm is a program which estimates the generalized linear latent ...

Gllamm is a program which estimates the generalized linear latent and mixed models by the maximum likelihood. The models which can be fitted include structural equation models mul

Queuing theory, 1) Let N1(t) and N2(t) be independent Poisson processes wit...

1) Let N1(t) and N2(t) be independent Poisson processes with rates, ?1 and ?2, respectively. Let N (t) = N1(t) + N2(t). a) What is the distribution of the time till the next epoch

Adjusted r-squared, R-squared is regarded as the coefficient of determinati...

R-squared is regarded as the coefficient of determination and is used to give the proportion of the fluctuation of the variance of one variable to another variable. R-squared also

Homework and Assignment assistance for RES610 Course, Interested in 10 hour...

Interested in 10 hour program with twice a week tutoring for 1 hour each. Need tutor to assist with answering the assignment questions for the next 5 weeks.

Explain median absolute deviation (mad), Median absolute deviation (MAD) : ...

Median absolute deviation (MAD) : It is the very robust estimator of the scale given by the following equation   or, in other words we can say that, the median of the absolute

Please answer this question, How large would the sample need to be if we ar...

How large would the sample need to be if we are to pick a 95% confidence level sample: (i) From a population of 70; (ii) From a population of 450; (iii) From a population of 1000;

Determine the probablity, Dr. Stallter has been teaching basic statistics f...

Dr. Stallter has been teaching basic statistics for many years. She knows that 80% of the students will complete the assigned problems. She has also determined that among those who

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd