Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Decision tree, The graphic representation of the alternatives in a decision...

The graphic representation of the alternatives in a decision making problem which summarizes all the possibilities foreseen by the decision maker. For instance, suppose we are give

Math, A statewide survey of 1,706 California adults’ residents include the ...

A statewide survey of 1,706 California adults’ residents include the following question: would you favor or oppose providing a path to citizenship for illegal immigrants in the U.S

Latent class analysis, Latent class analysis is a technique of assessing w...

Latent class analysis is a technique of assessing whether the set of observations including q categorical variables, in specific, binary variables, consists of the number of diffe

Empirical bayes method, The procedure in which the prior distribution is re...

The procedure in which the prior distribution is required in the application of Bayesian inference, it is determined from empirical evidence, namely same data for which the posteri

Multimodal distribution, what is pdf,mean & variance for multimodal distrib...

what is pdf,mean & variance for multimodal distribution?

Estimation, The process of providing the numerical value for the population...

The process of providing the numerical value for the population parameter on the basis of information gathered from a sample. If a single ?gure is computed for the unknown paramete

Statistical and Numerical methods using C ++, Write a c++ program to find t...

Write a c++ program to find the sum of 0.123 ? 10 3 and 0.456 ? 10 2 and write the result inthree significant digits.

Degenerate distributions, The special cases of the probability distribution...

The special cases of the probability distributions in which the random variable's distribution is concentrated at one point only. For instance, a discrete uniform distribution when

Projection pursuit, Projection pursuit is a procedure for attaning a low-d...

Projection pursuit is a procedure for attaning a low-dimensional (usually two-dimensional) representation of the multivariate data, which will be particularly useful in revealing

Behrens fisher problem, Behrens Fisher problem : The difficulty of testing ...

Behrens Fisher problem : The difficulty of testing for the equality of the means of the two normal distributions which do not have the equal variance. Various test statistics have

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd