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The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.
Cellular proliferation models : Models are used to describe the growth of the cell populations. One of the example is the deterministic model where N(t) is the number of cel
Locally weighted regression is the method of regression analysis in which the polynomials of degree one (linear) or two (quadratic) are used to approximate regression function in
Huffman code is used to compress data file, where the data is represented as a sequence of characters. Huffman's greedy algorithm uses a table giving how often each character occur
Population averaged models are the models for kind of clustered data in which the marginal expectation of response variable is the main focus of interest. An alternative approach
Quota sample is the sample in which the units are not selected at the random, but in terms of a particular number of units in each of a number of categories; for instance, 10 men
Interim analyses : An analysis made before the planned end of a clinical trial, typically with the aim of detecting the treatment differences at the early stage and thus preventing
Maximum likelihood estimation is an estimation procedure involving maximization of the likelihood or the log-likelihood with respect to the parameters. Such type of estimators is
Hill-climbing algorithm is an algorithm which is made in use in those techniques of cluster analysis which seek to find the partition of n individuals into g clusters by optimizin
Ordered alternative hypothesis is a hypothesis or assumption which speci?es an order for the set of parameters of interest as an alternative to the equality, rather than simply th
Codominance : The relationship between genotype at the locus and a phenotype to which it in?uences. If an individuals with heterozygote (such as, AB) genotype is phenotypically dif
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