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The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.
Isobologram is a diagram used to characterize the interactions among jointly administered drugs or the chemicals. The contour of the constant response (that is the isobole), which
Computer-assisted interviews : A method or technique of interviewing subjects in which the interviewer reads the question from the computer screen instead of the printed page, and
In the network shown below, the rst of the two numbers on each arc indicates the arc capacity and the second (in parentheses) of the two numbers indicates the current flow. Use t
Two-phase sampling is the sampling scheme including two distinct phases, in the first of which the information about the particular variables of interest is collected on all the m
Method of moments is the procedure for estimating the parameters in a model by equating sample moments to the population values. A famous early instance of the use of the proced
A study not involving the passing of time. All information is collected at the same time and subjects are contacted only once. Many surveys are of this type. The temporal sequence
Technically the multivariate analogue of the quasi-likelihood with the same feature that it leads to consistent inferences about the mean responses without needing specific supposi
Leaps-and-bounds algorithm is an algorithm which is used to ?nd the optimal solution in problems which might have a large number of possible solutions. Begins by dividing the poss
A vague concept which occurs all through statistics. Essentially the term means the number of independent units of the information in an easy relevant to the estimation of the para
Complier average causal effect (CACE): The treatment effect amid true compliers in the clinical trial. For the suitable response variable, the CACE is given by the difference in o
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