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The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.
Weighted least squares is the method of estimation in which the estimates arise from minimizing the weighted sum of squares of the differences between response variable and its pr
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Log-linear models is the models for count data in which the logarithm of expected value of a count variable is modelled as the linear function of parameters; the latter represent
Hurdle Model: The model for count data which postulates two processes, one generating the zeros in the data and one generating positive values. The binomial model decides the bina
Initial data analysis (IDA): The first phase in the examination of the data set which comprises number of informal steps including the following steps * checking the quality o
Laplace distribution : The probability distribution, f(x), given by the following formula Can be derived as the distribution of the difference of two independent random var
Remedian: The robust estimator of location which is computed by an iterative process. By assuming that the sample size n can be written as bk where b and k are the integers, the s
Isobologram is a diagram used to characterize the interactions among jointly administered drugs or the chemicals. The contour of the constant response (that is the isobole), which
The rapid development or growth of the disease in a community or region. Statistical thinking has made very much significant contributions to the understanding of such type of phen
Coefficient of concordance : The coef?cient is taken in use to assess the agreement among m raters ranking n individuals according to some of the speci?c characteristic. Which can
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