Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Barrett and marshall model for conception, Barrett and Marshall Model for c...

Barrett and Marshall Model for conception : A biologically reasonable model for the probability of conception in a particular menstrual cycle, which supposes that the batches of sp

Construct the de bruijn digraph, A directed graph is simple if each ordered...

A directed graph is simple if each ordered pair of vertices is the head and tail of at most one edge; one loop may be present at each vertex. For each n ≥ 1, prove or disprove the

Best subsets regression, In the time series plot and scatter graphs there w...

In the time series plot and scatter graphs there were many outliers that were clearly visible. These have been removed to identify if they were influential or had high leverage and

Ain why the simulated result doesn''t have to be exact as the, ain why the ...

ain why the simulated result doesn''t have to be exact as the theoretical calculation

Categorizing continuous variables, Categorizing continuous variables : A pr...

Categorizing continuous variables : A practice which involves the conversion of the continuous variables into the series of the categories, which is common in the field of medical

Explain Geographical information system (gis), Geographical information sys...

Geographical information system (gis): The software and hardware configurations through which the digital georeferences are processed and displayed. Used to recognize the geograph

Bayesian confidence interval, Bayesian confidence interval : An interval of...

Bayesian confidence interval : An interval of the posterior distribution which is so that the density of it at any point inside the interval is greater than that of the density at

Describe hello-goodbye effect., Hello-goodbye effect : The phenomenon initi...

Hello-goodbye effect : The phenomenon initially described in psychotherapy research, but one which might arise whenever a subject is assessed on two occasions, with some interventi

Gaussian markov random field, It is the multivariate normal random vector w...

It is the multivariate normal random vector which satisfies certain conditional independence suppositions. This can be viewed as a model framework which contains a wide range of st

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd