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The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.
The method or technique for producing the sequence of parameter estimates that, under the mild regularity conditions, converges to maximum likelihood estimator. Of particular signi
Maternal mortality : The maternal death is the death of a woman while pregnant, delivering a baby or within 42 days of the termination of pregnancy, from any reason related to or a
Glim is the software package specifically suited for fitting the generalized linear models (the acronym stands for the Generalized Linear Interactive Modelling), including the log
L'Abbe ´ plot is often used in the meta-analysis of the clinical trials where the result is the binary response of it. The event risk (number of events/number of the patients in a
Ascertainment bias : A feasible form of bias, particularly in the retrospective studies, which arises from the relationship between the exposure to the risk factor and the probabil
Demographic data: Age: continuous variable Gender: categorical variable with males coded 1, females coded 2. Relationship status: categorical variable 1 to 5. Rational
Geometric distribution: The probability distribution of the number of trials (N) before the first success in the sequence of Bernoulli trials. Specifically the distribution is can
Paired availability design is a design which can lessen selection bias in the situations where it is not possible to use random allocation of the subjects to treatments. The desig
The procedures used for determining how the quality of life is affected by the environment, in particular by factors such as air and solid wastes, water pollution, hazardous substa
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