Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Tests for heteroscedasticity, Lagrange Multiplier (LM) test The Null Hy...

Lagrange Multiplier (LM) test The Null Hypothesis - H0: There is no heteroscedasticity i.e. β 1 = 0 The Alternative Hypothesis - H1:  There is heteroscedasticity i.e. β 1

Cross-sectional study, A study not involving the passing of time. All infor...

A study not involving the passing of time. All information is collected at the same time and subjects are contacted only once. Many surveys are of this type. The temporal sequence

G, sfdgfdg

sfdgfdg

Please answer this question, How large would the sample need to be if we ar...

How large would the sample need to be if we are to pick a 95% confidence level sample: (i) From a population of 70; (ii) From a population of 450; (iii) From a population of 1000;

Method of moments, Method of moments   is the procedure for estimating the...

Method of moments   is the procedure for estimating the parameters in a model by equating sample moments to the population values. A famous early instance of the use of the proced

Collective risk models, Collective risk models : The models applied to insu...

Collective risk models : The models applied to insurance portfolios which do not create direct reference to the risk characteristics of individual members of the portfolio when des

Quota sample, Quota sample is the sample in which the units are not select...

Quota sample is the sample in which the units are not selected at the random, but in terms of a particular number of units in each of a number of categories; for instance, 10 men

Disease mapping, The method of displaying the geographical variability of t...

The method of displaying the geographical variability of the disease on maps using different colors, shading, etc. The logic is not new, but the arrival of computers and computer g

Statistical and Numerical methods using C ++, Write a c++ program to find t...

Write a c++ program to find the sum of 0.123 ? 10 3 and 0.456 ? 10 2 and write the result inthree significant digits.

Independent or Dependent variable, Whats the independent variable in the fo...

Whats the independent variable in the following sentence? -1) In a drug prevention program for boys and girls, will family-participation result in effective drug use reduction?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd