Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Expected frequencies, A term commonly encountered in the analysis of the co...

A term commonly encountered in the analysis of the contingency tables. Such type of frequencies are the estimates of the values to be expected under hypothesis of interest. In a tw

Decision tree analysis, Ask questioThe finance manager of ‘Softy’ baby soap...

Ask questioThe finance manager of ‘Softy’ baby soap manufacturing company being successful in the first two years of the company’s operations is considering setting up another plan

Explain information theory., Information theory: This is the branch of app...

Information theory: This is the branch of applied probability theory applicable to various communication and signal processing problems in the field of engineering and biology. In

Non parametric maximum likelihood (npml), Non parametric maximum likelihood...

Non parametric maximum likelihood (NPML) is a likelihood approach which does not need the specification of the full parametric family for the data. Usually, the non parametric max

Auto correlation, Auto correlation : The correlation of the internal observ...

Auto correlation : The correlation of the internal observations in the time series, generally expressed as a function of the time lag between the observations. It is also used for

Parks test, The Null Hypothesis - H0: β 1 = 0 i.e. there is homoscedastici...

The Null Hypothesis - H0: β 1 = 0 i.e. there is homoscedasticity errors and no heteroscedasticity exists The Alternative Hypothesis - H1: β 1 ≠ 0 i.e. there is no homoscedasti

Explain kleiner hartigan trees, Kleiner Hartigan trees is a technique for ...

Kleiner Hartigan trees is a technique for displaying the multivariate data graphically as the 'trees' in which the values of the variables are coded into length of the terminal br

Explain multiple comparison tests, Multiple comparison tests : Procedures f...

Multiple comparison tests : Procedures for detailed examination of the differences between a set of means, generally after a general hypothesis that they are all equal has been rej

Genomics, Genomics  is the study of the structure, function and the evoluti...

Genomics  is the study of the structure, function and the evolution of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequences which comprise the genome of living organisms

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd