Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Regression, what are tests for residual with nonconstant variance in regres...

what are tests for residual with nonconstant variance in regression diagnostic checking?

Explain Genstat, Genstat: The basic purpose piece of statistical software ...

Genstat: The basic purpose piece of statistical software for the management and the analysis of data. The package incorporates the wide variety of data handling events and a wi

Response feature analysis, Response feature analysis is the approach to th...

Response feature analysis is the approach to the analysis of longitudinal data including the calculation of the suitable summary measures from the set of repeated measures on each

Bartlett''s test for variances, Bartlett's test for variances : A test for ...

Bartlett's test for variances : A test for equality of the variances of the number (k)of the populations. The test statistic can be given as follows   where s square is an

Expected-utility maximizer, There are two periods. You observe that Jack co...

There are two periods. You observe that Jack consumes 100 apples in period t = 0, and 120 apples in period t = 1. That is, (c 0 ; c 1 ) = (100; 120) Suppose Jack has the util

Randomized encouragement trial, Randomized encouragement trial   is the cl...

Randomized encouragement trial   is the clinical trials in which the participants are encouraged to change their behaviour in a particular manner (or not, if they are allocated to

Computer-aided diagnosis, Computer-aided diagnosis : The computer programs ...

Computer-aided diagnosis : The computer programs which are designed to support clinical decision making. In common, such systems are based on the repeated application of the Bay

Draw histogram of income, The skewness is a measure of asymmetry and as it ...

The skewness is a measure of asymmetry and as it is positive at 4.29, it is greater than zero which reveals that the tail extends to the right indicating the distribution to be mor

Math, A statewide survey of 1,706 California adults’ residents include the ...

A statewide survey of 1,706 California adults’ residents include the following question: would you favor or oppose providing a path to citizenship for illegal immigrants in the U.S

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd