Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Free racials, Which of the following could potentially be a free radical? A...

Which of the following could potentially be a free radical? Answer oxygen (atomic number 8) helium (atomic number 2) neon (atomic number 10)

Role of a nurse in legal psychiatry, ROLE OF A NURSE IN LEGAL PSYCHIATRY: ...

ROLE OF A NURSE IN LEGAL PSYCHIATRY: 1)   Standard Care : The nurse must function at laid down standards and keep up with the standard of  care by  knowing the policies  & pro

What are the structures that form the external ear, What are the structures...

What are the structures that form the external ear? What is its function? The internal ear comprises the pinna, or auricle, and the auditory canal. Its function is to conduct t

#ti.., what would happen if there is no revolution?

what would happen if there is no revolution?

Transgenic animals, T ra n sge n i c animals There are various d...

T ra n sge n i c animals There are various definitions for the term transgenic animal . The transgenic animal is an animal in which there has been a deliberate modifica

Explain the flow phase of stress response, Explain the Flow Phase of Stress...

Explain the Flow Phase of Stress Response? This is a neuro-endocrine response to physiological stress following the ebb phase. This phase is characterized by: Normal or

Define nutritional requirements for young and older children, Define Nutrit...

Define Nutritional requirements for Young and Older Children? Young children need 3 en%, which would be easily met from 8-10 g of oil. However, more visible oil is needed to im

Enumerate the working of mri scanner, Enumerate the working of MRI scanner ...

Enumerate the working of MRI scanner The MRI scanner can be 'tuned' to detect the very subtle disturbances to the magnetic field induced by the different proportions of oxygen

Ventricular assist devices in circulatory assist devices, Ventricular Assis...

Ventricular Assist Devices :  These come handy when IABP has failed or when prolonged circulatory support is needed. Now Ieft ventricular (LVAD), right ventricular (RVAD) and bive

Virus, whats ur clear definition of virus

whats ur clear definition of virus

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd