Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Major groups into which the study of the plants is divided, Q. What are the...

Q. What are the four major groups into which the study of the plants is divided? In Botany the plant kingdom is divided into pteridophytes, bryophytes, angiosperms and gymnospe

What is binary fission in cell reproduction, What is Binary Fission in cell...

What is Binary Fission in cell reproduction? Cell division takes place in prokaryotic cells by binary fission, also called prokaryotic fission. In prokaryotes, DNA is contained

Show the inflammation triggered by bacterial infection, Q. Which type of de...

Q. Which type of defense cell do bacteria attract and cause to multiply during the inflammation process? What is the name given to the waste material produced by the inflammation t

Evolution, related words for reproductive isolation.

related words for reproductive isolation.

Freshwater biomes, Low levels of dissolved salts characterise the freshwate...

Low levels of dissolved salts characterise the freshwater biomes. The salt content of fresh water is about 0.005 percent. The freshwater biomes consist of inland bodies of standing

Experiment of stanley miller (1953) on the origin of life, What was the exp...

What was the experiment of Stanley Miller (1953) on the origin of life? In 1953 the Stanley Miller arranged an experimental apparatus that simulated the atmospheric conditions

Determine the biologic response, Determine the biologic response The bi...

Determine the biologic response The biologic response can include: i) Metabolic disturbance. ii) Inflammatory response iii) Immune response iv) Mutagenesis v) Ca

Phosphate group from an atp molecule, A molecule that acts by transferring ...

A molecule that acts by transferring a phosphate group from an ATP molecule to another molecule would be called: A) hydrolase. B) lipase. C) transferase. D) ligase. E) kinase.

Define the prevention of diseases - function of vitamin e, Define the Preve...

Define the Prevention of diseases - Function of Vitamin E? Because of its anti-oxidant function and its role in inhibiting cell proliferation of smooth muscles, vitamin E can b

What is class amphibia , What is Class Amphibia ? Class Amphibia take...

What is Class Amphibia ? Class Amphibia takes its name from the Greek words "amphi" and "bios." Amphi means "both sides," or "both types," and bios means "life." This name-bo

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd