Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Circulation, Circulation, Respiration and Excretion of Asteroidea Aste...

Circulation, Respiration and Excretion of Asteroidea Asteroids depend upon the circulation of coelomic fluid for the transport of gases and some nutrients. The blood vascular

What is single ventricle physiology, What is Single Ventricle Physiology ? ...

What is Single Ventricle Physiology ? In complete correction of a congenital cardiac condition, it is ideal to have two ventricle correction (Pulmonary and systemic ventricles

What are good pharmacovigilance process, Question 1: What are Good Phar...

Question 1: What are Good Pharmacovigilance Process and Good Post-Marketing Surveillance Process? How do they differ from each other? Define and illustrate briefly Good Post

Define dehydration reaction between both molecules, Some organisms contain ...

Some organisms contain enzymes that condense a fatty alcohol and a fatty acid to generate wax esters. Draw decanol, plamitic acid (C16:0 fatty acid) and the resulting wax ester gen

Types of neurons, TYPE S OF NEURONS - The neurons are classified on th...

TYPE S OF NEURONS - The neurons are classified on the basis of their structure and function. (A) On the basis of the structure, the neurons are of four types.

Congenital aortic stenosis-types of aortic stenosis, Congenital Aortic Sten...

Congenital Aortic Stenosis :  The valve may be unicuspid, bicuspid or tricuspid. Rarely it is a dome shaped diaphragm. Uni commissural aortic stenosis produces significant sy

Microbiology, general characteristics of cynobacteria

general characteristics of cynobacteria

Define reagents required and methodology for benedict test, Define reagents...

Define reagents required and methodology for Benedict Test? Reagents Required - Sugar solutions of glucose, fructose, galactose, maltose, lactiose, sucrose and starch.

Sequence for the beta actin gene, The sequence for the Beta Actin gene (ACT...

The sequence for the Beta Actin gene (ACTB) is given below. Which pair of primers (designed to amplify the entire sequence below) could be used to successfully produce the beta act

Explain the sub-culturing, Explain the Sub-Culturing? Microbiological s...

Explain the Sub-Culturing? Microbiological studies require microorganisms in pure form, i.e., a single type of microorganisms should be present in a culture. Maintenance of the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd