Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Vital dye staining, Vital Dye Staining In this type of method, a piec...

Vital Dye Staining In this type of method, a piece of agar or cellophane soaked in the solution of a vital dye (Neutral Red, Nile Blue Sulphate, and Bismarck Brown etc.) is a

What is a population, Q. What is a population? In the Biology a populat...

Q. What is a population? In the Biology a population is a set of individuals of the same species living in a given place and in a given time.

Thumb rule for dietary management, Q. Thumb rule for dietary management? ...

Q. Thumb rule for dietary management? The thumb rule for dietary management is to advice the patient to try to cut down or avoid:  Red meats. Organ meats such as br

Explain the use of trichomoniasis in pregnancy, Use of trichomoniasis in pr...

Use of trichomoniasis in pregnancy Trichomoniasis in pregnancy has been associated with adverse pregnancy outcomes (D Soper, Am J Obstet Gynecol 2004; 190:281). Metronidazole

The thumb and index finger with a dry-skin resistance, A person notices a m...

A person notices a mild shock if the current along a path through the thumb and index finger exceeds 84 µA. Compare the maximum possible voltage without shock across the thumb and

Cell biology, explain in detail the cell theory and it exceptions

explain in detail the cell theory and it exceptions

Explain about balanus, Explain Balanus The realised niche of Balanus ...

Explain Balanus The realised niche of Balanus is the same as its fundamental niche  Lower limits:   as for fundamental niche. Upper  limits: as for fundamental niche

Find the electric potential, (a) Find the electric potential, taking zero a...

(a) Find the electric potential, taking zero at infinity, at the upper right corner (the corner without a charge) of the rectangle in the figure. (Let y = 3.7 cm and x = 6.7 cm.)

Radioisotopes, Radioisotopes Radioisotopes are those forms of an elemen...

Radioisotopes Radioisotopes are those forms of an element which exhibit rzdioactivity and so can be used as markers or tracers. For this purpose, we first introduce the radiois

Explain dietetics, Explain Dietetics Dietetics  has been defined as  t...

Explain Dietetics Dietetics  has been defined as  the science and art of feeding individuals based  on the principles of  nutrition. It can also be  said  to  be  the "science

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd