Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Define cellulose, Cellulose Cellulose is found in plants as microfibr...

Cellulose Cellulose is found in plants as microfibrils (2-20 nm diameter and 100-40,000 nm long). These form the structurally strong framework in the cell walls. Cellulose is

Describes calcium metals, Which of the following terms best describes calci...

Which of the following terms best describes calcium metals? Check all that apply. Molecule, element, matter, and compound

Calculate the ph - microbial survival and growth, Calculate the pH - microb...

Calculate the pH - microbial survival and growth? Presence of microorganisms also depends on the pH of the medium. Most bacteria grow optimally near neutral pH (optimum 6.5 - 7

Carbohydrates requirements for ulcerative colitis, Q. Carbohydrates require...

Q. Carbohydrates requirements for ulcerative colitis? Carbohydrates: They form the easily absorbable source of energy. Bulk-producing vegetables are restricted so as to allow b

Explain about precautionary principle, Q. Explain about precautionary princ...

Q. Explain about precautionary principle? The ethical values of biodiversity highlights the intrinsic value of biodiversity for its own sake and it is independent of the varied

What is biodiversity, Q. What is biodiversity? The Biological diversity...

Q. What is biodiversity? The Biological diversity is the variety of species of living beings of an ecosystem. In the ecosystems which are more biodiverse, like tropical forests

Define the operations of a public nutritionist, Define the Operations of a ...

Define the Operations of a Public Nutritionist? A public nutritionist can perform the following: In the hospital-based set up, she is a part of the team delivering thera

Organic Evolution, I am studying the evolution of a giraffe. How do I find ...

I am studying the evolution of a giraffe. How do I find more information?

Protozoa, Characteristics Protozoa and examples

Characteristics Protozoa and examples

Levels of organization of matter - metazoa, Levels of organization of Matte...

Levels of organization of Matter- Metazoa The smallest structural units of all matter are subatomic particles, mainly electrons, protons and neutrons. The next larger units a

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd