Coronary prevention, Biology

Assignment Help:

a) The West of Scotland Coronary Prevention Study (WOSCOPS): The study randomized healthy men between the ages of 45 and 64 years with TC levels higher that 252 mg/dL and LDL cholesterol levels of 174 to 232 mg/dL to pravastatin (40mg/day) or to placebo for an average of 5 years and demonstrated a 31 per cent relative reduction in the incidence of nonfatal MI or CAD death.

b) The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS): AFCAPS/TexCAPS capitalized on the increased risk among healthy persons with low HDL levels (mean, 36mg/dL) and high TC levels (mean, 221 mg/dL). Therapy with the cholesterol-lowering drug lovastatin reduced by 36 per cent the risk for first acute major coronary events among healthy adults with average to mildly elevated cholesterol levels and low HDL levels.

c) The Heart Protection Study (HPS) (5) randomized 20,536 subjects to daily simvastatin (40mg) or placebo and to antioxidants or placebo (the antioxidant arm did not show any benefit or harm). The study focused on patients who were deemed high risk but not thought to merit treatment with statins based on the prevalent clinical practice. Increased risk was defined as presence of or history of Coronary Artery Disease, cerebovascular disease, peripheral vascular disease, diabetes mellitus, or treated hypertension in men younger than 65 years. Simvastatin therapy was associated with a 17 per cent relative reduction in the risk of death, driven primarily by a 17 per cent relative risk reduction in nonfatal MI, a 25 per cent relative reduction in the incidence of first stroke, 30 per cent reduction in coronary revascularisation, and 16 per cent reduction in noncoronary revascularization procedures were observed. Event reduction was similar across multiple subgroups and was largely uninfluenced by pretreatment lipoprotein values. Treating LDL levels less than 100mg/dL was also associated with a beneficial reduction in vascular events.


Related Discussions:- Coronary prevention

Chambers of heart, The ventricles are separated from each other by the inte...

The ventricles are separated from each other by the interventricular septum and the atria are separated from each other by the interatrial septum. The interior of the right atrium

Explain about the invert sugar, Explain about the Invert sugar? Invert ...

Explain about the Invert sugar? Invert sugar is sucrose, which can be hydrolysed to split the disaccharide into its component sugars, fructose and glucose. It is known as inver

Biology in ancient india, BIOLOGY IN ANCIENT INDIA - L A T E STONE ...

BIOLOGY IN ANCIENT INDIA - L A T E STONE AGE [10,000 - 20, 000 B.C) Man first cultivated wheat, barley, lentils & peas. In India rice was first cultivated at Meherga

Explain the five kingdom systems, The five kingdom systems To cope up w...

The five kingdom systems To cope up with above discussed problem a number of alternative classificatory schemes have been suggested with more than two kingdoms. The one which h

How are cnidarian characterized, Q. Cnidarian identity card. How are they c...

Q. Cnidarian identity card. How are they characterized according to instance of representing beings, basic morphology, kind of symmetry, germ layers and coelom, digestive system, r

Heparinisation, Heparinisation Blood when allowed to flow out from ...

Heparinisation Blood when allowed to flow out from body to the circuit tubings can get clotted. To prevent this, heparinisation is done. Patient is administered 3 mg

Explain about the duration of exercise for diabetics patient, Explain about...

Explain about the duration of exercise for diabetics patient After selecting an exercise, it is very important to know the vigorous nature, duration and timings of the exercise

Coelenterata, is cnidaria having both interacellular & extracellular digest...

is cnidaria having both interacellular & extracellular digestion?

What is nadp and nadph, What is NADP and NADPH? NADP is the abbreviatio...

What is NADP and NADPH? NADP is the abbreviation of the nicotinamide adenine dinucleotide phosphate cation, a hydrogen acceptor. NADPH is made when NADP binds to one hydrogen a

Criticism of lamarckism, point out the criticism of lamarckism in any six s...

point out the criticism of lamarckism in any six short points.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd