Columbian exchange had the greatest long-term impact, History

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Compare and contrast the impact of the Columbian Exchange on the Atlantic coast of North America and on the portion of western and central Africa affected by the slave trade. Discuss according to Mann's book1493 as your principal source but also considering geographical variables discussed in Guns, Germs and Steel and subsequent developments in the region. In which area has the Columbian Exchange had the greatest long-term impact?

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