Clinical trials, Advanced Statistics

Assignment Help:

Clinical trials: Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c research, namely that the new information is attained from the comparison of the alternative states. The three main components of a clinical trial are given below:

* Comparison of the group or set of patients given the treatment under the investigation with another group or set of the patients given either an older or the standard treatment, in one exists, or an 'inert treatment' commonly known as the placebo (or the control group).

Some trials might include more than two groups.

* A way of assigning patients to the treatment and control groups or sets.

* A measure of the outcome, that is a response variable.

One of the most significant aspects of the clinical trial is the question of how the patients should be allocated to the treatment and the control group. The objective in the allocation is that the treatment group and control group should be similar in all respects except treatment taken. As a result the clinical trial is more likely to give an unbiased estimate of the difference between the two treatments. The most suitable (perhaps only suitable) method of the allocation is randomization leading to randomized clinical trials, the gold standard for the treatment assessment.

 


Related Discussions:- Clinical trials

Residual calculation, Regression line drawn as y= c+ 1075x ,when x was2, an...

Regression line drawn as y= c+ 1075x ,when x was2, and y was 239,given that y intercept was 11. Calculate the residual ?

Probability, Modern hotels and certain establishments make use of an electr...

Modern hotels and certain establishments make use of an electronic door lock system. To open a door an electronic card is inserted into a slot. A green light indicates that the doo

Frailty, A term usually used for unobserved individual heterogeneity. Such ...

A term usually used for unobserved individual heterogeneity. Such variation is of main concern in the medical statistics particularly in the analysis of the survival times where ha

Decision Analysis, Build-Rite construction has received favorable publicity...

Build-Rite construction has received favorable publicity from guest appearances on a public TV home improvement program. Public TV programming decisions seem to be unpredictable, s

Rational –experiential inventory, Demographic data: Age: continuous vari...

Demographic data: Age: continuous variable Gender: categorical variable with males coded 1, females coded 2. Relationship status: categorical variable 1 to 5. Rational

Maximum likelihood estimation, Maximum likelihood estimation is an estimat...

Maximum likelihood estimation is an estimation procedure involving maximization of the likelihood or the log-likelihood with respect to the parameters. Such type of estimators is

Determine the maximum amount of the commodity, A manufacturing company has ...

A manufacturing company has two factories F 1 and F 2 producing a certain commodity that is required at three retail outlets M 1 , M 2 and M 3 . Once produced, the commodity is

Doubly multivariate data, This term is sometimes used for the data collecte...

This term is sometimes used for the data collected in those longitudinal studies in which more than the single response variable is recorded for each subject on each occasion. For

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd