Clinical trials, Advanced Statistics

Assignment Help:

Clinical trials: Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c research, namely that the new information is attained from the comparison of the alternative states. The three main components of a clinical trial are given below:

* Comparison of the group or set of patients given the treatment under the investigation with another group or set of the patients given either an older or the standard treatment, in one exists, or an 'inert treatment' commonly known as the placebo (or the control group).

Some trials might include more than two groups.

* A way of assigning patients to the treatment and control groups or sets.

* A measure of the outcome, that is a response variable.

One of the most significant aspects of the clinical trial is the question of how the patients should be allocated to the treatment and the control group. The objective in the allocation is that the treatment group and control group should be similar in all respects except treatment taken. As a result the clinical trial is more likely to give an unbiased estimate of the difference between the two treatments. The most suitable (perhaps only suitable) method of the allocation is randomization leading to randomized clinical trials, the gold standard for the treatment assessment.

 


Related Discussions:- Clinical trials

Describe law of likelihood, Law of likelihood : Within framework of the sta...

Law of likelihood : Within framework of the statistical model, a particular set of data supports one statistical hypothesis or assumption better than another if the likelihood of t

Computer-intensive methods, Computer-intensive methods : The statistical me...

Computer-intensive methods : The statistical methods which require almost identical computations on the data repeated number of times. The term computer intensive is, certainly, a

Explain perturbation theory, Perturbation theory : The theory useful in ass...

Perturbation theory : The theory useful in assessing how well a specific algorithm or the statistical model performs when the observations suffer less random changes. In very commo

Continual reassessment method, Continual reassessment method: An approach ...

Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic

Protocol, Protocol is the formal document outlining the proposed process f...

Protocol is the formal document outlining the proposed process for carrying out the clinical trial. The basic features of the document are to study the objectives, patient selecti

Calculate cutoff values and analyzing histograms, 1. You are interested in ...

1. You are interested in investigating if being above or below the median income (medloinc) impacts ACT means (act94) for schools. Complete the necessary steps to examine univariat

Unequal probability sampling, Unequal probability sampling is the sampling...

Unequal probability sampling is the sampling design in which the different sampling units in the population have different probabilities of being included in sample. The differing

Hosmer-lemeshow test, Hosmer-Lemeshow test is a goodness-of-fit test taken...

Hosmer-Lemeshow test is a goodness-of-fit test taken in use in logistic regression, particularly when there are regular covariates. Units are spitted into deciles based on predict

Describe nuisance parameter, Nuisance parameter : The parameter of the mode...

Nuisance parameter : The parameter of the model in which there is no scienti?c interest but whose values are generally required (but in usual are unknown) to make inferences about

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd