Clinical trials, Advanced Statistics

Assignment Help:

Clinical trials: Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c research, namely that the new information is attained from the comparison of the alternative states. The three main components of a clinical trial are given below:

* Comparison of the group or set of patients given the treatment under the investigation with another group or set of the patients given either an older or the standard treatment, in one exists, or an 'inert treatment' commonly known as the placebo (or the control group).

Some trials might include more than two groups.

* A way of assigning patients to the treatment and control groups or sets.

* A measure of the outcome, that is a response variable.

One of the most significant aspects of the clinical trial is the question of how the patients should be allocated to the treatment and the control group. The objective in the allocation is that the treatment group and control group should be similar in all respects except treatment taken. As a result the clinical trial is more likely to give an unbiased estimate of the difference between the two treatments. The most suitable (perhaps only suitable) method of the allocation is randomization leading to randomized clinical trials, the gold standard for the treatment assessment.

 


Related Discussions:- Clinical trials

Principal factor analysis, Principal factor analysis is the method of fact...

Principal factor analysis is the method of factor analysis which is basically equivalent to a principal components analysis performed on reduced covariance matrix attained by repl

Hypergeometric distribution, Hypergeometric distribution is t he probabili...

Hypergeometric distribution is t he probability distribution related with the sampling without replacement from the population of finite size. If the population comprises of r ele

Histogram, Histogram is the graphical representation of the set of observat...

Histogram is the graphical representation of the set of observations in which class frequencies are represented by the regions of rectangles centred on the class interval. If the f

Conjoint analysis, Conjoint analysis : The method used basically in market ...

Conjoint analysis : The method used basically in market research which is similar in many respects to the various dimensional scaling. The method attempts to assign values to the l

Operations Management, 1.Sam Lucarelli, owner of Lucarelli Products, is eva...

1.Sam Lucarelli, owner of Lucarelli Products, is evaluating whether to produce a new product line. After thinking through the production process and the costs of raw materials and

Change point problems, Change point problems : Problems with chronologicall...

Change point problems : Problems with chronologically ordered data collected over the period during which there is known to have been a change in the underlying data generation cou

Multi dimensional unfolding, Multi dimensional unfolding is the form of mu...

Multi dimensional unfolding is the form of multidimensional scaling applicable to both the rectangular proximity matrices where the rows and columns refer to the different sets of

Frequency distribution, The division of a sample of observations into sever...

The division of a sample of observations into several classes, together with the number of observations in each of them.  It acts as a useful summary of the main features of the da

Combine standard deviation, what is the combine standard deviation height f...

what is the combine standard deviation height from the follwing

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd