Clinical trials, Advanced Statistics

Assignment Help:

Clinical trials: Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c research, namely that the new information is attained from the comparison of the alternative states. The three main components of a clinical trial are given below:

* Comparison of the group or set of patients given the treatment under the investigation with another group or set of the patients given either an older or the standard treatment, in one exists, or an 'inert treatment' commonly known as the placebo (or the control group).

Some trials might include more than two groups.

* A way of assigning patients to the treatment and control groups or sets.

* A measure of the outcome, that is a response variable.

One of the most significant aspects of the clinical trial is the question of how the patients should be allocated to the treatment and the control group. The objective in the allocation is that the treatment group and control group should be similar in all respects except treatment taken. As a result the clinical trial is more likely to give an unbiased estimate of the difference between the two treatments. The most suitable (perhaps only suitable) method of the allocation is randomization leading to randomized clinical trials, the gold standard for the treatment assessment.

 


Related Discussions:- Clinical trials

Geographical analysis machine, Geographical analysis machine is the proced...

Geographical analysis machine is the procedure designed to detect the clusters of rare diseases in a particular area. Circles of fixed radii are created at each point of the squar

Quality-adjusted survival analysis, Quality-adjusted survival analysis is ...

Quality-adjusted survival analysis is a method for evaluating the effects of treatment on survival which allows the consideration of quality of life as well as the quantity of lif

Curse of dimensionality, The phrase first spoken by one of the witches in M...

The phrase first spoken by one of the witches in Macbeth. Now this is used to describe the exponential rise in the number of possible locations in the multivariate space as dimensi

Evaluate the maximum flow, In the network shown below, the rst of the two ...

In the network shown below, the rst of the two numbers on each arc indicates the arc capacity and the second (in parentheses) of the two numbers indicates the current  flow. Use t

Contour plot, Contour plot : A topographical map drawn from data comprising...

Contour plot : A topographical map drawn from data comprising observations on the three variables. One variable is represented on horizontal axis and the second variable is represe

Decision Analysis, Build-Rite construction has received favorable publicity...

Build-Rite construction has received favorable publicity from guest appearances on a public TV home improvement program. Public TV programming decisions seem to be unpredictable, s

Efficiency, This term applied in the context of comparing the different met...

This term applied in the context of comparing the different methods and techniques of estimating the same parameter; the estimate with the lowest variance being regarded as the mos

Explain post stratification adjustment, Post stratification adjustmen t: On...

Post stratification adjustmen t: One of the most often used population weighting adjustments used in the complex surveys, in which weights for the elements in a class are multiplie

Probability, Modern hotels and certain establishments make use of an electr...

Modern hotels and certain establishments make use of an electronic door lock system. To open a door an electronic card is inserted into a slot. A green light indicates that the doo

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd