Clinical trials, Advanced Statistics

Assignment Help:

Clinical trials: Medical experiments designed to assess which of two or more treatments is much more effective. It is based on one of the oldest philosophy of the scienti?c research, namely that the new information is attained from the comparison of the alternative states. The three main components of a clinical trial are given below:

* Comparison of the group or set of patients given the treatment under the investigation with another group or set of the patients given either an older or the standard treatment, in one exists, or an 'inert treatment' commonly known as the placebo (or the control group).

Some trials might include more than two groups.

* A way of assigning patients to the treatment and control groups or sets.

* A measure of the outcome, that is a response variable.

One of the most significant aspects of the clinical trial is the question of how the patients should be allocated to the treatment and the control group. The objective in the allocation is that the treatment group and control group should be similar in all respects except treatment taken. As a result the clinical trial is more likely to give an unbiased estimate of the difference between the two treatments. The most suitable (perhaps only suitable) method of the allocation is randomization leading to randomized clinical trials, the gold standard for the treatment assessment.

 


Related Discussions:- Clinical trials

Direct edacyclic graph, Formal graphical representation of the "causal diag...

Formal graphical representation of the "causal diagrams" or the "path diagrams" where the  relationships are directed but acyclic (that is no feedback relations allowed). Plays an

Statistics, cholscores Treatment income ($000) Patient ID low Income? ...

cholscores Treatment income ($000) Patient ID low Income? 0.6 Old 21.3 2 Yes 0.17 Old 27.2 13 Yes 0.69 New 27.1 16 Yes 1.09 Old 94.8

Non central distributions, Non central distributions is the series of prob...

Non central distributions is the series of probability distributions each of which is the adaptation of one of the standard sampling distributions like the chi-squared distributio

Generate a scatter plot, Suppose we estimate the following model: Passen...

Suppose we estimate the following model: Passengersi = 1 + 2Populationi + ui a) Generate a scatter plot with passengers on the vertical axis and population on the horizonta

Drug stability studies, The studies conducted in the pharmaceutical industr...

The studies conducted in the pharmaceutical industry to calculate the degradation of the new drug product or an old drug formulated or packaged in the new manner. The main study ob

Bartlett''s test for variances, Bartlett's test for variances : A test for ...

Bartlett's test for variances : A test for equality of the variances of the number (k)of the populations. The test statistic can be given as follows   where s square is an

Explain post stratification adjustment, Post stratification adjustmen t: On...

Post stratification adjustmen t: One of the most often used population weighting adjustments used in the complex surveys, in which weights for the elements in a class are multiplie

Case-cohort study, Case-cohort study : The research design in epidemiology ...

Case-cohort study : The research design in epidemiology which involves the sampling of controls at the outset of the study that is to be compared with the cases from the cohort. Th

Cluster analysis, Cluster analysis : A set of methods or techniques for con...

Cluster analysis : A set of methods or techniques for constructing a sensible and informative classi?cation of an initially unclassi?ed set of data, using variable values observed

Normality - reasons for screening data, Normality - Reasons for Screening...

Normality - Reasons for Screening Data Prior to analyzing multivariate normality, one should consider univariate normality Histogram, Normal Q-Qplot (values on x axis

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd