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The American Heart Association (AHA) has recommended the revised Jones Criteria as a guide for ARF diagnosis. The same have been approved by WHO study group for the diagnosis of initial attack of ARF (Table 1.1). The salient clinical features for the diagnosis of ARF are given in Fig. Revised Jones Criteria are (a) Major Criteria (b) Minor Criteria.
Table Revised Jones Criteria
Major Manifestations Minor Manifestations Carditis A) Clinical findings Polyarthritis - Arthralgia Erythema marginaum - Fever Subcutaneous nodules B) Laboratory findings Chorea - Leucocoytosis - Raised ESR - Raised CRP - Prolonged P-R Interval plus Supporting Evidence of Antecedent GAS Infection such as positive throat culture or rapid streptococcal antigen test. Elevated or rising ASO or other streptococcal antibodies titre.
What proportion of children with Down syndrome do you expect when women with Down syndrome have children with men who have 46 chromosomes justify your answer?
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