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CLEAVAGE -
Holoblastic & unequal. First plane is meridional. 2 blastomeres are formed. 1 megamere & another micromere.
2nd plane is also meridional but at 90° to first one.
It takes first in larger blastomere, so for short time 3 celled stage is formed followed by 4 celled stage of embryo.
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It is immune difficult mediated hypersensitivity. Typical manifestations contain rheumatoid arthritis, serum sickness, necrotizing etc.
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