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Chromosome jumping is the technique whereby one begins with a piece of DNA from one area of a chromosome, and obtains clones from nearby areas without cloning everything in between (as in chromosome walking). One round of jumping yields the new clones at the distances of several tens of kb away from the beginning point. In practice, this method is used when classical genetics proves that a known piece of DNA is located on the chromosome close to the gene you would like to clone (like a human disease gene). By cloning the fragments some distance away in both the directions from the known fragment, one might attain (1) fragments further from the required gene (which are discarded); (2) the fragments are even more closely linked to the required gene (in which case one goes for another round of jumping); or (3) fragments from within required gene - the optimal result.
Q. What do you understand by Hiatus Hernia? Several long/short term complications may arise due to GERD which may in turn increase the frequency or severity of this disease. On
Determine the various neurobehavioural characteristics Contemporary views of brain function tend to conceptualise localisation in interaction with a number of developmental and
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why would it be difficult to determine accurate values for the four variables in the Lotka-Volterra predator-prey model (a, rprey, m, b) for animals in the real world?
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Explain Adverse effects of Amprenavir The most common adverse effects have been nausea, vomiting (especially in combination with zidovudine), perioral paresthesias and rash (J
Which of the following activators is correctly paired with the glycolytic or gluconeogenic enzyme that is activates? -AMP: Fructose 1,6 Bis -Citrate: Fructose 1,6 Bis -Fru
Define Functions of selenium in humans? Until recently, the only known metabolic role of selenium in humans was as a component of glutathione peroxidase which along with vitami
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