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Among neonates, IE typically involves the tricuspid valve of structurally normal hearts and is associated with very high mortality rates. It is likely that many of these episodes arise as a consequence of infected intra venous and right heart catheters as well as cardiac surgery. The vast majority of children with IE occurring after the neonatal period have identifiable structural cardiac abnormalities. Rheumatic heart disease is the major predisposition for IE in developing countries. Congenital heart abnormalities, particularly those involving the aortic valve; ventricular septal defects; tetralogy of Fallot; and other complex structural anomalies associated with cyanosis (TGA, single ventricle) are found in remaining cases. Of children with IE on congenital defects, 50 per cent develop infection after cardiac surgery; in these children, infection frequently involves prosthetic valves, valved conduits, or synthetic patches. Mitral valve prolapse generally in association with a regurgitant murmur has been recognized to predispose to IE in children.
Endocarditis among neonates is caused primarily by S.aureus, coagulase-negative staphylococci, and group B streptococci. Occasionally infection is caused by gram- negative bacilli and candida species. Among older children, streptococci, the predominant cause account for at least 40 per cent of cases, and S. aureus occurring as a nosocomial or community acquired acute infection is the second most common cause of IE.
The clinical features and echocardiographic findings of IE in children are similar to those noted among adults with NVE or PVE, respectively. In contrast, IE among neonates is more cryptic; the clinical picture is dominated by bacteremia, and classical signs of IE are rare.
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The risk for IE among IV drug abusers, 2 to 5 per cent per patient- year, is estimated to be several fold greater than that of patients with rheumatic heart disease or prosthetic v
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Two major objectives must be achieved to treat IE effectively. The infecting micro-organism in the vegetation must be eradicated. Also, invasive, destructive intracardiac and foca
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