BONE MARROW TRANSPLANT -

1. It is transplanted to treat leukemia.
2. Here, graft itself causes immune rejection.
3. Before transplant, the recipient's bone marrow cells, including any abnormal cells are destroyed by irradiation.
4. This treatment fully eliminates the recipient's immune system, leaving little chance of graft rejection.
5. The lymphocytes of the donated marrow react against the recipient.
6. This graft versus host reaction can be minimized MHC molecules of the donor and recipient are very closely matched.