Artificial skin, Biology

Assignment Help:

Artificial Skin:

The skin generated in vitro is in fact the epidermis portion of skin only; when the epidermis is applied to the burnt part, this leads to the regeneration of dermis (remaining parts of skin) beneath. But improvements in the approach  have allowed the reconstitution of virtually complete skin (both epidermis and dermis), called as living skin equivalent (LSE); this technology uses a collagen matrix as a support for development of the tissue. The skin explants used for attaining artificial skin may be either obtained from the patient concerned or from the foreskin (loose skin from the tip of penis) of newborn. Skin cells of new-borns grow more strongly than adult skin; the use of a synthetic polymer called as PGA helps the newborn skin to develop with no scars. Artificial skin from newborn skin explants is used to wrap the wound until the patient's skin is cultured and artificial skin is gained for grafting.

The production of artificial skin is following   and this is particularly cell and not organ culture. The bulk (Ca 90%) of epidermis is constituted by cells that called keratinocytes which generated the dead cells (corneocytes) making up the outermost cornfield layers of skin. The keratinocytes are dissociated by treating the skin explants with trypsin. These cells are sophisticated in vessels the bottom of which is enclosed with irradiated 3T3 fibroblast cell line; this is because certain products from fibroblast cells facilitate the proliferation of keratinocytes. Keratinocytes develop to make colonies, which are again dissociated into single cells and cultured in the same manner. The process is repeated again and again till a confluent sheet of pure epithelium is completed; this sheet is detached from the culture vessels, cleaned and used for grafting. The explants for developing artificial skin for the graft might come from the patient himself to avoid rejection. A 3 cm2 skin explants may yield about 1.7 m2 artificial skin in 3-4 weeks representing a 5000-fold increase. In approximate 5 years after grafting of the artificial skin, all the essential components of skin are regenerated. Artificial skin grafts have been used to successfully repair several types of skin defects, including chronic skin ulcers.


Related Discussions:- Artificial skin

Eggs, What is the type of egg in which yolk is absent?

What is the type of egg in which yolk is absent?

Nutritional management in inflammatory bowel disease, Q. Nutritional Manage...

Q. Nutritional Management in Inflammatory Bowel Disease? Adequacy of nutritional needs and minimizing stress on the inflamed or narrowed segment of the bowel are the main princ

Metabolism of proteins, The major component of food is protein. The protein...

The major component of food is protein. The proteins ingested as part of our diet are not the same proteins required by the body, nor can large molecules be absorbed from the gut.

What is the heterotrophic hypothesis on the origin of life, What is the het...

What is the heterotrophic hypothesis on the origin of life? As per to the heterotrophic hypothesis the first living beings were very simple heterotrophic organisms that is not

Internal factor - factor controlling metamorphosis in insect, Internal Fact...

Internal Factor - Factors Controlling Metamorphosis in Insects Likewise to the amphibian metamorphosis, moulting and metamorphosis in insects has been found to be initiated in

What are energy allowance, Energy Allowance: Energy Allowance: The  p...

Energy Allowance: Energy Allowance: The  patient's requirement for  energy  varies with the physical activity and physiological condition. For instance, consider a person con

Effect of destruction of microbial barriers, Q. Effect of Destruction of Mi...

Q. Effect of Destruction of Microbial Barriers? Physical damage to the integument allows microbial invasion of the underlying nutrient-rich tissues and it is a common observati

Equipment and supplies -pre-requisite of nursing unit, Equipment and Suppli...

Equipment and Supplies: Nurses who are aware of location of equipment and supplies do give accurate delivery of patient care without delay and wastage of  time and energy for

Mechanism of enzyme action, Mechanism  of Enzyme Action  The action of...

Mechanism  of Enzyme Action  The action of enzymes is to lower  the activation energy  or threshold  of their substrates which. Therefore  become  activated and   react  with

Basic structure of heart, Basic Structure of Heart The heart is small...

Basic Structure of Heart The heart is small organ about the size of one's fist, located in the middle and slightly to the left of the mediastinum in the chest. The wider t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd