Artificial skin, Biology

Assignment Help:

Artificial Skin:

The skin generated in vitro is in fact the epidermis portion of skin only; when the epidermis is applied to the burnt part, this leads to the regeneration of dermis (remaining parts of skin) beneath. But improvements in the approach  have allowed the reconstitution of virtually complete skin (both epidermis and dermis), called as living skin equivalent (LSE); this technology uses a collagen matrix as a support for development of the tissue. The skin explants used for attaining artificial skin may be either obtained from the patient concerned or from the foreskin (loose skin from the tip of penis) of newborn. Skin cells of new-borns grow more strongly than adult skin; the use of a synthetic polymer called as PGA helps the newborn skin to develop with no scars. Artificial skin from newborn skin explants is used to wrap the wound until the patient's skin is cultured and artificial skin is gained for grafting.

The production of artificial skin is following   and this is particularly cell and not organ culture. The bulk (Ca 90%) of epidermis is constituted by cells that called keratinocytes which generated the dead cells (corneocytes) making up the outermost cornfield layers of skin. The keratinocytes are dissociated by treating the skin explants with trypsin. These cells are sophisticated in vessels the bottom of which is enclosed with irradiated 3T3 fibroblast cell line; this is because certain products from fibroblast cells facilitate the proliferation of keratinocytes. Keratinocytes develop to make colonies, which are again dissociated into single cells and cultured in the same manner. The process is repeated again and again till a confluent sheet of pure epithelium is completed; this sheet is detached from the culture vessels, cleaned and used for grafting. The explants for developing artificial skin for the graft might come from the patient himself to avoid rejection. A 3 cm2 skin explants may yield about 1.7 m2 artificial skin in 3-4 weeks representing a 5000-fold increase. In approximate 5 years after grafting of the artificial skin, all the essential components of skin are regenerated. Artificial skin grafts have been used to successfully repair several types of skin defects, including chronic skin ulcers.


Related Discussions:- Artificial skin

Define cooking, Define cooking,blanching and Canning - thermal processing? ...

Define cooking,blanching and Canning - thermal processing? Cooking: Cooking is a primary process to make food more palatable and improve taste. This is not used as a preservati

Why is it significant that exact copies of dna, Why is it significant that ...

Why is it significant that exact copies of DNA are produced during replication? Producing exact copies make sure that when a cell divides, the offspring cells will receive the

What do you mean by the spinal cord, Q. What is the spinal cord? Of which e...

Q. What is the spinal cord? Of which elements is the spinal cord constituted? The spinal cord is the dorsal neural cord of vertebrates it is the part of the central nervous sys

Define about the spectroscopy- colorimetry, Define about the Spectroscopy- ...

Define about the Spectroscopy- colorimetry? Spectroscopy, therefore, is the study of the absorption and emission of radiation by matter. Absorption Spectroscopy is usually used

Egg type, why their is different amount of yolk is present in eggs.

why their is different amount of yolk is present in eggs.

Explain protostomes vs. deuterostomes breifly, Explain Protostomes vs. Deut...

Explain Protostomes vs. Deuterostomes breifly? Branching Evolutionary Lines : It appears that the Coelomate animals separated into two divergent lines of evolution in terms o

Ventilation of tracheal system – passive suction ventilation, Ventilation o...

Ventilation of Tracheal System – Passive Suction Ventilation Many active insects and insects that live in environments where water is scarce cannot depend on diffusion alone t

Explain the toxicity of folate, Explain the Toxicity of Folate? There ...

Explain the Toxicity of Folate? There is no evidence to suggest that it is possible to consume sufficient natural folate to pose a risk of toxicity. However, this clearly does

Nonsurgical retreatment -secondary endodontic ttt, Nonsurgical retreatment ...

Nonsurgical retreatment (secondary endodontic ttt ) -Is the main difference between primary endodontic disease versus post treatment disease is the need to Regain access to

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd