Artificial skin, Biology

Assignment Help:

Artificial Skin:

The skin generated in vitro is in fact the epidermis portion of skin only; when the epidermis is applied to the burnt part, this leads to the regeneration of dermis (remaining parts of skin) beneath. But improvements in the approach  have allowed the reconstitution of virtually complete skin (both epidermis and dermis), called as living skin equivalent (LSE); this technology uses a collagen matrix as a support for development of the tissue. The skin explants used for attaining artificial skin may be either obtained from the patient concerned or from the foreskin (loose skin from the tip of penis) of newborn. Skin cells of new-borns grow more strongly than adult skin; the use of a synthetic polymer called as PGA helps the newborn skin to develop with no scars. Artificial skin from newborn skin explants is used to wrap the wound until the patient's skin is cultured and artificial skin is gained for grafting.

The production of artificial skin is following   and this is particularly cell and not organ culture. The bulk (Ca 90%) of epidermis is constituted by cells that called keratinocytes which generated the dead cells (corneocytes) making up the outermost cornfield layers of skin. The keratinocytes are dissociated by treating the skin explants with trypsin. These cells are sophisticated in vessels the bottom of which is enclosed with irradiated 3T3 fibroblast cell line; this is because certain products from fibroblast cells facilitate the proliferation of keratinocytes. Keratinocytes develop to make colonies, which are again dissociated into single cells and cultured in the same manner. The process is repeated again and again till a confluent sheet of pure epithelium is completed; this sheet is detached from the culture vessels, cleaned and used for grafting. The explants for developing artificial skin for the graft might come from the patient himself to avoid rejection. A 3 cm2 skin explants may yield about 1.7 m2 artificial skin in 3-4 weeks representing a 5000-fold increase. In approximate 5 years after grafting of the artificial skin, all the essential components of skin are regenerated. Artificial skin grafts have been used to successfully repair several types of skin defects, including chronic skin ulcers.


Related Discussions:- Artificial skin

Define sweetness as a function of sugar, Define Sweetness as a Function of ...

Define Sweetness as a Function of Sugar? Sweetness is the most recognized functional property of sweeteners. Our preference for sweetness, regarded as innate, is apparent soon

Enrobed meat products, E n r o b e d Meat Products Enrobing/coati...

E n r o b e d Meat Products Enrobing/coating of meat products with edible materials enhances the acceptability and creation of variety to meat products. Whole egg liquid,

Kingdom fungi, what are the characteristis in species in the phyla division...

what are the characteristis in species in the phyla division

Taxonomy, Agroup of realated genera are classified as-?

Agroup of realated genera are classified as-?

Explain phosphofiuctokinase-i, Phosphofiuctokinase-I Phosphofiuctokina...

Phosphofiuctokinase-I Phosphofiuctokinase-I  is activated by AMP and  inhibited by ATP and citrate. When ATP is utilized in energy requiring process, the concentration ofAMP

What are the uses of national parks, Q. What are the uses of National parks...

Q. What are the uses of National parks ? National Park is an area dedicated to conserve environment, natural and historical objects and to conserve the wild life therein. Natio

Pulmonary valvotomy cardio bypass and use cardioplegia, Pulmonary Valvo...

Pulmonary Valvotomy on Cardio Pulmonary Bypass and use of Cardioplegia :  Single aortic cannulation and separate SVC and IVC cannulation arc done. The cavae are snared to

Sociability - qualitative characters, Sociability (Gregariousness) Soc...

Sociability (Gregariousness) Sociability refers to the nature of grouping of individual plants, that is, whether they grow singly, in patches, in colonies or evenly intermixed

Which part of the cell have an excess of negative charge, Given how the Na+...

Given how the Na+/K+ pump works, which part of the cell (inside or outside) will have an excess of negative charge?

How are birds characterized, Q. Bird identity card. How are birds character...

Q. Bird identity card. How are birds characterized according to examples of representing beings, basic morphology, respiration, skin, nitrogen waste, circulation,thermal control an

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd