Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Antibody Structure:
An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment). Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class. Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.
Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14). The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1, CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2, FR3, FR4). The constant region of particular heavy chain has 3 homologous regions (CH1, CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).
Chuck Darwin knew BLENDING THEORY, but he also knew that if it was true his NOT work because
Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4
How Simple Transposition of the Great Arteries Present after 30 Days ? A switch operation will have poor results, as the ventricle that has regressed will not be able to mainta
Define Determinants of Food Security - Vulnerability? It is the fourth critical variable and defines the risk factor to which a person, family, community or nation is exposed o
Meat products Meat is an important commodity in the diet of people in view of its complimentary role in balancing the diet with rich source of amino acids, vitamins and mineral
Explain the Nutrition of Women during Pregnancy? During the post-war years, the people in the developed world recognized that women were at a disadvantaged position and felt th
What are pentoses? What are the roles of pentoses in DNA and RNA molecules? Pentoses are carbohydrates made of five carbons. The DNA molecule is made of a sequence of molecu
Indications for Surgery : Congenital pulmonic stenosis is the most common lesion requiring relief. Very rarely it could be due to rheumatic involvement along with disease of othe
Define drug-nutrient interaction and drug- drug interactions? Generally, administering oral medication along with the food or at a mealtime is a convenient manner of drug dosin
what is endosperm haustorium
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd