Antibody structure, Biology

Assignment Help:

Antibody Structure:

An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment).

Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class.

Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.

Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14).

The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2FR3FR4). The constant region of particular heavy chain has 3 homologous regions (CH1CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).


Related Discussions:- Antibody structure

Biologyical problem, Ask question #Minimum 100 hhejejhjehjwords accepted#

Ask question #Minimum 100 hhejejhjehjwords accepted#

Coelom - metazoa, Coelom - Metazoa True coelom is a body cavity which ...

Coelom - Metazoa True coelom is a body cavity which arises within the embryonic mesoderm so that the cavity lies between the body wall (integument; ectoderm) and guts (endoder

Marine extremophiles, how to make a assignment on recent research on marine...

how to make a assignment on recent research on marine microbiology

Food chain - ecosystem, Food Chain - Ecosystem In a food chain, the fo...

Food Chain - Ecosystem In a food chain, the food energy is transformed from a given source through a series of species, each of which eats the one before itself in the chain.

Determine the process of rna editing, Which of the following is a true stat...

Which of the following is a true statement regarding the process of RNA editing? A. RNA editing alters the sequence of the mRNA message thereby permitting for an enhance in pro

Define the plasma membrane and its function, Similar to all animal cells, p...

Similar to all animal cells, protozoans are covered by a plasma membrane which surrounds cytoplasm of the cell, protozoan's integument or skin. Like all membranes, it's permeable;

Define feeding and nutritional management of spinal trauma, Define the Feed...

Define the Feeding and Nutritional Management of spinal trauma? The main objectives of nutritional management are to meet the nutritional needs of the initial acute phase and

Explain corrective surgery - endodontic surgery, Explain Corrective Surgery...

Explain Corrective Surgery - Endodontic Surgery perforation repair periodontal management (root resection, tooth resection) intentional reimplantation

Sequence was found in a 21 base dna polymer., Suppose the following base se...

Suppose the following base sequence was found in a 21 base DNA polymer. 3' TAC   TTA   GGC   TCC    GTT    CAG   ATT       5' 1. Provide the nucleotide sequence complementary

Define nutritional needs of the elderly, Define Nutritional Needs of the El...

Define Nutritional Needs of the Elderly? In this, we learnt about the nutritional needs of the elderly, and in doing so we have also focused on many other aspects such as who d

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd