Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Antibody Structure:
An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment). Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class. Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.
Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14). The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1, CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2, FR3, FR4). The constant region of particular heavy chain has 3 homologous regions (CH1, CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).
Q. Explain States of matter Ans. Chemistry deals with the nature and composition of matter - anything that occupies space and has mass, and the changes which it undergoes. Matt
Q. What are the few examples of the energetic function of organic molecules? Ans. Since they are complex molecules, organic molecules store large amount of energy, present
You will be learning about vitamins and minerals (micronutrients) over a 2 week span. Remember phytochemicals from the Controversy section of chapter 2? They are not vitamins, b
What is the difference between an acid and a base? Base is anything, which has a capability to abstract a proton. Using the easiest definition, an acid is something when add
What are the major features of the meristematic cells? And why do these cells need to have a high mitotic rate? The Meristematic cells have very thin cell walls, a well-central
Nuclear Type - Endosperm The primary endosperm nucleus divides. The cell wall is not laid. These nuclei and their division products form a large number of free nuclei. The fi
Non-succulent perennials These are actually the true xerophytes or drought resistants, because they possess a number of morphological, anatomical and physiological characterist
Q. What do you know by Hemodynamic Responses? Reduced exercise capacity roughly reflects impaired LV function, and may contribute its prognostic value to this association. Comp
Echocardiography Utilizes principle of ultrasound for visualization of heart and great vessels. It uses sound in the frequency of 1-10 MHz. As the frequency of probe increase
What is the other name given to sex chromosomes? What is the function of sex chromosomes? Sex chromosomes are also known as allosomes (the other chromosomes that are not sex ch
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd