Antibody structure, Biology

Assignment Help:

Antibody Structure:

An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment).

Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class.

Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.

Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14).

The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2FR3FR4). The constant region of particular heavy chain has 3 homologous regions (CH1CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).


Related Discussions:- Antibody structure

Explain signal hypothesis, A classical secretory protein vary from a cytoso...

A classical secretory protein vary from a cytosolic protein by having a sequence about 13-35 amino acids long at its N-terminal end called as a signal peptide or signal sequence.

Define the diet intervention for lactose intolerance, Define the Diet inter...

Define the Diet intervention for lactose intolerance? Lactose is present in dairy products such as milk, cheese, yoghurt, ice cream etc.  Hidden sources of lactose may include

Ribonucleases and deoxyribonucleases, Ribonucleases  and  deoxyribonuclea...

Ribonucleases  and  deoxyribonucleases These enzymes  are  responsible  for  the degradation of  dietary  nucleic acids. Ribonucleases  and  deoxyribonucleases secreted by  the

What are polyclonal antibodies, Antibodies of dissimilar specificities, whi...

Antibodies of dissimilar specificities, which react to the same antigen, are known as polyclonal antibodies.

Amphibian circulation be classified as incomplete and double, Q. Why can th...

Q. Why can the amphibian circulation be classified as incomplete and double? The amphibian circulation is double because it is composed of pulmonary and systemic circulations r

What are trophic levels, What are trophic levels? How many trophic levels c...

What are trophic levels? How many trophic levels can a food chain have? The Trophic levels correspond to positions on a food chain. thus producers always belong to the first tr

Phases of seed formation, Phases of Seed Formation The process of seed...

Phases of Seed Formation The process of seed formation can be divided into two phases: The division phase, in which fertilised egg divides mitotically and complet

Explain a reason these cells are used instead of outer body, The cells lini...

The cells lining the inside of the cheek are frequently removed for making observations of basic cell structure. The cells are from stratified squamous epithelium. Explain a reason

Relation between fecundation and end of the meiotic process, Q. What is the...

Q. What is the relation between fecundation and the end of the meiotic process during oogenesis? The oocyte II only completes the second meiotic division (interrupted at metaph

Describe how to prepare 200 ml of naoh, Describe how you would prepare 200 ...

Describe how you would prepare 200 ML of a 0.25 Msoluation of NaOH from a 3 M stock solution?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd