Antibody structure, Biology

Assignment Help:

Antibody Structure:

An antibody molecule consist of two alike light chains (220 amino acids each) ad two similar heavy chains (about 440-450 amino acids each) held together by disulfide bridges; this create the monomeric form of antibody. Enzymes papain cleaves particular monomeric form into two fragments that bind to the antigen (designated as FAB; fragment with antigen binding) and one fragment which does bid to antigen but make crystals (so it's called Fc, crystal forming fragment).

Approximate 100 amino acid long amino-terminal ends of both light and heavy chains add up to their variable region denoted VL and VH, correspondingly; the amino acid sequence of this regions of the heavy and light chains are known constant region (designated as CH and CL, correspondingly) as there is little variation in the amino acid sequence of this region between the antibodies belonging to the same class.

Every antibody molecule has two antigen-binding domains or sites, particular domain being constituted by the variable regions of one light and one heavy chains of an antibody molecule form its effectors function domain that determines its interaction with the other components of the immune system. The light chains are of two types: and lambda (λ) and Kappa (K) ; the type of a light chain is find out by its constant region.

Different genes encode the Kappa (located in human chromosome 2) and lambda (chromosome 22) light chains, and the heavy chain (chromosome 14).

The variable region of particular chain contains 3 highly variable regions known hyper variable regions and denoted as CDR1CDR2and CDR3 (CDR = complementarily-determining region) divided by 4 constant regions known framework regions (this is designated as FR1, FR2FR3FR4). The constant region of particular heavy chain has 3 homologous regions (CH1CH2 and CH3) which most likely originated from a common parental gene (3 tandem repeats of the parental gene, by following mutations).


Related Discussions:- Antibody structure

Botany, what is affinites of gymnosperm

what is affinites of gymnosperm

Illustrate goal of modern dentistry, Q. Illustrate goal of modern dentistry...

Q. Illustrate goal of modern dentistry? The goal of modern dentistry is to restore the patient to normal contour, comfort, function, esthetics, speech and health regardless of

What do you mean by endemic goiter, Q. What is a goiter? What is endemic go...

Q. What is a goiter? What is endemic goiter? How this problem is socially solved? Goiter is the abnormal enlargement of the thyroid gland the goiter appears as a tumor in the a

Mechanism of movement of chromosomes, The movement of the chromosome is cal...

The movement of the chromosome is called anaphase A, and the extension of the poles is termed anaphase B.The mechanism of these movements are discussed below. Chromosome move

What are the uses of formycin b, What are the uses of formycin B? Formy...

What are the uses of formycin B? Formycin B is a drug used to demolish of intestinal parasites.

What are cytokines, What are Cytokines? Cytokines are polypeptides, whi...

What are Cytokines? Cytokines are polypeptides, which influence the proliferation, differentiation, metabolism and activation of cells. There are three areas in cancer that hav

Fungi, Candida albicans, and Aspergillus species are the most common of the...

Candida albicans, and Aspergillus species are the most common of the many fungal organisms identified as causing IE. Fungal endocarditis arises in specific settings. Valve replace

Mouse bioassay and mongoose bioassay, Question: (i) Which species of m...

Question: (i) Which species of microalgae are associated with ciguatera fish poisoning? (ii) Name five fish species generally implicated in ciguatera fish poisoning in Mau

What is the autotrophic hypothesis on the origin of life, What is the autot...

What is the autotrophic hypothesis on the origin of life? An autotrophic hypothesis on the origin of life asserts that the first living beings on earth were producers of their

What is the importance of vitamin A, What is the importance of vitamin A ...

What is the importance of vitamin A The importance of vitamin A is undisputable. You may already be aware about the functions/role of vitamin A in our body.  Vitamin A is absol

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd