Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Transgenic animals, T ra n sge n i c animals There are various d...

T ra n sge n i c animals There are various definitions for the term transgenic animal . The transgenic animal is an animal in which there has been a deliberate modifica

Phylum echinodermata, PHYLUM ECHINODERMATA Definition  and Indroductio...

PHYLUM ECHINODERMATA Definition  and Indroduction Bilateral and deuterostomial  eucoelomate  eumetazoa  with rough , tough and  leathery skin  due  to a dermal skeleton o

What are the three main types of trophic pyramids, What are the three main ...

What are the three main types of trophic pyramids studied in Ecology? The three types of trophic pyramids studied in Ecology are the numeric pyramid, the biomass pyramid and th

Chromosomes in a cell, Two chromosomes in a cell have identical length and ...

Two chromosomes in a cell have identical length and centromere position yet are not homologous, what is different about them

Acute mitral regurgitation-mitral regurgitation, Acute Mitral Regurgitation...

Acute Mitral Regurgitation :  This may be caused by chordal rupture, infective endocarditis or acute myocardial infarction. In acute myocardial infarction, one of the papilla

What is ecosystem, Question 1 Write a short note on the following         ...

Question 1 Write a short note on the following                       1 Angiosperms                       2 Meristematic tissue Question 2 What is ecosystem? List and explain

Transplantation, Transplantation - It is implanting of a living or p...

Transplantation - It is implanting of a living or preserved tissue or organ from one site to another side in the same individual or from one individual called donor to recip

Smoking, SMOKIN G - It means to draw tobacco smoke into the mouth o...

SMOKIN G - It means to draw tobacco smoke into the mouth or lungs & exhale it via mouth, nostrils or both. Tobacco is obtained from Nicotiana tobacum & Nicotiana r

Non-ketotic hyperosmolar diabetic coma, Non-Ketotic Hyperosmolar Diabetic C...

Non-Ketotic Hyperosmolar Diabetic Coma (NKHDC) is another acute complication of diabetes mellitus. In this condition, the coma (loss of consciousness) is developed due to high blo

Digestive system in cockroach, DIGESTIVE SYSTEM IN COCKROACH ALIMEN ...

DIGESTIVE SYSTEM IN COCKROACH ALIMEN T A R Y CANAL 6-8 cm. long. Coiled, present from mouth to anus. Differentiated into 3 parts -      1. Foregut            2. M

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd