Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Role of wound epidermis and apical epidermal cap, Role of Wound Epidermis a...

Role of Wound Epidermis and Apical Epidermal Cap Earlier described that amputation, the stump epidermal cells at the wound edge migrate over and quickly cover the wound to fro

Explain in brief about life style modification, Explain in brief about Life...

Explain in brief about Life style modification Life style modification in simpler words, means  diet control and doing exercises. Diet control and exercise should be planned on

Growth at different levels, GROWTH AT DIFFERENT LEVELS - 1.      Molec...

GROWTH AT DIFFERENT LEVELS - 1.      Molecular level - It involves synthesis of new molecules and their aggregation into organellae. 2.      Cellular level - It includes

Define clinical manifestations associated with cancer, Define Clinical Mani...

Define Clinical Manifestations and Nutritional Problems Associated with Cancer? In the previous section we learnt that cancer results in several changes in the metabolism of ca

Define term food colours, Normal 0 false false false EN...

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4

Explain citric acid cycle, Explain citric acid cycle In  the citric aci...

Explain citric acid cycle In  the citric acid cycle, the oxaloacetate is first condensed with acetyl CoA, and  then regenerated  as  the cycle  is  comp!eted.  But these  react

Respiration, abnormal lung volumes and capacities

abnormal lung volumes and capacities

Measuring biodiversity, Conservation and management of biodiversity require...

Conservation and management of biodiversity require measurement of biodiversity because it is important to make choices about "what, where, and how" to conserve. Measurement can be

What is cardiac catheterization, Q. What is Cardiac Catheterization? Ro...

Q. What is Cardiac Catheterization? Routine cardiac catheterization is not necessary in patients with mitral regurgitation. It may be done when there is discrepancy between cli

Regulation of breathing and blood pressure, Q. Which is the brain region re...

Q. Which is the brain region responsible for the regulation of breathing and blood pressure? The neural regulation of breathing, blood pressure and other physiological paramete

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd