Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Physiology, Slacklining is the act of walking across a suspended nylon stra...

Slacklining is the act of walking across a suspended nylon strap tied between two vertical anchor points. List the senses used to maintain an upright position while slacklining an

Define dietary management of cancer patients, Define Dietary Management of ...

Define Dietary Management of Cancer Patients and Feeding Problems Related To Cancer Therapy? We took an overview about the general nutritional requirements of cancer patients.

List various liver function tests, Question 1 List various liver function ...

Question 1 List various liver function tests. Discuss the importance of each test. Add a note on standardization of various liver function tests Question 2 Discuss the follow

Cartilaginous and the osseous tissue, Q. Which kind of tissue are the carti...

Q. Which kind of tissue are the cartilaginous and the osseous tissue? The osseous and the cartilaginous tissues are considered connective tissues since they are tissues in whic

Define stage - parts of the microscope, Define Stage - Parts of the Microsc...

Define Stage - Parts of the Microscope? It is a fixed platform positioned about halfway up the arm and provide surface for keeping the slide. Slide is held in position either b

What is phylum hemichordata, What is Phylum Hemichordata ? The name "he...

What is Phylum Hemichordata ? The name "hemi"; (meaning "half") provides a clue to these animals, which have some of the features of chordates, and some features that are chara

What are phenotypical & genotypical proportions in f1 & f2, According to th...

According to the Mendel's second law, in the crossing between homozygous individuals concerning two pairs of nonlinked alleles, AABB x aaBB, what are the phenotypical and genotypic

List a few applications of starches in the food industry, List a few applic...

List a few applications of starches in the food industry. A few applications of starches in the foods industry include thickener, a fat sparing agent, adhesive, binder,

What is defective colour vision, What is Defective Colour Vision Defect...

What is Defective Colour Vision Defective colour vision is often called colour blindness. The ability to appreciate one or more of the primary colours is lacking. This can be e

Define resolution - terminologies used in chromatography, Define Resolution...

Define Resolution - terminologies used in chromatography? Resolution is the effectiveness of the separation and is determined by two factors. These include: Distance

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd