Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Formation of gemmules, Formation of Gemmules Throughout the formation...

Formation of Gemmules Throughout the formation of gemmules, masses of food - laden amoebocytes called archaeocytes feed on other cells and lay down in within them. They get s

Explain the types of basic forces, Q. Explain the types of basic forces? ...

Q. Explain the types of basic forces? Compression: This refers to the squeezing of the test material so that it still remains as a single undivided unit but may occupy less v

List a few important uses of food hydrocolloids, List a few important uses ...

List a few important uses of food hydrocolloids. A few important uses of food hydrocolloids are: to increase viscosity and to stabilize food products. Its other uses  include u

Cadmium, C adm iu m Like lead and mercury, cadmium is also non-essen...

C adm iu m Like lead and mercury, cadmium is also non-essential biologically. The industrial use of cadmium in plastic production, electroplating and manufacture of alloys a

Nutrition, define alimentary canal

define alimentary canal

Why is carbon monoxide toxic for humans, Why is carbon monoxide toxic for h...

Why is carbon monoxide toxic for humans? Hemoglobin "likes" carbon monoxide (CO) much more than it likes oxygen. When there is carbon monoxide in the inhaled air it binds to he

Define effect of protein deficiency during pregnancy period, Define effect ...

Define effect of Protein deficiency during pregnancy period? The effects of protein deficiency during pregnancy are difficult to separate from the effects of caloric deficit, s

Determine about the manganese, Determine about the Manganese   Manganes...

Determine about the Manganese   Manganese performs some functions in photosynthesis and acts to regulate the intake of certain elements and their oxidation states.   Several cr

Define the classification of proteins, Define the Classification of Protein...

Define the Classification of Proteins? Proteins vary widely in. their properties. We suggest you look up this unit once again now as the information about proteins and their pr

Beta decay, Beta decay  is the type of radioactive decay in which the radio...

Beta decay  is the type of radioactive decay in which the radioisotope emits a little negatively-charged and fast-moving particle from its nucleus. A beta particle is almost simila

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd