Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Secondary production - ecosystem, Secondary Production - Ecosystem Th...

Secondary Production - Ecosystem The net primary production is the only energy available to consumers or heterotrophs including man. Herbivores such as cow or deer gaze upon

Blank titration for determination of iodine number of lipids, Define Blank ...

Define Blank titration for Determination of the Iodine Number of Lipids? Using an autopipette, measure 25 ml of Hanus iodine reagent accurately and transfer into a 250 ml iodin

Define intracellular fluid or the water within the cells, Define intracellu...

Define intracellular Fluid or the water within the cells? The intracellular Fluid or the water within the cells makes up about 40-4596 of the total body weight. Because the bod

What is bioremediation, What is bioremediation? Bioremediation is the u...

What is bioremediation? Bioremediation is the use of microorganisms, as bacteria, protists and fungi, to degrade noxious substances turning them into non toxic or less toxic su

What are the results of pulmonary artery banding, What are the Results of p...

What are the Results of pulmonary artery banding ? Results of surgery for ventricular septa1 defects are excellent. Though the mortality is not 0 per cent, in a large series it

What are the phytoplankton and the zooplankton?, What are the phytoplankton...

What are the phytoplankton and the zooplankton? The Phytoplankton and the zooplankton are divisions of the plankton. The phytoplankton includes the autotrophic floating beings:

Explain about the texturization, Explain about the Texturization? Prote...

Explain about the Texturization? Proteins constitute the basis of structures and texture in several foods, whether these come from living tissue (myofibrills in meat or fish) o

How can amine groups be classified, Q. How can amine groups be classified? ...

Q. How can amine groups be classified? Amines can be classified into primary amines, those to which one -R (variable radical) is attached to a -NH 2 , secondary amines, those w

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd