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Animal disease model
The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.
Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.
In genetic recombination by crossing over what is the difference between parental gametes and recombinant gametes? The Parental gametes are those gametes that maintain the orig
Explain Precautions for capsule staining in a culture? 1. Never heat fix the smear. This is because by heating shrinkage can occur which may create a clear zone around the cell
REHABILITATION OF CARDIAC SURGICAL PATIENTS The goal of nursing care of cardiac surgical patient is to make the patient to come back to his normal activities. Cardiac surgica
Following are the advantages of the DSME: It enables the patient to 1. Accept the disease. 2. Gain knowledge about disease, its prevention, treatment and management. 3.
newer trends of animal taxonomy
Locomotion,nutrition and reproduction in ptotozoa
Define Calcium - The Macronutrient? Calcium is an important mineral found mainly in bone and teeth. It is widely distributed in food substances such as milk, cheese, egg yolk,
Chelating agents Oxalates: Only a few plants contain sufficient amounts of sodium and potassium oxalate to be considered toxic. Moreover, ruminants that consume these plants
EXCRETION IN PRAWN- A pair of antennary gland or green gland and a median renal sac present. Green glands lie at the base of antennae & open out by renal aperture.
Symbiotic interaction - Biological Stress Presence of symbiotic microorganism can result in differential growth stimulation of those plants which can recognise the beneficial
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