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Animal disease model
The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.
Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.
It is IgE mediated hypersensitivity. Typical manifestations contain asthma, food allergies, eczema, hay fever etc.
Constrictive Pericarditis : It is usually the end stage of inflammatory process involving pericardium. In developing world, infection with mycobacterium tuberculosis is still com
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To study the conditions essential for the germination of seeds:- In the diagram below a having seeds on cotton wool with air, warmth, but no water; b has water, warmth, but no
Dextrins Dextrins are also polymers of D-glucose held by a(l,4) glycosidic linkages. Dextrins are, in fact, formed due to partial hydrolysis of starch by enzymes such as sa
Determine the Factors that Influence manganese absorption? Let us now see which factors influence Mn absorption. Major factors which may influence the absorption of this min
In Dental Traumatology Traumatic injuries in young kids (8 to 14 years old male > female) are commonly nowadays. Dental traumatic injuries are mostly in anterior teeth
Q. Is the interphase of mitosis different from the interphase of meiosis? The interphase mitosis that proceeds is similar to the interphase that precedes meiosis. In them the m
Explain how you would create a standard curve to determine the amount of orange dye that had been added to a can of orange soda
Why is the number of bonds important in nucleic acids
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