Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Define food availability and food access, Define Food availability and Food...

Define Food availability and Food Access? Food availability: This refers to availability of necessary types of food in sufficient quantity, to the individual. The sources may b

How computed tomography helps the doctors, Explain briefly how computed tom...

Explain briefly how computed tomography (CT) helps the doctors in pinpointing the defects in the patient's body

Define the cell structure and function, Cell structure and function All...

Cell structure and function All organisms, whether simple or complex, plants or animals. are composed of cells. For example, a bacterium or an amoeba is made up of just one cel

Hydropower, Energy from water or hydropower            Hydroelectrici...

Energy from water or hydropower            Hydroelectricity is the energy produce from the kinetic energy of water falling from height. Approximately 25% of world electricity

What organisms make glycogen, What organisms make starch? What is it used f...

What organisms make starch? What is it used for? What organisms make glycogen? What is it used for?

Possible factors contributing to environmental disasters, 1.      The Combi...

1.      The Combination Of Rapid Industrial Growth, Lack Of Regulations, Inadequate Supervision Of Safety Measures By The Authorities And Lack Of Sufficient Opportunities For The L

Haemodynamics of tricuspid regurgitation, Q. Haemodynamics of Tricuspid reg...

Q. Haemodynamics of Tricuspid regurgitation? Right Atrial pressure tracing shows a prominent ‘v' wave and these cannot be appreciated in a patient with atrial fibrillation. RV

Biomolecules, How do you explain in the absence of aldehyde group in the pe...

How do you explain in the absence of aldehyde group in the pentaacetate of D-glucose? Ans) when you react glucose with acetic anhydrate it forms pentaacetate with 5 OH grops it tel

Can pathophysiology causes cardiovascular disease, Q. Can Pathophysiology c...

Q. Can Pathophysiology causes cardiovascular disease? Cigarette use activates platelets, increases circulating fibrinogen, increases heart rate, and elevates blood pressure. It

Respiration in cockroach, what is the chemical reaction of respiration in c...

what is the chemical reaction of respiration in cockroach?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd