Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Define pectin, Pectin The word pectin is derived from a Greek word whic...

Pectin The word pectin is derived from a Greek word which means to "congeal or solidify". Pectin is an acidic structural polysaccharide, found in fruit and vegetables and mainl

Explain the food preparation and cooling - canning, Explain the Food prepar...

Explain the Food preparation and Cooling - Canning? Food preparation - Preparation methods will change with the type of food. For fruit, cutting to size, washing, grading, peel

Diet for cardiac patients, Diet Continue diet as prescribed at hospita...

Diet Continue diet as prescribed at hospital. Some may continue fluid and salt restriction, some may have to restrict iron and Vitamin K rich food stuff. The patient needs t

Explain vegetable sterilization process, Explain vegetable sterilization pr...

Explain vegetable sterilization process Canning, which involves heat sterilization, is one of the most important processes in vegetable preservation. As compared to other foods

State the layers of retina, State the Layers of retina The retina is c...

State the Layers of retina The retina is coil~posed of ten layers: a) Pigmented epithelium (outermost layer), b) Neusoepithelium, rods and cones (photoreceptors), c) Exte

Determine the bioavailability of minerals, Bioavailability of Minerals ...

Bioavailability of Minerals It is well known that the concentration of a nutrient in a food is not a reliable indicator of its nutritional value. In other words, the entire qua

Types of ecosystem, Types of Ecosystem Basically ecosystems are of two ...

Types of Ecosystem Basically ecosystems are of two types : terrestrial and aquatic. If you travel from plains to the mountains in the Himalayas, you notice significant changes

Computer architecture help required, I need help in pipeline processing in ...

I need help in pipeline processing in computer architecture.

Illustrate chloroplast structure, Q. In which chloroplast structure are chl...

Q. In which chloroplast structure are chlorophyll molecules found? Chlorophyll molecules are placed in an organized manner in order to improve the exposure to light on the thyl

Open and closed type of circulatory systems, Open and Closed Type of Circul...

Open and Closed Type of Circulatory Systems There are two categories of circulatory system found in higher metazoans. In one type the original blastocoel carries on to be the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd