Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Galvanotaxis - modes of cell movement, Galvanotaxis - Modes of Cell Movemen...

Galvanotaxis - Modes of Cell Movement Galvanotaxis considers to the movement of cells in response to a potential variation between cells. It is suggested that there are voltag

State the study of linked genes, Why is drosophila a convenient animal for ...

Why is drosophila a convenient animal for the study of linked genes? The fruit fly drosophila is suitable for the study of Genetics because it shows many distinct traits but on

Electron transport inhibitors, Electron Transport Inhibitors Several  c...

Electron Transport Inhibitors Several  compounds, including specific drugs, chemicals  and antibiotics  have been known to inhibit the electron  transfer  reactions at specific

What is spermatogenesis in human biology, What is Spermatogenesis in human ...

What is Spermatogenesis in human biology? The male sex cells, or sperm, are produced in the oval-shaped testes, the primary sex organs of the male reproductive system, in a pro

Explain the expanding frontiers of nutrition, Explain the Expanding Frontie...

Explain the Expanding Frontiers of Nutrition? While the essential nutrients mentioned in Table are indispensable and our diets need to provide them all in adequate quantities,

Explain zipping of the apical canal, Explain Zipping of the Apical Canal ...

Explain Zipping of the Apical Canal a. If the preparation is continued with progressively larger and stiffer file lead to : zipping perforation or tear apical foramen.

Define larval stage of taenia cystcercus, Define Larval Stage of Taenia Cys...

Define Larval Stage of Taenia Cystcercus? The pork tapeworn (T: solium) and beef tapeworn (T : saginata , which are endoparasites of humans who are the final hosts

Which term explains to pituitary gland, In studies of human body, which of ...

In studies of human body, which of the subsequent terms can also be used when referring to the pituitary gland? Is it: a) Pancreas b) Hypozthesis (pron: hypo-fi-sis) c) T

Biochemestry, what are peptides and poly peptides hormones

what are peptides and poly peptides hormones

Which represents the least potential electromotive force, In a neuron with ...

In a neuron with a resting potential of -65 mV, the distribution of which ion across the neuronal membrane represents the LEAST potential electromotive force (EMF)? A. Potassium

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd