Animal disease model, Biology

Assignment Help:

Animal disease model

The second area of transgenic application in agriculture is to develop lines of animals resistant to some specific damaging diseases. While the genes of interest may be expressed in the transgenic animals, so far there have been no projects that have progressed to the development of disease resistant animal lines. Prion diseases have had a major economic impact arid are a concern in the use of animal products for human use. This is particularly the case for BSE in cattle, and it is now almost certain that this has caused a new and terrible form of Creuzfeldt Jacob disease (CJD) in humans termed vCJD. Scrapie has been described in sheep for many years and, from the evidence of PrP knockouts in the mouse, removal of the PrP gene itself by gene knockout would be expected to produce animals resistant to prion diseases, without detrimental side effects.

Knockout of the Cftr gene in the sheep would be expected to produce a more accurate model of cystic fibrosis in humans due to similarities in lung physiology between sheep and humans. Furthermore sheep lungs are similar in size to those of humans thus enabling medical interventions delivering new drugs or therapy with the Cftr gene to be evaluated more realistically. There are of course major ethical issues which would have to be considered in generating potentially sick animals and these would have to be balanced alongside the practical benefits such a model could bring.


Related Discussions:- Animal disease model

Explain what is organismal ecology, Explain what is Organismal Ecology? ...

Explain what is Organismal Ecology? Ecology at the Level of Individuals: We define ecology as the study of the relationships between organisms and the relationships between o

Can you explain pneumothorax, Q. Can you explain Pneumothorax? Air in t...

Q. Can you explain Pneumothorax? Air in the pleural cavity manifests in a number of ways on the CXR, depending on the volume of air and position of the patient. The typical fin

Explain the filtration - air sampling, Explain the Filtration - Air Samplin...

Explain the Filtration - Air Sampling? Filtration - Air stream may also be filtered through a micro-filter.  Microorganisms are released from the filter using a suitable diluen

Explain the tubal ligation, Explain the Tubal Ligation   This process i...

Explain the Tubal Ligation   This process is the most commonly utilized method of female sterilization. Tubal ligations are generally done in an outpatient surgical center. Thr

Explain the properties of gum tragacanth, Explain the Properties of Gum tra...

Explain the Properties of Gum tragacanth Gum tragacanth swells in water to give thick  viscosity dispersions or pastes similar in texture to soft gels. The viscosity shows a sh

What are zymogens, What are zymogens? Zymogens, or proenzymes, are enzy...

What are zymogens? Zymogens, or proenzymes, are enzymes secreted in inactive form. Under some conditions a zymogen shifts to the active form of the enzyme. Zymogen secretions i

CELL, ORGNELS WITH SINGLE WALL

ORGNELS WITH SINGLE WALL

Dna replication in eukaryotes, DNA replication in eukaryotes is much more c...

DNA replication in eukaryotes is much more complex than in prokaryotes while there are various same aspects. The Eukaryotic cells can only initiate DNA replication at a particular

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd