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Alternative polyadenylation sites
Exact pre-mRNAs hold more than single group of signal sequences for 3' end polyadenylation and cleavage. In some cases, the area of the instead polyadenylation sites is like which, depending on the site chosen, certain exons should be lost or retained in the subsequent splicing reactions that is shown in the figure. Here the effect is to change the coding capacity of the last mRNA so which variant proteins are formed depending on the polyadenylation site used. In other cases, the instead sites both lie within the 3' noncoding region of the pre- mRNA so in which the same coding sequences are involved in the last mRNA irrespective of that site is used but the 3' noncoding region can vary. Since the 3' noncoding series should have signals to control mRNA stability, the choice of polyadenylation site in this location can affect the lifetime of the resulting mRNA.
Figure: Use of alternative polyadenylation sites.
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