You are interested in integrin activation and perform

Reference no: EM13395720

You are interested in integrin activation and perform mutagenesis studies on integrin. You find a mutant form of integrin which you call int-act, because the int-act mutation causes the extracellular domain to exist always in an unfolded state regardless of the presence or absence of ligand. When you determine the sequence of int-act, you find that the mutation is in the intracellular domain of integrin. Explain how this intracellular mutation could affect the conformation of the extracellular domain of integrin.

Reference no: EM13395720

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