Reference no: EM131026636
Metallic elements are essential components of many important enzymes operating within our bodies. Carbonic anhydrase, which contains Zn2+in its active site, is responsible for rapidly interconverting dissolved CO2 and bicarbonate ion, HCO3-.The zinc in carbonic anhydrase is tetrahedrally coordinated by three neutral nitrogen-containing groups and a water molecule. The coordinated water molecule has a pKa of 7.5, which is crucial for the enzyme's activity.
(a) Draw the active site geometry for the Zn(II) center in carbonic anhydrase, just writing "N" for the three neutral nitrogen ligands from the protein.
(b) Compare the pKa of carbonic anhydrase's active site with that of pure water; which species is more acidic?
(c) When the coordinated water to the Zn(II) center in carbonic anhydrase is deprotonated, what ligands are bound to the Zn(II) center? Assume the three nitrogen ligands are unaffected.
(d) The pKa of [Zn(H2O)6]2+ is 10. Suggest an explanation for the difference between this pKa and that of carbonic anhydrase.
(e) Would you expect carbonic anhydrase to have a deep color, like hemoglobin and other metal-ion containing proteins do? Explain.
|
Write formula of compound using brackets to denote manganese
: The remainder of the compound is oxygen. An aqueous solution of the complex has about the same electrical conductivity as an equimolar solution of K4[Fe(CN)6]. Write the formula of the compound, using brackets to denote the manganese and its coord..
|
|
Calculate the monthly payment for the loan taken
: Which of the following equations describe the same line as the equation
|
|
Is co in the same oxidation state in these complexes
: When compound A is treated with AgNO3(aq), no reaction occurs, whereas compound B reacts with AgNO3(aq) to form a white precipitate.When compound A is treated with BaCl2(aq), a white precipitate is formed, whereas compound B has no reaction with B..
|
|
Describe the vital role of occupational health
: Describe the vital role of Occupational health and safety Management and its development in the workplace - Describe occupational health and safety issues such as accident and their affects, roles and professional certifications for safety and heal..
|
|
Would you expect carbonic anhydrase to have a deep color
: The coordinated water molecule has a pKa of 7.5, which is crucial for the enzyme's activity. Draw the active site geometry for the Zn(II) center in carbonic anhydrase, just writing "N" for the three neutral nitrogen ligands from the protein.
|
|
Write the balanced chemical equations of the marsh test
: Antimony is the only potential interferent, as it reacts similarly to arsenic and produces a similar silvery-black film; however, antimony does not dissolve in a solution of sodium hypochlorite, but arsenic does. Therefore, the completion of the M..
|
|
Apply the hahn-banach theorem to these linear equations
: Hint: Suppose that M is a finite dimensional subspace of and is a basis for M. Define linear functionals : M K by for in K, k=1,2,...,n. Apply the Hahn-Banach Theorem, and look at the kernels of the linear functionals.
|
|
Identify a invention that changed history of medicine
: Identify a significant discovery or invention that changed the history of medicine. Make sure to describe, in detail, the discovery or invention and how it benefited health care.
|
|
Draw the lewis dot structure of borazine
: Borazine, (BH)3(NH)3, is an analog of C6H6, benzene. It can be prepared from the reaction of diborane with ammonia, with hydrogen as another product; or from lithium borohydride and ammonium chloride, with lithium chloride and hydrogen as the othe..
|