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Problem
Sertraline although it is in the category of SSRIs is the most dopaminergic of all. So this is a good agent to prescribe for someone with a diagnosis of MDD who have little energy, no motivation, loss of appetite. This has been referred to an anergic depression in the past.
I do avoid it in those with any component of anxiety as you know the dopamine can worsen symptoms of anxiety at least initially.
Escitalopram is considered the best option and has the least amount of CYP450 drug mediated interactions.
Why would it be imperative to complete a MDQ prior to prescribing an SSRI?
Stahl, S. M. (2021).? Stahl's essential psychopharmacology:?Neuroscientific basis and practical applications (5th ed.).?Cambridge University Press.
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