Reference no: EM133726360
Assignment: How to Work a Case Study in Pathophysiology
Case Study Involving Pancreatitis
For the last 12 hours Belinda has been having an abrupt onset of deep epigastric pain accompanied with nausea, vomiting, perfuse sweating, abdominal tenderness, and a fever of 102 oF. Once admitted to the hospital the lab work reveals leukocytosis, elevated serum amylase, and elevated serum lipase, hypocalcemia, and elevated serum bilirubin. Belinda has proteinuria, glycosuria, hyperglycemia, and her serum ALT is 165. There is evidence from a CT scan that Belinda has been passing periodic gallstones and there is bile reflux in the pancreatic duct. She is very weak and she has a distended abdomen.
I. Considering Belinda's diagnosis, what would be causing the inflammation occurring in her case? Would you classify this as an acute or chronic form of inflammation? Explain your answers.
II. What is responsible for causing the elevation of the pancreatic enzymes and hyperglycemia in this disease condition?
III. Why would Belinda be experiencing abdominal pain? Fever? Vomiting? Explain why each of the lab results be occurring in pancreatitis?
IV. Looking at the vascular response that occurs in inflammation, what is the evidence that each step in that process is occurring? What is the evidence that the cellular response of inflammation is occurring in this case?
V. Would symptoms of jaundice be expected in Belinda's case? Explain. If so, what would be the reason for Belinda to be jaundice?
VI. (i) Explain the process that leads to fat necrosis. (ii)Explain how Belinda's current condition could progress to necrotizing pancreatitis?
VII. If pancreatic abscess were to develop, how would Belinda's condition change? What exudate would be found to confirm? What are the specific symptoms of this condition?