Why lactic acidosis results in these patients

Reference no: EM133289911

Assignment:

Question

Metabolism

Mitochondrial disease is a group of mitochondrial disorders where various genes that encode for the proteins and enzymes that function during metabolism in the mitochondria are mutated. For example, in some patients, the gene that instructs the cells on how to build a functional Complex I is mutated. This mutation causes a deficiency of functional Complex I enzymes in the mitochondria of these patient's cells, and so the electron transport chains are not able to function effectively during metabolism. This often has devastating effects on tissues and organs with high energy demands, such as the brain, the muscles and the heart. Lactic acidosis is a common symptom.

1. First, describe the mechanism by which a healthy electron transport chain functions to produce ATP.

2. Describe how the metabolic process would be altered if a person did not have adequate functional Complex I enzymes within their mitochondria.

3. Explain why lactic acidosis results in these patients. Explain why tissues with high energy demand are negatively affected.

Reference no: EM133289911

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